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A Massougbodji

Publications and source records attributed to A Massougbodji.

At least 19 recordsLinked to original sources
PubMed2006

[The re-emergence of the human African trypanosomiasis in Kerou, Benin].

Located in the northern part of Bénin, the district of Kérou is an historical HTA focus of the 60s formerly called the "Atacora focus". This survey was conducted in 2001 to determine the prevalence of HAT in Kérou. The methodology consisted in a cross-sectional survey based on random sampling with two levels of stratification. 3367 persons were included (i=5%). After a screening based on CATT test with total blood test, the examination of trypanosomae was performed with QBC on the subjects that have some persistent antibodies above serum dilution at 1/4, followed by lumbar puncture. For 3367 surveyed subjects, the CATT seroprevalence test with total blood sample is 4.2% and it is 2.4% with serum dilution at 1/8. The research of trypanosomae with QBC is positive in 48 patients and the prevalence is 1.4%. The community survey conducted among 106 positive persons with CATT test serum at 1/4 dilution has revealed that 71 (67%) persons have never left the area since their birth. The HAT is actually emerging in Atacora district in the north of Bénin, especially in Kérou.

Adult↗
PubMed2005

Prevalence and risk-factors for Helicobacter pylori infection in urban and rural Beninese populations.

In total, 446 healthy individuals (240 in urban and 206 in rural environments, respectively) were selected from 96 households, based on cluster sampling of residential location. Demographic, sociological and environmental data were collected by face-to-face interviews using a standard questionnaire. Infection with Helicobacter pylori was assessed by detection of anti-H. pylori IgG serum antibodies. The prevalence of H. pylori antibodies was 75.4% in the urban population and 72.3% in rural (village) residents (p 0.459). No association was found between infection and age, gender, education level, size of household, economic activity or source of drinking water. The infection rate was higher in children whose parents were both infected, and also in children whose mother was infected (p < 0.001). By logistic regression analysis, the density of occupation of sleeping accommodation (more than three persons sharing a room; 95% odds ratio (OR) = 9.82 (4.13-23.31), p < 0.001), and the mother's status within the household (95% OR = 3.85 (1.53-9.67), p 0.003), were independent predictors for H. pylori infection. The 74% seroprevalence of H. pylori infection found in healthy Beninese individuals is similar to that reported previously from other parts of sub-Saharan Africa. Family contact with infected persons and crowded living conditions were associated with increased risk of infection. These findings are consistent with intra-familial H. pylori transmission and suggest that improvement of living conditions should be protective against infection.

Adolescent↗
PubMed2005

Round table of November 20th, 2004: recommendations for improving the management of envenomations.

The round table underlines the necessity to follow the epidemiological and clinical surveys in order to precise the incidence and severity of snakebites and inform the health authorities that could thus arrange to take in charge envenomation accidents. Simple therapeutic protocols adapted to epidemiological and clinical data will be elaborated according to each level of health pyramid. They will be included in the health staff training and integrate traditional practitioners whose role must be clearly defined. An experimental and clinical validation must confirm its appropriateness with countries and victims needs. Some microeconomic surveys are necessary to identify adapted funding and thus improve their accessibility

Africa↗
PubMed2004

[Monitoring and assessment indicators in 2001 of "Roll Back Malaria" initiative in Benin].

Within the context of WHO/CDS/RBM/2000, a survey was conducted in 2001 by the National Malaria Control Program of Benin. Following a well-thought-out choice, the survey took place simultaneously in health areas corresponding to epidemiological regions. Morbidity due to malaria is very high among children under five years admitted in external clinic (44.3% of cases) and (46.5%) for hospitalization. The crude rate of mortality is 129%. The use of non-impregnated bednet is usually met in three health areas, where 47.4% of the household have at least one non-impregnated bednet versus 5.4% of household with impregnated bednets. Percentage of pregnant women sleeping under an impregnated bednet and following chemoprophylaxis is respectively 43.3% and 3.8%. Results obtained at the end of this database survey in 2001 have facilitated the definition of indicators of the process, results and impact which remain very useful for the implementation of the monitoring and assessment system of "Roll Back Malaria" in Benin.

Adolescent↗
PubMed2003

[Limits and weaknesses of intermittent treatment in malaria prevention].

