[Rhabdomyolysis secondary to moderate physical exercise].
Explore the source record for details and available documents.
Adult↗
Biomedical subjects
A Matilla
Publications and source records attributed to A Matilla.
cis-dichloro-palladium(II) complexes with diaminosuccinic acid and its diethyl ester: synthesis, molecular structure, and preliminary DNA-binding and antitumor studies.
The reactions of K2PdCl4 with meso-diaminosuccinic acid (H2dasa) in 0.1 M HCl or its diethyl ester dihydrochloride Et2dasa.2HCl in neutralized aqueous solution yield cis-[Pd(H2dasa)Cl2](I) and cis-[Pd(Et2dasa)Cl2](II), respectively. These products were characterized by elemental analysis, IR spectroscopy, and TG-DTA thermal analysis. The crystal of II is monoclinic, space group C2/c (a = 14.292(5), b = 14.636(5), c = 13.435(5) A, beta = 98.08(2) degrees, Z = 8, R = 0.041 and wR = 0.06). The Pd(II) atom exhibits a roughly square planar coordination with two Pd-N bonds (Et2dasa) (2.014(2) and 2.049(7) A) and two cis-imposed Pd-Cl bonds (2.294(2) and 2.303(2) A). Compound I reacts with 2,2'-bipyridine in neutral aqueous solution to give [Pd(2,2'-bipy)(dasa)].3H2O(III) in a process of cis-chloride substitution by 2,2'-bipy as a model N-heterocyclic chelating entity. The molecular and crystal structure of III is also reported. It was observed that both cis-dichloro-Pd(II) complexes having Pd(H2dasa) (acidic) and Pd-(Et2dasa)(esterified) chelate entities induce conformational changes in the covalent closed circular (ccc) form of pUC8 plasmid. Both compounds were assayed for antitumor activity in vitro against MDA-MB 468 and HL-60 human cancer cell lines. The results show that compounds I and II have values of ID50 lower than those of K2PdCl4, and also lower than those of diaminoacid ligands (meso-diaminosuccinic acid and meso-diaminosuccinate diethyl ester). Thus it is likely that the imposed cis-coordination of the chelating H2dasa or Et2dasa to the Pd(II) center increases the biological activity of these palladium(II) complexes.
Amino Acids, Diamino↗
Prognostic factors in bladder cancer. A pathologic, immunohistochemical, and DNA flow-cytometric study.
Pathologic grade and stage, immunohistochemical analysis of eight cell and tumor markers, and DNA ploidy were studied in 36 cases of bladder cancer to determine the features of value in assessment of patients' survival. Tumors of high grade and advanced stage correlated with DNA aneuploidy, whereas low grade and early stage correlated with DNA diploidy when simultaneously evaluated with survival. In addition, blood group isoantigen A correlated with DNA ploidy in deceased patients, whereas blood group isoantigen H and oncogene-related protein p21 correlated with DNA ploidy in surviving patients. Despite the relatively small number of cases studied, these results suggest that pathologic grade and stage and immunohistochemical analysis of blood group isoantigens A and H and oncogene-related protein p21 hold additional value in the prediction of bladder cancer survival when evaluated simultaneously with DNA ploidy.
ABO Blood-Group System↗
t(3;14)(q26;q11) associated with megakaryoblastic transformation of chronic myeloid leukemia.
Explore the source record for details and available documents.
Adult↗
Multiple endocrine neoplasia type 2b in twins.
The syndrome of multiple endocrine neoplasia (MEN or MEA) type 2b is characterized by the association of medullary carcinoma of the thyroid, phaeochromocytoma, ganglioneuromatosis and Marfan-like features. Though this disorder usually shows a familial distribution, it may also appear spontaneously as the result of a genetic mutation. This paper describes the second case of MEA type 2 in twins, and appears to be the first description in twins of the association of medullary carcinoma of the thyroid, Marfan-like features and multiple neuromas.
Adolescent↗
Extragenital endometrioid cystadenofibroma.
We present a case of extragenital endometrioid cystadenofibroma, whose rare pelvic localization is the motive for its publication, as no similar case had been described previously. Its possible histogenesis from a pelvic mesothelium, as well as the differential diagnosis from pelvic endometriosis is discussed.
Adenofibroma↗
Oat cell carcinoma of the oesophagus. Case description and review of the literature.
The small oat cell type of carcinoma is only rarely seen in extrapulmonary sites. To date, nineteen cases have been described in the oesophagus, almost all by Japanese authors. In this report we review the relevant literature and add one more case of pure type to the total. The histopathological, histochemical and ultrastructural findings and the similarity of this tumour to the oat cell bronchial carcinoma, lead one to propose that it originates in the cells of the APUD series, which have been demonstrated in the normal oesophageal epithelium. Thus is represents on endocrine carcinoma of the oesophagus.
APUD Cells↗
Adrenal myelolipoma simulating a retroperitoneal malignant neoplasm.
We describe a case of a large myelolipoma (15 by 12 cm. maximum diameter) that was removed surgically and resembled clinically and semeiologically a malignant retroperitoneal tumor. The patient also had chronic pancreatitis and cholelithiasis. Experimental findings, as well as the frequent association of myelolipomas (usually small) with several chronic diseases, suggests that the adrenal myelolipoma is not a true neoplasm but, rather, a choristoma or, perhaps even more likely, a hyperplastic and/or metaplastic lesion.
