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Biomedical subjects

A Manunta

Publications and source records attributed to A Manunta.

At least 37 records · Page 2Linked to original sources
PubMed1998

Flavonoids from genista ephedroides

Three new flavonoids (1-3) and 11 known compounds (genistein, isoprunetin, wighteone, laburnetin, alpinumisoflavone, genistin, genistein 8-C-glucoside, apigenin, isokaempferide, licoflavone C, and D-pinitol) were isolated from the aerial parts of Genista ephedroides. The structures of the new compounds were established as hydroxyalpinumisoflavone (1) [4', 5-dihydroxy-2"-methyl-2"-hydroxymethylpyrano(5",6":6,7)isoflavone], ephedroidin (2) [4',5, 7-trihydroxy-8-(2-hydroxy-3-methyl-3-butenyl)flavone], and genisteone (3) (7-O-glucosylwighteone) by means of spectroscopic methods.

Journal Article↗
PubMed1998

[Ureteral reimplantation on psoas bladder: long-term results].

OBJECTIVE: To evaluate indications and long-term results of ureteral reimplantation with psoas hitch bladder. MATERIALS AND METHODS: Between January 1985 and December 1997, we performed psoas-hitch ureteral reimplantation in 18 patients (13 females and 5 males). Mean age was 48 years old. All ureteral injuries involved a pelvic portion of the ureter. The indication was: ureteral injury during gynecological procedures in 5 cases, stricture following open uretero-lithotomy in 3 cases, avulsion of the ureter during ureteroscopy in 1 case, stricture following prior ureteral reimplantation in 3 cases, prostate cancer involving the distal ureter in 1 case, megaureter in 1 case, radiation therapy in 1 case, pelvic and ureteral endometriosis in 3 cases. Treatment consisted to adequate mobilization of the bladder, fixation of the posterolateral corner of the bladder to psoas and ureteral reimplantation with anti-reflux system. In all cases, psoas-hitch ureteral reimplantation has been performed because of an inability to perform end-to-end uretero-ureterostomy or direct uretero-neocystostomy. RESULTS: No complications were observed. At follow-up of 7 months to 12 years (mean 5.7 years) we noticed 13 success (72.4%), 4 improvements (22.2%) and one patient (5.4%) was lost at follow-up. No nephrectomy was done. CONCLUSION: Psoas-hitch bladder ureteral reimplantation is simple, effective and a first-line procedure for the replacement of the long defects of the lower ureter.

Adult↗
PubMed1997

Inositol 1,4,5-trisphosphate distribution in Lycopersicon esculentum Mill seedlings cultivated "in vitro" under different conditions.

Measurements of inositol 1,4,5-trisphosphate (Ins1,4,5-P3) in cotyledons, epicotyls and roots of tomato seedlings grown "in vitro" either in the light or in the dark indicated that higher concentrations of this signal-transducing molecule are contained in hypogeous vs. epigeous tissues. The same was observed in induced cotyledon explants grown in the light in the presence of growth regulators. Data concerning phosphatidylinositol metabolism in seedling roots are also reported. Taken together, our results may be helpful in understanding the role of the polyphosphoinositide signal system in plants.

Calcium Chloride↗
PubMed1995

Laparoscopic continent gastrostomy.

Surgical feeding gastrostomy is attended by a significant morbidity and mortality. The percutaneous endoscopic route is regarded as the best method, but it is not feasible in cases with pharyngoesophageal stenosis. We here describe a new method using laparoscopy. The technique is easy to perform. The patient retains continence, with the abdominal wall muscle acting as a sphincteric mechanism around the gastric tube.

Aged↗
PubMed1995

[Palliative treatment of cancer of the rectum using an urologic prostate resectoscope].

