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Biomedical subjects

A Masse

Publications and source records attributed to A Masse.

At least 19 recordsLinked to original sources
PubMed1992

Correlation of endogenous acetyl-ser-asp-lys-pro plasma levels in mice and the kinetics of pluripotent hemopoietic stem cells entry into the cycle after cytosine arabinoside treatment: fundamental and clinical aspects.

A decrease of endogenous acetyl-ser-asp-lys-pro (AcSDKP) levels in murine plasma was observed after Ara-C treatment. This decrease preceded the entry of pluripotent hemopoietic stem cells (CFU-S) into the cell cycle. This suggests a correlation between CFU-S kinetics and levels of endogenous AcSDKP. The subsequent increase of AcSDKP levels seem to indicate a feedback mechanism which should permit the reestablishment of homeostasis in the stem cells. Therefore, the expulsion of the physiological brake may be the response to a signal (stimulatory factors) to start dividing and the retention of the physiological brake may the mechanism for a return to normal values of cell proliferation.

Animals↗
PubMed1990

[History and epidemiology of congenital hip dislocation in Brittany].

Brittany is a region of France with a high rate of congenital dislocations of the hip (CDH). This was shown by Le Damany, who, in 1912, did a systematic screening of newborns and compared the number of CDH in Paris and Rennes. In Paris, there was 0.8% and in Rennes 3.6% CDH. This frequency is not generalized in Brittany, however; and Setter, who did a large survey in Finistère in 1961 and 1962, showed that the epicenter was the canton of Pont l'Abbé, also called "pays Bigouden". However, this disease did not occur in this region of France in earlier times. In 1795, Cambry, according to the "Convention de la Jeune République", travelled in Finistère from village to village and did not notice any limping women. This was a very serious and precise study, and we may conclude that there was no CDH at that time; the disease occurred later in "pays Bigouden". From these basic facts, certain hypotheses are considered. From the point of view of genetics, a mutation apparently occurred in the 19th century, but there is no reliable genetic study. Autosomic heredity with incomplete penetrance, with variable penetrance according to sex may be considered: it includes a multifactorial origin of the disease involving genetics, environmental, biochemical and ethnic factors, including local customs and traditions.

Adult↗
PubMed1989

[Syndrome of compression of the external saphenous nerve (or the sural nerve)].

The authors describe a new canal syndrome, which they call the "superficial sural aponeurosis canal syndrome" or "sural nerve tunnel syndrome". Mostly seen in sportsmen, it was observed in this case in the context of a myositis ossificans circumscripta of the tendo-muscular junction of the heel. The clinical signs are caused by compression of the sural nerve where it passes through a nonextensible tunnel formed by the fold of the posterior sural aponeurosis. This is distinguished from a loge syndrome; the most typical clinical sign is increased pain in the territory of the sural nerve during plantar flexion of the ankle; in this position reduced sensory conduction velocity is measured. The treatment consists in a section of the fibro-aponeurotic arch.

Female↗
PubMed1988

[Comparative efficacy of antibiotic prophylaxis using cefoxitin in one or in three doses in cesarean section].

To compare the effectiveness of three doses and of a single dose of cefoxitin, a second-generation cephalosporin, in preventing infection after nonelective cesarean section, we carried out a prospective study in 255 women who underwent the procedure between March 1983 and February 1985. The rate of postoperative infection was 7% in the group that received three doses and 8% in the one-dose group. The sensitivity and specificity of perioperative cultures were low. The rate of asymptomatic bacteriuria was high, at 20%, but few symptomatic urinary tract infections were found. Routine antibiotic prophylaxis with a single dose is suggested for all nonelective cesarean sections.

Adult↗
PubMed1987

[Entrapment syndrome of the superficial posterior sural aponeurosis].

The development of a large circumscribed area of myositis ossificans at the junction of the aponeurosis of the tendo Achilles and the calf muscles may cause compression of the lateral saphenous nerve beneath the tight aponeurotic arch. The condition is usually encountered in athletes. Plantar flexion of the ankle will produce pain and diminution of sensation in the area served by the nerve. Treatment is by section of the tight band.

