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A Mellemgaard

Publications and source records attributed to A Mellemgaard.

52 records · Page 3Linked to original sources
PubMed1991

[Tumors of the renal pelvis and ureter in Denmark in the period 1943-1986. Cancer statistics no. 28].

A review based on data from the Cancer Register reveals that the age-standardized incidence rate of tumours of the renal pelvis and ureter in Denmark has increased more than ten-fold where both men and women are concerned during the 40 year period from 1943 to 1982. A random control sample suggest underreporting of pelvic tumours of 8% and it is known from previous investigations that 95-98% of all known cases of tumour are registered in the Cancer Register. These circumstances suggest a greater increase in the incidence than that registered in the present article. Where tumours of the renal pelvis in men are concerned, however, the development was reversed in the middle of the nineteen seventies with a decrease in the incidence continuing to the conclusion of the period of this review in 1986. The decrease in tumours of the renal pelvis in men is observed particularly in the capital and in rural districts. A possible cause of this decrease is reduction of tobacco consumption in men. The incidence of tumours of the ureter in men is still increasing but the account is based on few observations. Possible reasons for the uninterrupted increase in incidence of tumours of the renal pelvis and ureter in women continuing until the conclusion of the period of registration is the increasing tobacco consumption which has been observed in women and consumption of phenacetin before this preparation was deleted from the drug register in Denmark.

Adult↗
PubMed1991

[Metachronous colorectal cancer].

The occurrence of metachronous colo-rectal cancer was investigated in 903 patients under the age of 40 years at the time of diagnosis of the primary cancer. A constant frequency of metachronous colo-rectal cancers was found and a cumulated incidence of 30% after an observation period of 41 years. Metachronous cancer of the colon was encountered most frequently in the right half of the colon regardless of the site of the primary cancer. On the basis of the above mentioned results, a life-long follow-up programme is recommended, consisting of regular examination for blood in the faeces and colonoscopy.

Adenocarcinoma↗
PubMed1991

Metachronous colorectal cancer in young patients: expression of the hereditary nonpolyposis colorectal cancer syndrome?

The cumulative incidence rate of metachronous colorectal cancer in patients younger than 40 years of age at diagnosis of the primary cancer has been shown to be 30 percent. Metachronous colorectal cancer is predominantly located in the right colon with a decreasing frequency toward the rectum. The risk of developing a metachronous colorectal cancer was found to be 16-29 times increased when compared with the risk of having a primary colorectal cancer. Because of the resemblance between characteristics of metachronous colorectal cancer and the features of hereditary nonpolyposis colorectal cancer (HNPCC), it is proposed that young colorectal cancer patients developing metachronous colorectal cancer could in fact be HNPCC patients.

Adolescent↗
PubMed1990

[Renal cancer in Denmark in 1943-1986. Cancer statistics number 27].

During the past 45 years, the number of new cases of parenchymatous renal cancer have increased from approximately 230 to over 500 per annum. The incidence of renal cancer increased until the middle of the nineteen seventies, after which it stagnated. Parenchymatous renal cancer is nearly twice as frequent in men. During the entire period, Wilms' tumour and sarcoma have been very rare with only few new cases every year.

Adenocarcinoma↗
PubMed1990

Age at first birth, parity and risk of breast cancer: a meta-analysis of 8 studies from the Nordic countries.

Several large epidemiological studies in the Nordic countries have failed to confirm an association between age at first birth and breast cancer independent of parity. To assess whether lack of power or heterogeneity between the countries could explain this, a meta-analysis was performed of 8 population-based studies (3 cohort and 5 case-control) of breast cancer and reproductive variables in the Nordic countries, including a total of 5,568 cases. It confirmed that low parity and late age at first birth are significant and independent determinants of breast-cancer risk. Nulliparity was associated with a 30% increase in risk compared with parous women, and for every 2 births, the risk was reduced by about 16%. There was a significant trend of increasing risk with increasing age at first birth, women giving first birth after the age of 35 years having a 40% increased risk compared to those with a first birth before the age of 20 years. Tests for heterogeneity between studies were not significant for any of the examined variables. In the absence of bias, this suggests that several individual Nordic studies may have had too little power to detect the weak effect of age at first birth observed in the meta-analysis.

Breast Neoplasms↗
PubMed1990

Metachronous colorectal carcinoma.

