A Matri | PubMed Health

PubMed1995

[Methicillin resistant Staphylococcus aureus. Decrease of incidence in a medical resuscitation unit at CHU Charles-Nicolle in Tunis].

Methicillin-resistant Staphylococcus aureus (MRSA) is a major pathogen in hospitals. Between 1985 to 1988, there has been an increase in the number of MRSA (92 %) caused by an epidemic emergency in medical care unit of our hospital. Infections control measures allowed to stop these outbreaks (20 % MRSA in 1990). But incidence of MRSA persist to decrease without supplement control measures and in 1994, only 7 % of Staphylococcus aureus strains are MRSA.

Cross Infection↗

PubMed1992

[Staphylococcus aureus nosocomial infections in an intensive care milieu (1985-1989) in Tunis].

221 strains of Staphylococcus aureus oxacillin resistant (MetiR) caused nosocomial infections were isolated from 1985 to 1989 in a medical intensive care unit. The survey of susceptibility to antibiotics was established according to the computerized data of disk susceptibility test. The resistance phenotypes to beta-lactams, aminoglycosides and macrolides were established for epidemiological study. S. aureus infections were mainly bacteraemia (31%) and peritonitis (12%). These isolates were resistant to oxacillin with a high level (mean MIC 386 micrograms/ml). Their resistance phenotypes were MLSBc (constitutive resistance to macrolides, lincosamine and streptogramines B) in 53% and S + KGT (resistance to streptomycin, kanamycin, gentamicin and tobramycin) in 61%. All the isolates were susceptible to pristinamycin and vancomycin (MIC 0.1 and 2 micrograms/ml). These phenotypes related to the spread of multiply drug resistant strains were responsible of nosocomial outbreaks. Strains with the same pattern of resistance were isolated among the medical staff and in the environment. Infection control measures allowed to stop these outbreaks.

Cross Infection↗