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Biomedical subjects

A Manning

Publications and source records attributed to A Manning.

At least 55 records · Page 3Linked to original sources
PubMed1987

The "shrunken" pancreas: a morphological variant of idiopathic chronic pancreatitis.

Six patients with idiopathic chronic pancreatitis are described in whom a pancreatogram showed an unusual morphology, being irregularly narrowed throughout. This "shrunken" appearance differs from the classic irregular dilatation usually seen in chronic pancreatitis. Two of the patients had inflammatory bowel disease, none had a history of alcoholism and only one had gallstones.

Adolescent↗
PubMed1983

Rooting and the development of male sexual behavior in two inbred mouse strains.

The sexual development of C57BL 6/J and SEC/IReJ male mice was studied during twice-weekly pairings with estrus females from 5 weeks of age. SEC were far slower to begin copulating than C57 and their responses to the female included a much higher frequency of rooting. Rooting, where the male's snout is pushed below the female's flank and jerked upwards, declines over tests as the full copulatory pattern develops. SEC also spent a higher proportion of their time in close contact with the female and groomed her more than C57. Both strains showed more rapid development of copulation if testing was delayed until 10 weeks of age, especially if they had exposure to female scent during this maturation period. The frequency of rooting and the speed of development are inversely related in these strains, but in segregating hybrid populations no such relationship is maintained. It is argued that the slowness of SEC's development cannot be ascribed to low sexual motivation. The significance of rooting remains obscure, but it seems possible that it may represent an aspect of exploratory behavior that is highly developed in SEC and some other strains.

Animals↗
PubMed1982

Vocabulary deficit and abstraction impairment in hospitalized alcoholics.

The use of a standard intelligence test for detecting cognitive impairment has been re-examined in a cohort of 506 hospitalized alcoholics. The value of Vocabulary scores as indicators of original intelligence was tested by formulating the hypothesis that Vocabulary scores would remain constant despite increasing degrees of alcohol-induced cerebral dysfunction. Subjects were assigned to non-dysfunctional, minimal and severe dysfunctional groups on the basis of psychometric testing and their Wechsler Vocabulary scores categorized as either 'abstract' 'concrete' or 'wrong'. Significant linear deficits in Vocabulary score and loss of abstract ability correlated with increasing dysfunction, irrespective of age but with greater frequency in females.

Adult↗
PubMed1976

Genotype and retention of the ejaculatory reflex in castrated male mice.

Genotype proves to be an important factor affecting the retention of sexual responsiveness following castration. Male F1 hybrids between C57BL/6 females and DBA/2 males (B6D2F1) show very prolonged retention. Experiment 1 used a diallelic design using C57BL/6, DBA/2 and BALB/c strains and showed that heterosis per se is not an adequate explanation of the superior retention of the B6D2F1 genotype. Experiment 2 showed that neonatal injections of 100 mug TP to B6D2F1 male mice did not result in better retention of the ejaculatory reflex after castration in adulthood. B6D2F1 males from both experiments who exhibited the ejaculatory reflex for many months after castration went through a 'difficult period' in the first 10 to 12 postcastration weeks. During this time, ejaculation latency increased fourfold, and then returned to the original level. On the other hand, the proportion of males reaching the ejaculatory threshold during this period first declined then increased.

Animals↗
PubMed1976

Effects of adrenalectomy on the sexual behaviour of castrated and intact BDF1 mice.

Two experiments investigate the effects of adrenalectomy on the capacity of male mice of the BDF1 genotype (C57B1/6Fa male X DBA/2 female) to retain sexual behaviour following castration. Adrenalectomy is without effect and it is suggested that androgens can play no part in the maintenance of sexual behaviour in these castrates.

Adrenalectomy↗
PubMed1976

Postcastration retention of sexual behaviour in the male BDF1 mouse: the role of experience.

Male BDF1 mice (the F1 progeny of a cross between C57BL/6 females with DBA/2 males) show a remarkable retention of sexual behaviour following castration. Two experiments were conducted to describe in detail the postcastration copulatory performance of the BDF1 male mouse and to determine to what extent such performance is influenced by experience prior to castration. Experiment I found that castration leads to significant increases in the number of mounts and intromissions needed to reach ejaculation, and to a significant increase in ejaculation latency. Experiment II found that although precastrational sexual experience is not essential for the performance of the ejaculatory reflex after castration, it does influence the frequency of its occurrence. Furthermore, type of post-weaning social experience influenced the display of ejaculatory behaviour by non-experienced castrates, as those with female social experience were superior to those with social experience with males or no social experience. The interactions of experience, hormones and genotype in the control of sexual behaviour in the BDF1 male are discussed.

Animals↗
PubMed1975

Courtship song and mating speed in hybrids between Drosophila melanogaster and Drosophila simulans.

Courtship song and mating speed of hybrids between Drosophila melanogaster and D. simulans were investigated. The courtship song of hybrid males is identical to that of D. simulans, suggesting that X chromosome determination, known from the cross between D. pseudoobscura and D. persimilis, is also possible here. Wingbeat frequency of hybrids is intermediate between that of the two parents, demonstrating that courtship song and wingbeat frequency are inherited independently of each other. In mating test, hybrid males cout and are accepted by D. simulans females more than hybrid females (presumably because their song is more "acceptable" to the former). D. melanogaster males readily, hybrids less readily, and D. simulans least.

Animals↗