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Biomedical subjects

A Mathai

Publications and source records attributed to A Mathai.

45 records · Page 3Linked to original sources
PubMed1982

The role of hyaluronidase in experimental cryptococcal infections.

Cryptococcal infection established in adult male albino rats under experimental conditions produced minimal tissue response to the infection, probably owing to the presence of cryptococcal capsular polysaccharide. Following hyaluronidase administration in the active phases of experimental cryptococcal infection, we have observed characteristic histiocytic granulomatous transformation in cerebral as well as extracerebral lesions. It is postulated that hyaluronidase depolymerizes the capsular mucopolysaccharide of Cryptococcus neoformans and causes its lysis. As a consequence, cryptococcal yeasts that are devoid of their protective capsule and exposed to the host phagocytic system evoke a granulomatous response. Possible application of hyaluronidase as an adjuvant in the therapy of cryptococcal infections needs to be assessed.

Animals↗
PubMedDate not supplied

Diagnostic utility of polymerase chain reaction and immunohistochemical techniques for the laboratory diagnosis of intracranial tuberculoma.

In an attempt to establish a tuberculous etiology, polymerase chain reaction (PCR) and immunohistochemical (IHC) methods were undertaken in formalin-fixed paraffin sections of ten surgical specimens of intracranial tuberculoma. The control group included an equal number of intracranial fungal granuloma. Both PCR and IHC methods did not yield false-positive results in fungal granuloma. PCR was found to be less sensitive (60%) than IHC method (80%) in this study. IHC method definitely possesses several operational advantages over PCR and is more suited to laboratories in developing countries for establishing a tuberculous etiology particularly in those patients in whom the conventional bacteriological methods did not confirm the diagnosis of tuberculoma.

Adolescent↗