Palliative treatment for patients with rectal carcinoma concerns more than 10% of the 8000 cases diagnosed each year in France. Seventeen patients (median age: 83 years) underwent 27 endoscopic transanal resections using a urological resectoscope. The morbidity was 18.5% and there were no postoperative deaths. The median hospital stay for the procedure alone was 4 days. Local control was obtained in 13 (76%) patients with good palliation of obstruction, bleeding and tenesmus. The mean survival time was six months. This simple, minimally invasive and economic method should be part of palliative treatment for patients with rectal carcinoma together with laser destruction and external beam radiotherapy.

Adenocarcinoma↗
PubMed1994

Ultrastructural appearance of chondroblastoma.

The ultrastructural appearance of two chondroblastoma were examined by scanning and transmission electron microscopy. The polygonal basal cells, with a scanty pericellular matrix, show a poorly developed endoplasmic reticulum and many Golgi bodies. The highly differentiated chondroid cells are assembled in isogenous clusters and show intracytoplasmic inclusions of glycogen and lipids, numerous mitochondria and superficial secretion vesicles arising from a well developed rough endoplasmic reticulum. Clusters of crystals, in close contact with the matrix collagen fibres are found near to the tumour cells. These ultrastructural characteristics, together with the basal undifferentiated cells that proliferate and differentiate into cartilaginous tissue, distinguish this neoplasm from chondroma, mesenchymal chondrosarcoma and chondromyxoid fibroma and confirm its chondroid origin.

Adolescent↗
PubMed1993

Triterpenoid saponins from Bupleurum fruticosum.

Three triterpenoid saponins 1-3 of the oleanane series, containing one fucose and two glucose units, were isolated from the MeOH extract of the roots of Bupleurum fruticosum. Their structures were elucidated by means of fabms and a combination of homo- and heteronuclear 2D nmr techniques. Two of the three saponins are new.

Magnetic Resonance Spectroscopy↗
PubMed1993

Scanning electron microscopy study of articular cartilage in the evolution of hip arthritis.

The authors report the results of scanning electron microscopy examination of samples of articular surface taken from 15 arthritic femoral heads removed during hip replacement. The specimens were collected from areas of the femoral head where different degrees of degenerative changes were identified, and processed with the normal techniques for scanning electron microscopy. A definition was made of the mechanisms leading to articular cartilage wear, the most obvious sign of cartilage degeneration. The earlier stages were characterized by the appearance of clefts in the surface layer, which merged and formed scales that flaked off, giving rise to superficial abrasions. The evolution of the degenerative process led to a deepening of the clefts, reaching the intermediate and deep layers and creating further scales of cartilage tissue, oblique or perpendicular to the surface. The elimination of these formations causes more or less marked wear that can extend down to the subchondral bone (ulcers and ground surfaces). As well as information on the condition of the articular surfaces, scanning electron microscopy may also provide details on the morphology and structure of the chondrocytes and the fibrillar network in the sagittal sections, showing the regressive phenomena associated with arthritis.

Aged↗
PubMed1992

[The use of Sorbsan in the treatment of the donor site of skin transplantations].

Sorbsan is a new dressing composed of alginate fibers extracted from seaweed. It is claimed to have important hydrophilic, haemostatic and biocompatible qualities. Sorbsan was used in the treatment of the donor site of split skin grafts in 52 patients operated in this department from 1988 to 1990. The patients of this series required a skin graft for various reasons as detailed below: a) skin burns in 24 cases; 2) covering of a muscle flap used in the treatment of sacral pressure sores in 15 cases; c) 13 cases of loss of substance from other various causes. Healing time averaged 16.8-13.4 and 9.3 days respectively in the three groups reported above. In 85% of cases, healing was achieved in a period variable between one and two weeks and a half, varying in accordance with patient age and general conditions. The speed of healing, particularly where thin grafts were taken, allowed multiple split skin grafts to be taken from the same donor site, facilitating the treatment of extensive skin burns. The dressing can be removed with ease with only minimal discomfort to the patient. The incidence of side effects such as itching and scar hypertrophy or pigmentation is low. We haven't noticed any allergic reaction in this series. We found the use of this dressing satisfying in the treatment of donor sites of split skin grafts, particularly in terms of patient comfort and speed or healing.

