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Biomedical subjects

A Melkild

Publications and source records attributed to A Melkild.

7 recordsLinked to original sources
PubMed1994

[Ring chromosome 21 as a cause of developmental disorder. A case report from the practice of child psychiatry].

Ring chromosome 21 is a very rare chromosomal abnormality known to cause a great variety of clinical findings. Persons with ring chromosome 21 can be intellectually and phenotypically normal, but this abnormality is found more often in persons with dysmorphic features, malformations and mental retardation. Ring chromosome 21 is also encountered as the only chromosomal abnormality in individuals with Down syndrome. We describe a four year old girl with ring chromosome 21 (karyotype 46,XX/46,XX,-21, +r(21)), who was examined in a department of child psychiatry because of delayed development. The child had serious speech and language problems, slightly dysmorphic features and bilateral hip-joint dysplasia.

Child Psychiatry↗
PubMed1989

[The general population as a reference group. A discussion of the concept of the healthy worker effect].

In cohort studies concerning occupational diseases the general population is a commonly used reference entity in countries with national cancer registries or census bureaus. However, former and present employees regularly experience lower disease incidence than the general population, even in occupations with exposures known to cause adverse health outcomes. This phenomenon is often referred to as the "healthy worker effect". The concept is discussed in the present paper.

Cohort Studies↗
PubMed1989

Incidence of cancer among welders and other workers in a Norwegian shipyard.

The incidence of cancer among 4778 male shipyard workers, including 783 mild steel welders, was investigated in a historical cohort study. The workers had been employed for at least three months between 1 January 1946 and 31 March 1977. The incidence of cancer was observed from 1 January 1953 through 1986. The loss during follow-up was only 0.9%. There were 53 observed cases of lung cancer in the whole cohort versus 31.3 expected on the basis of the national rates for men. There was an increased incidence of lung cancer among the welders, with seven observed cases versus 3.2 expected. Twenty-two cases of bladder cancer were observed versus 15.2 expected. Two malignant mesotheliomas had occurred (0.7 expected). Smoking was likely to be a confounder in the present study. Due to concomitant exposure to asbestos, the results are inconclusive concerning the possible relationship between exposure to welding fumes and lung cancer.

Air Pollutants, Occupational↗
PubMed1984

Prazosin ('Peripress'): a long-term study.

A long-term follow-up study was carried out in 90 patients with moderate to severe hypertension to evaluate the effectiveness of prazosin given alone or as part of combined treatment with other antihypertensive agents. The aim was to obtain and maintain adequate blood pressure control with as few side-effects as possible. Treatment was discontinued during the first year in 11 cases, 9 because of side-effects and 2 for other reasons. The remaining 79 patients were kept under observation for an average period of 5.3 years (range 3 to 6 years) while being treated with prazosin. Of these, 19 had previously suffered serious cardiovascular complications. The results showed that prazosin proved adequate as sole medication in 6 patients during the entire observation period and satisfactory reduction of blood pressure (less than 90 mmHg diastolic) could be achieved and maintained in over 80% of patients with a combination of prazosin and beta-blockers, with supplementary treatment with diuretics in some cases as and when necessary because of fluid retention and consequent loss of efficacy. Dosage was adjusted to individual needs and a striking feature of the results was the decreasing dose requirement, a trend which was most marked after 2 years of treatment. Over-dosage occurred in a few cases for this reason but treatment, in general, was well-tolerated, most side-effects occurring during the first year.

Adult↗