WHO proposal of a new strategy for the control of malaria, intermittent treatment using sulfadoxine-pyrimethamine, encounters various conceptual and logistic problems. First, the treatment is dedicated only to a very small part of the population which is not representative of the population at risk. Secondly, it largely underestimates the risks of this type of drugs. At last, the difficulties of its management should lead to hamper this strategy. It would be preferable to study the real causes of the current strategy failure and to take it into account for a new strategy.

Antimalarials↗
PubMed2002

[Geoclimatology and severity of snake bite envenomations in Benin].

Envenomations following snakebite are common in Benin where they constitute, particularly in certain areas, a significant problem for the local populations and health workers. The present epidemiological study describes the snakebite envenomations which occurred in 18 medical centres of the country (6 departmental hospitals and 12 provincial hospitals). The studied variables were: prevalence, length of hospitalisation, major complications, quality of therapeutic management and development of the disease according to area. The study covered a period from April 2000 to March 2001. 486 cases of snakebite necessitating hospitalisation were notified including 413 (85%) in the two northern departments: Atacora and Borgou. Males were largely predominant (90%) and patients under 40 years were the most numerous (82%). The dry season seemed a period of higher risk (75% of the cases). The delay between the bite and admission to hospital, studied for 120 patients in the area of Atacora (North-West Benin), was relatively long: the average was 4 days, with extremes ranging from 10 hours to 21 days. This delay explained the severity of the complications diagnosed. They can be listed according to decreasing frequency: shock, coagulopathy, acute renal failure, respiratory distress. Less than 20% of the patients could benefit from antivenom. Management in emergency care units was impossible in most cases, none of the medical centres (except in Porto-Novo, the capital) having an intensive care unit with artificial ventilation available. Average mortality was 22%. Poisonous snakebites remain serious in Benin, mainly in the northern part of the Country. Access to health care and the quality of the management must be improved. This will require significant efforts from health workers, medical authorities as well as the local population. It is urgent to plan a national therapeutic consensus to reduce the high mortality due to snakebites.

Acute Kidney Injury↗
PubMed2002

[Epidemiological data on snake bite cases reported in Benin from 1994 to 2000].

Snake bites constitute a frequent occupational injury, mainly occuRring during agricultural activities in Benin as in the majority of tropical countries. The present study was performed within the scope of a periodic epidemiological analysis of occupational injuries over the past 15 years. It is a retrospective study based on the snake bites reported by the Ministry of Public Health from 1994 to 2000. The data collected through the medical centre registers showed that, with a total of 30,273 cases declared during these 7 years, snakebites represent less than 1% of the whole causes of admission. Although the prevalence was weak, the lethality was very high (15%). Envenomations involved more deaths than malaria and acute respiratory infections together. One third of cases occurred in adults and teenagers. Lethality in infants was not negligible. The two departments of northern Benin accounted for 314 of the envenomations. Lethality does not appear to be decreasing. The routine management of cases should be improved by appropriate training for health care workers and the introduction of a therapeutic strategy at every level of the medical system.

Adolescent↗
PubMed2002

Round table and synthesis of the meeting.

Our knowledge of the epidemiology of scorpion stings and snakebites remains fragmentary but sufficient, nevertheless, to be able to confirm that envenomations constitute a real public health problem throughout Africa. In order for the health authorities to be able to improve management of this problem, data collection must be enhanced. The objective should be to determine what kinds of intervention are necessary (quantity of antivenom serum and drugs, in particular) and where they should be applied. Specialists must come to a rapid consensus for a simple therapeutic protocol to be used in peripheral health centres where means are often scarce. Training for health personnel is also insufficient. Appropriate courses must be organised for medical doctors and nurses within both their basic and on-going training. These courses must necessarily involve health personnel from rural zones must affected by envenomations. The availability of antivenom serum--the only specific, efficacious drug--must be improved as soon as possible. If quantitative and geographic needs can be determined by epidemiological studies, then distribution must be developed by original means (grouping orders at national level, direct orders) and diversified financial support (purchase on the open market, local authority grants, community participation). The symposium attendees agreed to meet again within two years' time to evaluate progress in the area.