Adolescent↗
PubMed1990

Morphological aspects of the synovial membrane and the femoral epiphyseal nucleus in anemia induced experimentally (note 1).

The authors describe the macroscopic and ultra-structural changes in the synovial membrane and the growth nucleus consequent to anemia induced experimentally. In the anatomical region studied an early and a late response to the transitory anoxia is observed. The former is represented by the accentuation of the macrophagic activity of the A synoviocytes and by pictures of trabecular fragmentation. The latter is represented by hyperplasia of the synovial membrane, a reduction in the thickness of the joint cartilage, and by early and patchy calcification of the epiphyseal disc.

Anemia↗
PubMed1990

[Perichondrial changes in the evolutionary course of traumatic lesions of the epiphysis in growth].

The authors conducted an experimental study aimed at defining the response of the perichondrium to traumatic stimuli. Thirty rabbits were used, subdivided into two groups: in the first group, the perichondrium was submitted to indirect trauma (fracture of the growth nucleus); in the other, to direct trauma (decortication of th perichondrium). We observed that the lesions constitute a stimulus for cellular proliferation with successive differentiation depending on various procedures. The mesenchymal cells of the deeper layer of the perichondrium reveal a tendency towards differentiation in a chondroblastic sense; the portion of these cells which face the metaphysis are generally differentiated to constitute typical cytotypes of the periosteum, giving way to membranous ossification phenomena. The more external layer reveals proliferation of its fibrovascular component. This experimental model allowed us to emphasise the proliferative tendency of so-called perichondrial cells (those of the deep layer). Thus, their role in providing the growth cartilage of new chondrocytes was confirmed, contributing to the transverse development of the metaphysis.

Animals↗
PubMed1989

[Acute colonic hemorrhage. Importance of a preoperative localization of the origin of bleeding in patients requiring emergency surgery].

Conservative management of distal gastro-intestinal bleeding is successful in most cases; 10% of patients hospitalised with this diagnosis will however undergo emergency surgery. Preoperative localisation of the bleeding site allows to perform a limited, segmental colectomy even in emergency. This has been shown to be associated with a lower operative mortality and morbidity when compared with subtotal colectomy. In this retrospective study we reviewed the notes of 134 patients admitted with lower gastro-intestinal bleeding. 22 of these required more than 4 units of blood transfusion and 12 underwent emergency surgery. Preoperative localisation of the source of bleeding was possible in 7 cases (58%); the remaining 5 underwent a subtotal colectomy. The operative mortality was 8%. The Authors emphasise the importance of an aggressive diagnostic work up in all cases of massive bleeding (i.e. more than 4 units of blood requirement in the first 24 hours following hospitalisation) in order to minimise the number of emergency subtotal colectomy.

Acute Disease↗
PubMed1989

[Parotidectomy as prophylaxis in malignant melanoma of the fronto-temporal and eyelid skin].

Three patients presented with parotid masses which revealed, on frozen section, to be metastatic lesions from malignant melanoma. Their medical history confirmed that the removal of cutaneous lesions of the frontal, temporal or eyelid skin had been performed presumedly without histologic examination. Disease staging was assessed as p-T0N1M0. Parotidectomy was performed in all cases without complications, and DTIC was given in one case. One patient died six months after surgery for metastatic disease, another one died disease-free, the third is available for the follow-up. The Authors recommend parotidectomy for prophylaxis in malignant melanoma more than 0.75 mm in thickness which is within a few centimeters of the parotid gland area. Lymphoscintigram might be useful occasionally.

Adult↗
PubMed1989

Papillary thyroid cancer with unusually aggressive behaviour. Case report.

A 22-year-old woman underwent thyroid lobectomy for papillary carcinoma (follicular variant). Local recurrences 4 and 7 months later, with vascular invasion and extrathyroid spread, required extensive surgery and radiotherapy. Ipsilateral lobectomy with near-total or total contralateral lobectomy is advocated for treatment of papillary thyroid cancer.

Adult↗