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Biomedical subjects

A Marinescu

Publications and source records attributed to A Marinescu.

At least 19 recordsLinked to original sources
PubMed1996

TCR binding differs for a bacterial superantigen (SEE) and a viral superantigen (Mtv-9).

Both superantigens (SAG) and many anti-TCR monoclonal antibodies (mAb) have specificity for the V beta region of the TCR encoded by TCRBV genes. For instance the bacterial SAG staphylococcal enterotoxin E (SEE), the retroviral SAG MTV-9 and the mAb OT145 each react with human T cells expressing BV6S7. This BV gene encodes two common alleles. We found that SEE and the mAb preferentially activate T cells expressing BV6S7*1 as opposed to BV6S7*2, but Mtv-9 activates T cells expressing either allele. Thus binding to the TCR differs between the two SAGs. A mutation in the TCR HVR-4 region of BV6S7*1 (G72E), where the two BV6S7 alleles differ, indicated that HVR-4 is a component of the binding site for SEE and for the mAb OT145. BV6S7*2 has a charged E72 which may result in electrostatic repulsion of SEE, as SEE contains a similarly acidic aspartic acid residue at a TCR interaction site (204D).

Alleles↗
PubMed1985

[Total "pharyngoplastia vera" with the colon in caustic pharyngo-laryngeal stenoses].

An original procedure for pharyngeal reconstruction with colon in pharyngolaryngeal stenosis due to chemical burns has been named "pharyngoplasty vera" by the authors, since the 3 walls of the pharynx are reconstituted by lining it with visceral material. This is in contradiction with previously used techniques in which the graft caps the pharyngostomy produced by resection of scar tissue (pharyngovisceral anastomosis). The procedure generally respects the principles of conventional cutaneous pharyngoplasty--similar approach, extirpation of scar tissue, epiglotto plasty, conservation of constrictor muscles and above all, solid attachment of visceral material to the latter, and finally suture of the colon at the base of tongue and closure of pharynx. The method was used in a patient who regained deglutition rapidly, but the insufficient glottic space did not allow reopening of the canal.

Adult↗
PubMedDate not supplied

Metastatic nonfunctioning parathyroid carcinoma: ultrastructural evidence of secretory granules and response to chemotherapy.

A 69-year-old woman was admitted to the hospital because of recurrent cervical nodules, a large anterior mediastinal mass, and malignant left pleural effusion. Light and electron microscopy of the resected cervical nodules and cytology of the pleural fluid showed findings consistent with parathyroid carcinoma. There was no evidence of hyperparathyroidism on clinical evaluation, multiple serum calcium and phosphorus determinations, skeletal survey, intravenous pyelogram, or radioimmunoassay of intact and carboxy-terminal parathyroid hormones in the serum. Electron microscopy revealed secretory granules in the cytoplasma of malignant cells. A dramatic and complete resolution of the mediastinal mass and pleural effusion occurred after 18 months of chemotherapy with "MACC" (methotrexate, adriamycin, cyclophosphamide and CCNU).

Aged↗
PubMedDate not supplied

[Clinical and therapeutic aspects of traumatic diaphragmatic hernia].

The authors present 5 cases of diaphragmatic hernia occuring after thoracoabdominal trauma (in one case the hernia was in the right hemidiaphragm, associated with partial hepato-thorax, the other four were in the left hemidiaphragm and were associated with intra-thoracic herniation of the stomach, transverse large bowel, large epiploon, loops of the small bowel and of the spleen). In three cases the lesion was treated by the thoracic route while in the other two the abdominal route was preferred. In one of the cases splenectomy and segmental transverse colectomy were performed by the transthoracophrenic approach. This was necessary because of the length of the pedicles, as well as of the risks entailed by an eventual attempt at re-positioning the viscera.

Adolescent↗
PubMedDate not supplied

Open clinical study of Clopixol-Acuphase (zuclopenthixol acetate) treatment followed by Clopixol Depot in acute psychoses with long-term course tendency.

The evolution of 28 patients displaying acute forms of psychoses (schizophrenia, mania, exacerbation of psychosis in chronic cases) was studied under the treatment with Acuphase Acetate continued with Clopixol Depot. In both therapies a tioxantenic neuroleptic is involved for the acute form of the illness (Acuphase) and for the maintenance treatment (Clopixol Depot). The assessment of the results was carried out on individual observation files using Global Rating Scale (G.R.S.), B.P.R.S. and paraclinical measurement to appreciate the biological tolerance. Favourable effects of treatment were evident in the first 4 days and in six cases even within the first 24 hours. The whole group of patients showed a significant decrease of morbidity evolving from a high severity to a medium and reduced one. The biological tolerance was very good, 6 to 12 months' care.

Acute Disease↗
PubMedDate not supplied

[Intraoperative cholangiography in acute cholecystitis].

Intraoperative control of the main bile duct is compulsory during surgeries for acute cholecystitis. The surgical cholangiography is essential within the investigation means and methods. Starting from their own experience and the literature data, the authors establish the indicators for intraoperative cholangiography in acute cholecystitis with reference to the specific methodology.

Acute Disease↗
PubMedDate not supplied

[Neglected peritonitis].

The analysis of 130 cases of neglected peritonitis shows the seriousness of the disease, that increases considerably with the time elapsed from the onset of the disease till the admission into the hospital. The peritonitis may have different causes, the most frequent ones being acute appendicitis and perforating ulcer. The related affections, when present, amplify, modify or, on the contrary make the symptoms confused. When a neglected peritonitis is suspected, the surgery is required, followed by an intensive treatment afterwards.

Acute Disease↗
PubMedDate not supplied

Cellular edema in nervous tissue.

The paper presents some mechanisms which determine or accompany cellular brain edema: intracellular and extracellular osmolality alteration, neuronal excitation, increased extracellular K+ concentration, anoxia, ischemia and hepatic encephalopathy.

Animals↗