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Biomedical subjects

A Markitziu

Publications and source records attributed to A Markitziu.

At least 37 records · Page 2Linked to original sources
PubMed1990

Dysgeusia, gustatory sweating, and crocodile tears syndrome induced by a cerebellopontine angle meningioma.

Facial nerve involvement in cerebellopontine angle tumors, both during their development and after excision, may be expressed in irreversible dysfunction of the parasympathetic pathways. The exact location of the lesion along the efferent nerve fibers can be established through evaluation of the functional level of those organs supplied by the cholinergic motor secretory components. This report deals with a female patient in whom peripheral facial palsy developed shortly after removal of a right cerebellopontine angle meningioma. She had slight facial asymmetry and deafness in the right ear and complained of prandial flush and sweating of the right malar area. Occult ipsilateral hyposalivation and hypolacrimation were diagnosed. In patients with seventh and ninth cranial nerve pathoses, evaluation of the end organs that are supplied by their associated autonomous nerve fibers is mandatory to prevent late ocular and oral sequelae.

Cerebellar Neoplasms↗
PubMed1990

Periodontal alterations in patients with pemphigus vulgaris taking steroids. A biannual assessment.

Periodontal health parameters and salivary cortisol were studied in 19 adult pemphigus vulgaris patients on chronic steroid therapy. The patient population was divided into non-medicated and medicated subjects at intake into the study. A significant difference between the 2 examinations, performed at an interval of 8.73 months +/- 4.35, was found in bleeding index (p less than 0.000 and p less than 0.04, respectively) and gingival recession (p less than 0.000 and p less than 0.009) in both groups. No changes occurred in alveolar bone height. Steroid therapy altered the bleeding index (R = 0.60 and R = 0.80) and gingival recession (R = 0.87 and 0.91) in a dose-related manner, and induced low salivary cortisol. The findings of this study would suggest suppression of the host inflammatory reaction, resulting in an alleged healthy clinical appearance of the periodontium.

Adolescent↗
PubMed1989

Oral soft tissue status in an elderly institutionalized population.

A total of 1,037 oral soft tissue lesions (3.98 lesions per patient) was found in 260 elderly people of American/European and of Asian/African extraction residing in a home for senior citizens in Jerusalem. There was a strong association between wearing of dentures or usage of bare mucosa for masticatory purposes and the presence of specific lesions at typical locations. A significant difference was found between the two ethnic groups with respect both to pattern of tooth loss and utilization of rehabilitative means. The distribution of the oral soft tissue lesions among the participants in the study seemed to be linked to their cultural background.

Aged↗
PubMed1988

Salivary gland function in patients on chronic lithium treatment.

Salivary gland function was studied in 14 manic-depressive patients treated with lithium carbonate (Li) for 4 to 120 months. Function level was evaluated by means of sialometry, dynamic salivary scintigraphy, and sialography. Daily Li dose, serum Li concentration, duration of Li therapy, and caries activity index were correlated with the salivary function parameters studied. Hyposalivation was noted in 71% of the patients, showing good correlation with the scintigraphic (r = 0.94) and sialographic (r = 0.87) results. Duration of Li therapy was poorly correlated with the degree of salivary gland dysfunction and with the caries activity index, whereas the correlation between duration of therapy and each of the three salivary function parameters was erratic. Because four of the patients exhibited normal salivation, we suggest that there are some additional factors (e.g., genetic or thyroid function level) that might be involved in salivary dysfunction connected with Li therapy.

Adult↗
PubMed1988

The clinical value of quantitative dynamic scintigraphy in salivary gland disorders.

Salivary gland scintigraphy with [99mTc]pertechnetate was performed in a group of 11 subjects without any known salivary pathology, and in a group of 12 xerostomic patients. Time-activity curves, normalized to background, were generated for each of the four major salivary glands in both groups, and averaged into single curves, representing the function of each gland. Comparing the two sets of curves (patients vs controls) demonstrates that utilizing our "normalization" approach enables one not only to determine whether one group of dynamic curves is significantly different from another, but to decide which of the glands are normal and which are malfunctioning. The sensitivity, specificity, accuracy and predictive values of this procedure are all above 0.90.

Adult↗
PubMed1988

The in vitro effect of lithium on growth and adherence of Streptococcus mutans 6715.

The in vitro effect of lithium (Li) on growth and adherence of Streptococcus mutans 6715 in the presence and absence of sucrose was examined by means of optical density and transmission electron microscopy. In the non-sucrose assay, bacterial growth was depressed and adherence was elevated between concentrations of 1.44-11.52 mmol/L Li. At 7.20 mmol/L Li extracellular material was present on the bacterial wall. Using 11.52-28.08 mmol/L Li resulted in a perfect negative correlation between the increasing concentrations of Li and bacterial growth and adherence (rs = -0.9 and rs = -1, respectively) in both assays. This paper addresses the dichotomy between the low and high Li concentrations regarding the two bacterial parameters studied, as well as their possibly related cariogenic and cariostatic clinical relevance.

Bacterial Adhesion↗
PubMed1988

Neutrophil function in patients with localized juvenile periodontitis and with rapidly progressive periodontitis.

