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Biomedical subjects

A Midwinter

Publications and source records attributed to A Midwinter.

14 recordsLinked to original sources
PubMed1994

Cytological changes associated with tubo-endometrioid metaplasia of the uterine cervix.

Two women who had undergone previous cervical surgery for the treatment of glandular intraepithelial neoplasia (GIN) and cervical intraepithelial neoplasia (CIN), were found to have severely dyskaryotic cells of glandular and metaplastic type in follow-up cervical smears. A third patient was found to have similar abnormal cells in a routine screening smear. All of the patients were subjected to either hysterectomy or cervical conization and in all cases histological examination showed tubo-endometrioid glands in the endocervix, well away from the uterine isthmus, with no associated endometrial stromal tissue. All of the cervical smears were reviewed and cytological features that facilitate the distinction between tubo-endometrioid metaplasia and squamous or glandular dyskaryosis were identified. These features include the smaller size of affected cells, more marked nuclear hyperchromasia, inconspicuous nucleoli, the formation of glandular structures, the lack of discrete squamous dyskaryosis and the absence of the typical 'feathering' noted with GIN. The possibility of tubo-endometrioid metaplasia should be considered when atypical glandular or metaplastic cells are noted in cervical smears, particularly, but not exclusively, in women who have been treated for CIN or GIN. In the presence of these changes clinicians should rebiopsy the cervix before embarking on further unnecessary surgery which may adversely affect fertility and pregnancy, particularly in younger patients.

Adult↗
PubMed1994

Characterization of an antigenic oligosaccharide from Leptospira interrogans serovar pomona and its role in immunity.

An antigenic oligosaccharide fraction derived from the lipopolysaccharide of Leptospira interrogans serovar pomona was isolated by endo-glycosidase H digestion and column chromatography. The oligosaccharide contained rhamnose, ribose, glucose, and glucosamine and inhibited the binding of opsonic, protective monoclonal antibodies directed against the lipopolysaccharide. When conjugated to diphtheria toxoid, the oligosaccharide elicited the production of agglutinating, opsonic antibodies.

Agglutination↗
PubMed1990

Vaccination of mice with lipopolysaccharide (LPS) and LPS-derived immuno-conjugates from Leptospira interrogans.

Mice were vaccinated with lipopolysaccharide (LPS) from Leptospira interrogans serovar pomona or hardjo, or with the polysaccharide (PS) fraction of the LPS, or with an immunoconjugate of PS and diphtheria toxoid (DT). Maximum agglutinin titres were found 6-10 weeks after vaccination with LPS or PS-DT conjugate; the latter elicited antibody titres at least 10 times higher than those produced in response to LPS. Animals failed to react significantly to PS. Titres elicited by antigens of serovar pomona were higher than those elicited by serovar hardjo.

Animals↗
PubMed1982

Routine real-time scanning at the first hospital visit.

All patients presenting at one consultant booking antenatal clinic had a routine real-time ultrasonic scan. The purpose was to study the accuracy of the technique, the additional work involved and the clinical benefit. All scans were performed by one operator. The average time per scan was 6 min compared with 15 min for each B scan. When gestation assessed by scan differed from gestation assessed by menstrual dates or clinical examination, an independent assessment was made after birth. There was a marked decrease in utilization of B-scanning facilities. Routine real-time scanning at the first visit was a reliable method of assessing gestation in 94% of patients.

Female↗
PubMed1973

It's your age.

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Estrogens↗