Biomedical subjects
Publications and source records attributed to A Mauran-Sendrail.
Haemoglobin Ouled Rabath found only once before in an Algerian has been discovered at high frequency in the Kel Kummer Tuaregs in Mali. The tribe represents a 'genetic isolate'.
This work shows the higher probability for some individuals of having Hp O phenotype: that is, children under twelve, and individual carriers of haemoglobin S (haemoglobin D carriers do not present this characteristic). This observation appears as a confirmation of the hypotheses explaining Hp O phenotype as a consequence of haemolytic anaemia. Besides, the test of two genetic models taking into account both Hp O and Hp21 M phenotypes leads to strong difficulties due to a certain irregularity of "haptoglobin" genetic system.
Electrophoretic analysis of hemoglobin types of 409 baboons of various species, mostly from Senegal, corresponds with the findings of other authors. Baboon hemoglobin is homogeneous as a whole, but differs electrophoretically from that of other monkey species. However, a difference in the electrophoretic mobility of the nonhemoglobin fraction of Papio anubis and Papio cynocephalus suggests a possibly different amino-acid sequence. This information may be useful for the classification in doubtful cases.
The haemoglobin types of 1487 of the East Senegal Bedik and Niokholonko populations have been studied. There are significant differences between them, the most likely explanation of which is that the populations are of different origins. The Bedik appear to be the most ancient known settlers in East Senegal: they possess only A and S haemoglobins. The Niolholonko came later, probably from Mali: they have a lower frequency of S genes but AC and AD phenotypes are also encountered among them.
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