PMN chemotactic function and oxydative metabolism were investigated in 13 patients with rapidly progressive periodontitis (RPP) and 9 patients with localized juvenile periodontitis (LJP) using a chemotaxis assay (CHA), luminol chemiluminescence (CL) and nitroblue-tetrazolium (NBT) tests. In the LJP patients there was a significantly lower CHA than in the RPP patients (less than 40%). Three out of the 13 RPP patients displayed a cell-dependent increase of CHA and in 3, the reduced CHA measured was serum-associated whilst among the 9 LJP patients, a cell-dependent defect of CHA was present in 5 patients, a serum-associated defect in one patient and a combined cell- and serum-associated defect was found in another patient. The average values of CL in the RPP patients were significantly lower (1309.3 +/- 814.2) than those measured in the LJP group (2208 +/- 826.9). In contrast, the mean NBT test values indicated a lower phagocytic function in the LJP patients than in the RPP ones suggesting also the presence of a serum-dependent factor in RPP and that of a combined cell- and serum-response in LJP. According to these results, the neutrophil dysfunction in RPP, as indicated by both the chemotaxis and the oxydative metabolism nature, was frequently associated with a serum factor.

Adolescent↗
PubMed1987

A ten-year follow-up study of alveolar bone loss influenced by two dissimilar Class II amalgam restorations.

Twenty paired approximal amalgam restorations (E) extended and unextended (NE) placed in twelve patients were followed up for 10 years. Measurements of the distance between the alveolar crest and (a) the apical margin of the filling (E and NE) or (b) the cementoenamel junction of the untreated control surface (C) were performed 1, 4 and 10 years following restoration placement. The bone loss associated with NE filling did not differ significantly from that of the control group and amounted to 0.4 mm in 10 years. The 10-year cumulative bone loss adjacent to the extended restoration (E) was 1.07 mm. Bone loss associated with the E restoration was significantly higher (P less than 0.001) than that of the NE and control groups at every period measured. During the first 4 years the yearly bone loss of the E group was 0.14 mm and then decreased to 0.08 mm during the last 6 years.

Alveolar Process↗
PubMed1986

The uptake of lithium ions by synthetic carbonated hydroxyapatite.

Carbonated hydroxyapatites in the presence of F- and Li+ were synthesized. Limited uptake (0.2-1.6 ppm) of Li+ by the apatites was observed, which was proportional to the initially added Li+ and the carbonate concentration of the samples. Fluoride has retarding effect on the Li+ uptake. Li+ causes a decrease in the solubility of carbonated hydroxyapatite.

Animals↗
PubMed1986

Thyroid papillary carcinoma presenting as jaw and parotid gland metastases.

A slowly progressing colloidal goiter of 20 years standing was excised in a 67-year old woman. Two years later, a metastatic tumor inducing facial swelling was diagnosed radiologically in the left parotid gland and left ascending mandibular ramus. The incisional biopsy confirmed papillary carcinoma of thyroid origin. The patient refused treatment. Six months later, she returned to the clinic and presented with advanced destructive changes of the involved structures. This rare case of unrestricted malignant growth may shed light upon the sequence and mode of metastatic invasion.

Aged↗
PubMed1985

Tooth wear, solubility and fluoride concentration of molar-tooth surfaces in rats maintained on simultaneous or separate intake of food and fluoridated drinking water.

Eighty rats, 20 days old, were fed a hard pellet diet and deionized or fluoridated (25 parts/10(6) F-) drinking water respectively for 40 days. Half were maintained on simultaneous food and water intake for 3 h, daily, and the remainder on separate intake of food for 3 h followed by drinking water for 3 h, daily. Scanning electron micrographs of the occlusal surface of right maxillary first molars were used for scoring wear. The mandibular and left maxillary molar surfaces were used for solubility and fluoride concentration determinations. Intake of food and water separately did not affect wear significantly, whereas solubility and fluoride concentration of the molar surfaces were significantly increased. Wear, solubility and fluoride of the molar surfaces respectively were highly significantly increased in the rats provided with fluoridated water. Increase in fluoride uptake is due in part at least to the increase in sites available for uptake due to tooth wear. Acid dissolution of worn tooth-surface enamel is greater than that of intact enamel.

Animals↗
PubMed1985

The effect of iron on in vitro decalcification of human tooth enamel.

The effect of iron chloride on an in vitro acid attack of human enamel was studied. Slices of teeth were covered with varnish except for a window left on one of the enamel surfaces for exposure. The iron salt was used as a supplement to acid gel, or as pretreatment of the enamel surfaces before exposure to the pure gel. Differences in light transmission of the experimental and control specimen from the radiographs taken before and after immersion in the decalcifying media were assessed quantitatively. The increase in radio-opacity of the enamel sections incubated in the iron-containing acid media was attributed to a lower degree of enamel decalcification.

Acids↗
PubMed1984

Major salivary glands in branchial arch syndromes.

In five patients with branchial arch syndromes the presence of the salivary glands was demonstrated. Clinical, sialographic, and scintigraphic examinations revealed morphologic defects and diminished function of the parotid glands. Hyperfunction of the submandibular glands was assumed in the three patients in whom scintigraphic studies were performed. The findings may be of diagnostic value in patients in whom the clinical signs of the syndrome have remained occult.

Adolescent↗
PubMed1984

A 4 year follow-up study of alveolar bone height influenced by two dissimilar Class II amalgam restorations.

Fifty-four paired, approximal amalgam fillings, extended (E) versus unextended (NE) were placed in forty-three patients and followed up to 4 years. Yearly measurements between the alveolar crest and (a) the apical margin of the fillings (E, NE), and (b) the cemento-enamel junction of the control group, were performed using bite-wing radiographs joined to a translucent grid magnified ten-fold. The rate of alveolar crest resorption was similar for the control (C) and the unextended filling (NE) and reached 0.45 mm after 4 years of follow-up. The resorption of the alveolar crest under the extended (E) filling was significantly higher and reached 0.80 mm after 4 years (P less than 0.001).

Adolescent↗