During the period 1943-67, 903 Danish patients aged less than 40 years had colorectal carcinoma. The patients were followed up for up to 41 years and during this period 44 of 501 (9 per cent) operated on for cure developed a metachronous colorectal carcinoma. The cumulative risk of a metachronous colorectal carcinoma was 30 per cent after up to 41 years of observation. The occurrence of a metachronous colorectal carcinoma was evenly distributed in the observation period. The cumulative survival rate after operation for a metachronous colorectal carcinoma was 41 per cent after 20 years of observation. We propose a lifelong follow-up programme after resection of colorectal carcinoma for cure in this age group, including annual Hemoccult test and colonoscopy at 3-year intervals.

Adult↗
PubMed1990

The association between risk of breast cancer and age at first pregnancy and parity in Maribo County, Denmark.

The effect of age at first pregnancy and number of pregnancies was examined in a cohort of 14,421 women where reproductive informations were collected as part of a cervical cancer screening program. A total of 352 cases occurred in the cohort. In subgroups of women defined by age at first pregnancy the relative risk of breast cancer was lower among women who were first pregnant before 25 years of age (RR = 0.85 vs 1.20). In subgroups of women defined by parity the relative risk decreased with increasing number of pregnancies from about unity among women with 0-3 pregnancies to 0.7 among women with 6 or more pregnancies.

Adult↗
PubMed1989

Cancer incidence among spouses of patients with colorectal cancer.

The risk of colorectal cancer was examined among spouses of approximately 10,000 colorectal cancer patients. A total of 8,095 spouses were identified, and cancer cases in this cohort were sought in the Danish Cancer Registry. No excess risk was found for colorectal cancer as such. The data were also analyzed by subsite of the large bowel for the index cases and for the spouses, respectively. The estimated relative risks were in general close to unity, the only exception being the risk of right-sided colon cancer among husbands of index cases with left-sided colon cancer, RR = 2.17 (p less than 0.05). The absence of excess risk was noted regardless of the duration of marriage. The risk of other cancers with a presumed etiology similar to that of colorectal cancer (cancer of the uterine corpus, breast, prostate and biliary tract) was also close to expected values.

Colorectal Neoplasms↗
PubMed1988

Measuring progress against cancer.

The trends in age-specific cancer incidence and mortality rates in Denmark were evaluated over the period 1951-1980. The total incidence of cancer increased in all age-groups in both sexes, i.e. the life-time risk for any person of getting a malignancy has been increasing. The mortality from cancer shows a different pattern, especially in the younger age-groups where cancer mortality has been decreasing. The decrease in incidence of gastric cancer, when measured in terms of incidence or mortality rates, has been an important source of success. Screening for precancerous lesions of the cervix has been responsible for a large decrease incidence among younger women. Had it not been for the large increase in the incidence of lung cancer, the total cancer mortality in both sexes would, in nearly all age-groups, have been lower in 1976-1980 than in 1951-1955.

Adult↗
PubMed1988

Papillary thyroid carcinoma in Danish patients with familial adenomatous polyposis.

All patients from the nationwide Danish Polyposis Register have been followed up with regard to thyroid carcinoma. During the period 1943-1985, 2/107 Danish women and 0/138 men developed papillary thyroid carcinoma after the diagnosis of familial adenomatous polyposis. The expected number among females was 0.02 resulting in a observed/expected ratio of 100 (95% confidence limits 12-361). Consequently, thyroid carcinoma should be included among the extracolonic lesions, which may develop in any female polyposis patient. However, regular thyroid examination is not indicated, as thyroid carcinoma is uncommon and as the prognosis is excellent.

Adenomatous Polyposis Coli↗
PubMed1988

High and low risk groups for cancer of colon and rectum in Denmark: multiplicative Poisson models applied to register linkage data.

Multiplicative Poisson models were used to identify subgroups of the Danish population at high and low risk of developing cancer of the right or left side of the colon, and cancer of the rectum. The analysis was based on cross-linked data from the 1970 census and the Danish Cancer Registry, where a 10-year follow-up period yielded some 20,000 colo-rectal cancers, in approximately 2.5 million persons. The risk of cancer of the right side of the colon in longer educated men living in apartment houses was almost twice as high as in farmers living in single family houses (relative risk 1.84; 95% confidence interval 1.42-2.37). A two-fold ratio (RR 2.18; 95% CI 1.70-2.62) was also seen in the risk of cancer of the left side of the colon between men with longer education in Greater Copenhagen and farmers in Jutland. The annual number of colon cancer cases in men in Denmark could be reduced by 27% if the incidence for all men was equal to that found for the low risk group of farmers.

Adult↗