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Biomedical subjects

A Mashiah

Publications and source records attributed to A Mashiah.

At least 37 records · Page 2Linked to original sources
PubMed1984

Primary squamous cell carcinoma of the pilonidal area.

Two patients with primary squamous cell carcinoma of the pilonidal area are presented. No chronic infection or any other lesion predisposing to malignant transformation was present in either patient. Physicians and surgeons should be aware of the possibility of skin cancer appearing in this area in elderly patients. Biopsy of the lesion, leading to an early diagnosis, may prompt surgical treatment. Complete excision of the lesion is a prerequisite for cure.

Aged↗
PubMed1979

Changes in the coagulation of blood during resection of the abdominal aorta.

In 33 patients, a significant fall in the fibrinogen level occurred during an operation to replace the abdominal aorta by a bifurcated prosthesis. There was a similar, but less marked, fall in the fibrinogen level of ten patients having a femoropopliteal vein bypass. A concomitant drop in the plasma plasminogen value was also found. Results of specific laboratory tests for intravascular clotting and activation of fibrinolysis were negative. This suggests that fibrinogen may be removed by physical means. The fall in fibrinogen was so low in some patients that the routine administration of a conventional dosage of heparin could be dangerous.

Adult↗
PubMed1978

Drug therapy in intermittent claudication: an objective assessment of the effects of three drugs on patients with intermittent claudication.

It has been suggested that, by reducing the viscosity of blood, flow through capillaries is increased with consequent improvement in the symptoms of patients with peripheral vascular disease. We examined the effects of treatment with drugs purported to reduce blood viscosity to test the validity of this claim. Measurements of viscosity and the rate of blood flow to the leg were made in a group of patients before and after treatment with three different drugs--tetranicotinoylfructose (Bradilan), oxypentifylline (Trental) and cinnarizine (Stugeron). All patients had intermittent claudication in one leg and the distribution of arteriosclerosis was similar in each patient. After treatment there was little or no change in blood viscosity and no change in the rate of flow recorded in the symptomatic legs. We did not find any objective evidence to support the use of these drugs in patients with intermittent claudication.

Aged↗
PubMed1978

Aneurysms of the extracranial carotid arteries.

Aneurysms of the extracranial carotid arteries are unusual; they present difficulties in diagnosis and may cause death or cerebrovascular accidents in a majority of patients. This report describes three different types of aneurysm of the carotid arteries and their presentation and discusses their management.

Aged↗
PubMedDate not supplied

Extracorporeal removal of mercury by hemoperfusion through agarose-polymercaptal microsphere beads.

Uniform agarose-polymercaptal microsphere beads (APMMB) of 1.0-mm diameter were prepared by encapsulating thousands of polymercaptal microspheres of 0.8-micron average diameter within an agarose matrix. Those beads show a high avidity and affinity for mercury and readily remove mercury compounds bound to serum proteins. In vivo detoxification trials in dosed rabbits and dogs showed the effectiveness of the APMMB for removal of mercury compounds by hemoperfusion. The rate for mercury removal is enhanced by addition of cysteine. The biocompatibility of the APMMB, measured by the depletion of the formed elements and various soluble components of the blood, is also demonstrated.

Animals↗
PubMedDate not supplied

Extracorporeal removal of specific antibodies by hemoperfusion through the immunosorbent agarose-polyacrolein microsphere beads: removal of anti-bovine serum albumin in animals.

We describe the production of a unique immunosorbent system, agarose-polyacrolein microsphere beads (APAMB) for removal of a specific antibody, anti BSA, and its efficacy in animal trials. This is a model system for hemoperfusive removal of specific antibodies or antigens directly from whole blood. The agarose beads (1.0 mm mean diameter) contain thousands of microspheres of 0.2 micron mean diameter. The microspheres which contain the ligand are encapsulated within an agarose matrix to confer physical strength, biocompatibility, spacial configuration, and porosity allowing rapid entry of plasma for reaction. Any antigen may be linked covalently to spacers on the polyacrolein microspheres to remove a specific antibody, or vice versa. Thus the APAMB remove specific molecules in contrast to the charcoal or ion exchange resins currently in use. Removal of antibody is efficient and rapid, therefore, short hemoperfusive times may be used. The beads are biocompatible; there are negligible decreases in RBC, WBC and platelets. Electrolytes and other soluble components also are minimally affected. Therapy, at the least palliative, of autoimmune disorders i.e., multiple myeloma, macroglobinemia, autohemolytic anemias, idiopathic thrombocytopenia, myasthenia gravis, rheumatoid arthritis, thyroiditis, glomerulonephritis, etc, is potentially available with this or its further improved versions.

Acrolein↗
PubMedDate not supplied

Repair of internal carotid aneurysm under local anaesthesia. Case report.

Aneurysms of the extracranial carotid arteries are unusual events but cause death or a cerebrovascular accident in the majority of cases (50-70%). This report describes a true internal carotid artery aneurysm that developed within six weeks. The aneurysm was resected and the artery repaired by the use of a graft from the internal jugular vein. Carotid cross-clamping time was 93 minutes. The operation was performed under local anaesthesia, with continuous clinical monitoring of the ipsilateral cerebral hemisphere function.

Anastomosis, Surgical↗
PubMedDate not supplied

Ultrasound screening for abdominal aortic aneurysms in patients with atherosclerotic peripheral vascular disease.

The rapidly rising incidence of abdominal aortic aneurysm (AAA) and the grave prognosis in cases of rupture call for early detection and operative intervention. However, there is as yet no consensus on which groups in the population should be selected for screening. Some Authors have suggested the screening of populations at risk by virtue of their age, sex and/or the presence of arterial hypertension, and report the incidence of AAA in these populations as 5.3%, 3.4% and 0.25%, respectively. In this study we screened a group of patients with atherosclerotic peripheral vascular disease. Within this group the incidence of aneurysms was found to be 5.9%, which is at least twice the estimated incidence in the general population. Three of the six patients discovered, successfully underwent surgery. We conclude that screening of this specific population group is considerably more cost-effective than universal screening.

Aged↗