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Biomedical subjects

A Mattiello

Publications and source records attributed to A Mattiello.

At least 19 recordsLinked to original sources
PubMed2001

Urokinase-type plasminogen activator up-regulates the expression of its cellular receptor through a post-transcriptional mechanism.

We have recently reported that the urokinase-type plasminogen activator (uPA) up-regulates the cell surface expression of its own receptor (uPAR) in several cell types, independently of its enzymatic activity. uPA has no effect on kidney 293 cells which do not express uPAR and then cannot bind uPA. Kidney cells, transfected with the coding region of uPAR cDNA, express very large amounts of uPAR and respond to uPA stimulation by regulating uPAR both at mRNA and protein levels. uPA effect occurs also in the presence of the transcriptional inhibitor dichloro-ribobenzimidazole, whereas it is abolished by the protein synthesis inhibitor cycloheximide. Moreover, uPA-dependent uPAR up-regulation correlates with the increase of a complex between the coding region of uPAR mRNA and an unknown cellular factor. We then propose that uPA regulates uPAR expression at a post-transcriptional level, by promoting the binding of uPAR mRNA to a stabilizing factor.

3' Untranslated Regions↗
PubMed1991

Efficacy and safety of teicoplanin in gram-positive pulmonary infections.

Teicoplanin is a new antibiotic obtained from a culture filtrate of Actinoplanes teichomyceticus with potent activity against aerobic and anaerobic gram-positive bacteria and having a high affinity for healthy or inflamed bronchial mucosa and pulmonary parenchyma. To investigate the efficacy and safety of this drug, we selected 13 patients suffering from lower respiratory tract infections caused by gram-positive organisms. Pathogens isolated from sputum or bronchial aspirate were: 8 Staphylococcus aureus, 1 Staphylococcus epidermidis, 3 Streptococcus pneumoniae and 1 Streptococcus species. We began treatment as monotherapy at the dosage of 400 mg daily (200 mg x 2) I.M. only after microbiological evaluation. 11 patients (84.6%) were clinically and bacteriologically cured, 1 (7.7%) showed definite clinical improvement but persistence of causative agent and 1 (7.7%) failed to respond. The mean treatment period was 8.3 days. No major adverse effect was observed. We conclude that teicoplanin is a very efficacious and well-tolerated antibiotic for therapy of gram-positive pulmonary infections.

Adult↗
PubMed1988

Hematoporphyrin binding to cultured aortic smooth muscle cells from spontaneously atherosclerotic turkey.

Porphyrins are known to be accumulated in vivo by tumors and atherosclerotic plaques. We studied the interaction of cultured aortic smooth muscle cells (SMC) from spontaneously atherosclerotic Broad Breasted White Turkeys (BBWT) with free hematoporphyrin (Hp) and low density lipoprotein (LDL)-Hp complexes. A significantly higher binding of LDL-Hp to SMC as compared to free Hp was observed. These data indicate that porphyrin binding to vascular SMC represents a possible mechanism for porphyrin accumulation by atherosclerotic plaques. This process is mediated, at least in part, by LDL.

Animals↗
PubMed1988

Lipoprotein binding to cultured aortic smooth muscle cells from normotensive and hypertensive rats.

Little is known about the pathophysiological mechanisms responsible for the higher incidence of atherosclerosis in hypertensive subjects. In view of the known atherogenic role of low-density lipoproteins (LDL), the aim of the present study was to evaluate possible differences in LDL binding to cultured aortic smooth muscle cells from normotensive and hypertensive rats. We studied the time-dependence and dose-dependence of LDL binding to both cell types. Low density lipoprotein binding to smooth muscle cells from the hypertensive rat was significantly higher than that to smooth muscle cells from the normotensive rat. This mechanism might explain the higher incidence of atherosclerotic lesions observed in hypertension.

Animals↗
PubMed1988

Retention of haematoporphyrin in the aorta of hypertensive rats: in-vivo and in-vitro studies.

Porphyrins are known to be accumulated and retained by tumours and atherosclerotic plaques. This property has been used for a new therapeutic approach called photodynamic therapy. In this study we assessed whether the presence of arterial hypertension could modify porphyrin turnover in the vascular wall. At various times after intravenous injection, haematoporphyrin concentration was assessed by a spectrophotofluorimetric method in the aortas of normotensive and hypertensive rats. Moreover, we studied the binding of haematoporphyrin to cultured smooth muscle cells obtained from normotensive and hypertensive rats. Larger amounts of haematoporphyrin were accumulated by the aorta of hypertensive rats and cleared at a slower rate, compared with normotensive rats. As for in-vitro experiments, cultured smooth muscle cells from hypertensive rats bound larger amounts of haematoporphyrin than cells from normotensive rats.

Animals↗
PubMedDate not supplied

[Tumor markers in lung neoplasms].

The authors studied the variations of the markers isolated or in differently associations, in pulmonary pathology. The results from linear multivaried analysis, applied to CER, TPA, Ca 125, Ca 15.3 and calcitonin, are particularly interesting in diagnosis.

Adult↗
PubMedDate not supplied

[Yersinia enterocolitica sepsis in splenectomized thalassemic subjects. Description of 2 cases].

Two cases of Yersinia enterocolitica septicemia in two splenectomized children with thalassemia major are reported. Human Yersinia enterocolitica septicemia is an uncommon condition, but its frequency may increase in patients having debilitating diseases or blood disorders, as well as a consequence of the splenectomy. Some brief considerations on the pathogenetic factors yielding, to severe infections in splenectomized thalassemic children are discussed. The high number of thalassemic people in Italy makes necessary an early diagnosis in case of septicemia. Particularly important is the blood culture, because of the slowness of the microbic development in stools.

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