Adrenal Gland Neoplasms↗
'Benign' fibrous histiocytoma of the trachea.
Fibro-histiocytic neoplasms are uncommon in the respiratory tract. This paper presents a clinical and histological description of a case of fibrous histiocytoma at the level of the third tracheal ring. This cases shares some features with the four cases previously described, viz., the growth occurs mainly in young adults; recurrences are common; and all have shown similar benign histological patterns. Ultrastructural investigations confirmed the fibro-histiocytic nature of the neoplasm.
Adolescent↗
[Current considerations on pathology in Ewing's sarcoma].
The authors make a review of the correlation between the clinical and pathological data in Ewing's sarcoma. The morphological lesions are generally wider than those given by the radiographic record. The microscopic picture is the same for both osseous and extraosseous cases. The different cell types of Ewing's sarcoma are indicated, all of them giving rise to a similar clinical picture. The histogenesis of the disease is still discussed, the most favored hypothesis being that it originates in the non-differentiated mesenchyma of the primitive bone marrow.
Bone Neoplasms↗
[Symptomatic renal angiomyolipoma associated with tuberous sclerosis].
A kidney angiomyolipoma associated with tuberous sclerosis is described. This rare tumor is sometimes asymptomatic and is found at autopsy, but in some cases it may be confounded with a malignant tumor, as in the present case. The authors consider the angiomyolipoma as a choristoma rather than as a true neoplasm.
Adult↗
[Renal biopsy in the hemolytic-uremic syndrome in infancy. A study of three cases (author's transl)].
The hemolytic-uremic syndrome, although clearly described from the clinical and morphological points of view, has uncertain etilogy and pathogenesis for which various hypotheses have been advanced. In the immunohistochemical study of three recent infantile cases, whose clinical description and analysis follow those described in the literature, we found fibrinogen deposits, C3 and immunoglobulins in the walls and glomerular capillary vessels in two from which biopsies were taken early; while in the third case, in which the biopsy was taken a month after the process had begun, only fibrinogen was found. These findings suggest a pathogenesis of lesions involving an immunocomplex reaction with ulterior development of secondary intravascular coagulation. On the other hand, the presence or absence of C3 and immunoglobulins could be related to the timing of the biopsy, disappearing in the more developed cases. In the ultrastructural study performed in one of the case, besides other lesions habitually referred to, the presence of virus-like particles in the glomerular capillary endothelium was observed. Although having been seen in multiple locations and circumstances, this has not previously been described in the hemolytic-uremic syndrome, and it probably represents the morphological expression of degenerative glomerular processes.
Child, Preschool↗
Preformed mRNA in Cotyledons of Ungerminated Seeds of Cicer arietinum L.
Polyadenylated RNA was isolated from total RNA extracted from cotyledons of ungerminated or 18-hour-germinated chick-pea seeds by affinity chromatography on oligo(dT)-cellulose. Both poly(A)-containing RNA fractions exhibited a template activity when assayed in two cell-free translation systems, wheat germ extracts, and nuclease-treated reticulocyte lysates. Translation of preformed mRNA from cotyledons of dry seeds was completely abolished in the presence of several inhibitors of polypeptide chain initiation and also in the presence of the two "cap" analogues m(7) GTP and m(7) GMP. The patterns of polypeptides synthesized by translation of poly(A)-containing RNAs from cotyledons of ungerminated or 18-hour-germinated seeds, in the wheat germ system, analyzed by electrophoresis and autoradiography, were similar but not identical. It is concluded that cotyledons of dry Cicer arietinum L. seeds contain preformed mRNA.
Journal Article↗
[Effects of anabolizing 17 alkylating steroids in the treatment of various experimental hepatopathies. Morphological study].
Explore the source record for details and available documents.
Animals↗
Nonchromaffin paraganglioma of the duodenum.
A benign nonchromaffin paraganglioma of the duodenum is described and compared with other reported cases. Duodenal location is extremely rare but the morphology, based on the optical microscopic pattern (Zellballen) and the ultrastructural appearance is, comparable with paragangliomas of other sites. The lack of nerve fibres and ganglion cells in this tumour, together with the absence of a positive chromaffin reaction permits us to classify it as a pure nonchromaffin paraganglioma. This finding constitutes indirect evidence of the probable existence of a paraganglion in the duodenal wall, a structure not yet demonstrated in the adult.
Duodenal Neoplasms↗
Mixed Brenner and adenomatoid tumor of the testis: an ultrastructural study and histogenetic considerations.
A previously unreported association of Brenner and adenomatoid tumor found in the tunica vaginalis testis is presented. Many ultrastructural features found in mesothelial cells such as intercellular spaces, deeply indented nuclei, tonofilaments and tight desmosomes, were also shared by cells present in both neoplastic patterns. The previous histogenetic origins ascribed to testicular Brenner tumors are discussed and the evidence for their origin in the mesothelium considered.
Adult↗
Necrotizing sialometaplasia affecting the minor labial glands.
A case of necrotizing sialometaplasia of the lower lip, a previously unreported location for this lesion, is presented. In the past, other cases of this benign process occuring in this site may have been confused with squamous-cell or mucoepidermoid carcinoma. In order to arrive at the correct diagnosis, an ample biopsy of the lesion is mandatory.
Carcinoma, Squamous Cell↗