Africa↗
PubMed2000

Molecular characterisation of Plasmodium reichenowi apical membrane antigen-1 (AMA-1), comparison with P. falciparum AMA-1, and antibody-mediated inhibition of red cell invasion.

Apical membrane antigen 1 is a candidate vaccine component for malaria. It is encoded by a single copy gene and has been characterised in a number of malaria species as either an 83-kDa de novo product (Plasmodium falciparum; Pf AMA-1) or a 66-kDa product (all other species). All members of the AMA-1 family are expressed during merozoite formation in maturing schizonts and are initially routed to the rhoptries. Processed forms may subsequently be associated with the merozoite surface. Because of the unique occurrence of the 83-kDa form in P. falciparum we were interested to determine whether the phylogenetically closely related chimpanzee malaria Plasmodium reichenowi shared characteristics with Pf AMA-1. Here we show that the molecular structure, the localisation and processing are similar to that of Pf AMA-1 and that in vitro growth inhibitory mAbs reactive with Pf AMA-1 also inhibit P. reichenowi growth in an in vitro assay. Polymorphism in the 83-kDa AMA-1 family was analysed through comparison of Pr ama-1 with Pf ama-1 alleles, which showed the most significant evidence for selection maintaining polymorphism in Domains I-III of AMA-1 in P. falciparum. The most substantial divergence between Pr AMA-1 and Pf AMA-1 sequences was in the N-terminal region unique to the 83-kDa form of AMA-1. It was confirmed that the specific Pr ama-1-type allele was not present among P. falciparum parasites in an African population, and an allele coding for lysine at amino acid 187 was uniquely associated with field isolates in this population.

Adolescent↗
PubMed2000

[Granulomatous peritonitis from ascariasis: apropos of 1 case in a Benin child].

We report a case of granulomatous peritonitis in a child, due to Ascaris lumbricoïdes eggs. A 6 year-old child was admitted to the emergency ward with acute abdomen pain. Upon performing a laparotomy, severe adhesive inflammation and adenopathies were found and abdominal tuberculosis was diagnosed. Specific treatment was administered. Later, the acurage diagnosis of Ascaris ova peritonitis was made by histopathological examination of tissue removed during the operation. The pathogenesis is briefly discussed.

Abdominal Pain↗
PubMed1999

[Epidemiological observations on the first case of human paragonimiasis and potential intermediate hosts of Paragonimus sp. in Benin].

Parasitological investigations were carried out for four months in 1998 in two Beninese centres of pneumo-phtisiology (Akpakpa, at Cotonou, and Akron, at Porto-Novo) to detect the patients harbouring eggs of Paragonimus sp. amongst the persons consulting for tuberculosis and showing a broncho-pneumopathy without mycobacteria. Eggs of Paragonimus sp. were detected in the sputum of a single patient out of 369 persons examined (prevalence, 0.2%). This patient had eaten crabs in the months preceding the date of diagnosis. A treatment using praziquantel has improved clinical symptomatology and biological signs found in this patient. These studies have been completed by visiting markets located in the coastal plain of Benin to identify the crabs that were sold and to find metacercariae of Paragonimus sp. Negative results were obtained when 126 Cardisoma armatum ("hole crab") were dissected. In contrast, the dissection of 176 Callinectes marginatus ("swimming crab") was successful, with 5% of crabs harbouring metacercariae of probably Paragonimus sp. Further studies are necessary to confirm these first results and to determine the global prevalence of Paragonimus infection in these definitive and intermediary hosts.

Aged↗
PubMed1998

Lymphatic filariasis in a hyperendemic region: a ten-year, follow-up panel survey.

The present study is a long-term panel survey of a population living in a previously identified Wuchereria bancrofti-endemic area of Benin. Unexpectedly, a marked decrease in the prevalence of microfilaremia (from 9.4% to 0.48%; P < 0.001) occurred over a 10-year period in the absence of chemotherapy or vector control measures. The percentage of patients with chronic pathology remained stable during the study period. The decrease in the prevalence of parasitemia could not be explained by environmental or sociologic changes in the region, or by differences between the two study populations. These data suggest that the epidemiology of lymphatic filariasis in an endemic region may change independently of recognized modulating factors.

Adolescent↗