Achilles Tendon↗
PubMed1987

[Initial degeneration of the articular cartilage in the rat].

The authors have investigated the process of degeneration of articular cartilage in its early stages using an experimental model which has made it possible to show, for the first time, the effects of a mechanical parameter other than excessive pressure--that is excessive friction. The two healthy hips in twenty anaesthetised young rats were used for the study. One hip was kept immobile and served as a control. The other was subjected to physiological movements of flexion and extension continuously and without rest for periods varying from twelve hours to seven days. The articular cartilage of the two femoral heads was examined by light microscopy, transmission electron microscopy and scanning electron microscopy. A new fact was demonstrated. Cartilage wear is also associated with the simple movement of two joint surfaces over one another without any muscle contraction being involved. In the genesis of cartilage wear, excessive friction alone seems to be as important as excessive pressure.

Aging↗
PubMed1985

[Medial and lateral discoid menisci in the same knee. Apropos of a case].

To our knowledge, the case of association of discoid lateral and medial menisci in the same knee has not yet been reported. There are several factors which may contribute in the development of discoid meniscus: usually congenital, the types described by SMILLIE and WRISBERG must be distinguished and have not the same prognosis; thus, the discoid meniscus only acquired after birth seems rare.

Adolescent↗
PubMed1985

[Passage of commercial heparin and a low molecular weight fragment of heparin, CY 222, across the placenta of pregnant rabbits].

Because of a further clinical use of low-molecular weight heparin fraction in prevention or treatment of venous thrombo-embolism, it was necessary to establish whether they cross the placenta. The studies were performed in pregnant rabbits. High doses of commercial unfractionated heparin (1 000 and 1 600 anti-Xa units per kg of body-weight) and high doses of a low molecular weight heparin fraction (1 000; 8 000 and 16 000 anti-Xa units per kg of body weight) were injected to animals at the end of gestation (term: 30 days). The placenta crossing was studied by drawing blood samples from the mother and foetus for assays of heparin blood level. There is no detectable levels of heparin in the foetus at any time after injection of commercial heparin at the dose of 1 000 anti-Xa units per kg; meanwhile heparin blood level is very low at the dose of 16 000 anti-Xa units/kg. The low molecular weight heparin fraction do not cross the placenta at the dose of 1 000 anti-Xa units/kg. However for higher doses (8 000 and 16 000 anti-Xa/kg) this heparin fraction gives a foetal heparin blood level upper than the one given by commercial heparin.

Animals↗
PubMed1984

Anatomical relationship between the medial head of the gastrocnemius and the occurrence of a dystrophic bony lacuna.

A bony lesion with identical radiological features was seen in the medial part of the distal femoral metaphysis in five patients who practised cross-country motorcycling. These findings suggested that the cause of the lesions was of muscular origin. The nature and physiopathogenesis of the lesions were studied by roentgenography, computerized tomography and analysis of anatomical specimens. The results of these procedures were compared to observations made peroperatively. The lesion was identified as a specific, dystrophic bony lacuna resulting from the action of the medial head of the gastrocnemius (caput mediale m. gastrocnemii). In certain conditions this powerful biarticular muscle induces multiple microtrauma via traction on the structures of its tendinous insertion, especially the underlying bone, thus leading to bony avulsion. It is shown in this study that the bone-tendon-muscle complex forms a veritable biomechanical unit.

Adult↗
PubMed1984

[Duodenal absorption of a low molecular weight heparin in rabbits].

Commercial heparin cannot practically cross the intestinal barrier. Meanwhile, because of the theoretical interest in oral heparin therapeutics, we applied our studies to a low molecular weight heparin fraction (3 000 to 4 000 D). This fraction was directly injected into anaesthetized rabbit duodenum. For an equal anticoagulant activity (expressed in international units), commercial heparin is not absorbed whereas the low molecular weight fraction mainly induces an early plasmatic anti-Xa activity which remains over the fifth hour.

Animals↗