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Biomedical subjects

A McClure

Publications and source records attributed to A McClure.

6 recordsLinked to original sources

Peri-incisional mezlocillin versus rectal-metronidazole for wound infection prophylaxis.

One hundred and forty patients who underwent appendicectomy were included in a prospective randomized trial to compare the ability of preoperative rectal metronidazole and peri-incisional mezlocillin to prevent wound infection following appendicectomy. The results show that bactericidal local tissue levels of mezlocillin were uniformly achieved using the peri-incisional technique. The wound infection rate for the metronidazole group was found to be 15.9% and did not significantly differ from the wound infection rate when mezlocillin was used (10.4%). Peri-incisional mezlocillin therefore appears to be a viable prophylactic technique against wound infection following appendicectomy and may offer a cheaper alternative to intravenous intra-operative metronidazole administration in cases when pre-operative metronidazole suppositories have been omitted. The peri-incisional mezlocillin technique is also suitable for routine prophylaxis against wound infection following appendicectomy.

Adolescent

Factors associated with psychiatric morbidity in men--a general practice survey.

A survey of men aged from 20 to 59 years from a general practice list using the General Health Questionnaire and a questionnaire of social and domestic items yielded 1011 respondents. Several items were shown to be linked with psychological disturbance including ill health, ill health or psychiatric history in wife, poor relationship with wife, being unemployed, poor or divorced and lower social class. The results are compared with those of a similar sample of women.

Adult

Computer-controlled anesthetic delivery system.

We designed and tested a computer-controlled syringe pump for the administration of volatile anesthetics into a closed breathing circuit. The system consists of a small computer, a flip-flop circuit, and an automatic syringe pump. The computer was programmed to administer liquid anesthetics according to the square root of time model of anesthetic uptake. A simple electronic flip-flop circuit connected the computer to the syringe pump. Safeguards to prevent accidental anesthetic overdosage and algorithms to provide for dosage changes based on patient response were written into the program. After testing, the system was used to administer anesthetics to ten patients undergoing surgical procedures. The anesthetic uptake deviated from the square root of time model after approximately two hours. The system provided smooth and reliable administration of volatile anesthetics during closed circuit anesthesia.

Adult

Factor analysis and validation of the General Health Questionnaire in men: a general practice survey.

As part of a survey of 1011 men aged 20-60 years, a factor analysis and validation study of the General Health Questionnaire (GHQ) was carried out. Three clinically relevant factors could be isolated but factor analysis did not generally enhance the value of the GHQ. When compared with results for a similar group of women, sex differences in answering the GHQ were found; the GHQ was perhaps a less satisfactory screening instrument in the men.

Adult

Infant Gesell scores vs. cognitive skills at age 12 years.

In an earlier study, it was found that infant performance on the Gesell correlated better with performance on nonverbal than verbal cognitive skills up to the age of 5 years. Recently, the same 26 male middle-class Ss, now 12 years old, were retested with the WISC-R, WRAT, and PPVT. Performance on the Gesell was found to relate significantly to WISC-R Performance IQ and to a lesser extent to PPVT IQ, but did not relate to WISC-R Verbal IQ nor to performance on the WRAT. The results suggest that the Gesell has a better predictive validity for nonverbal than verbal cognitive skills.

Child