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Biomedical subjects

A Milligan

Publications and source records attributed to A Milligan.

15 recordsLinked to original sources
PubMed1991

Trichothiodystrophy.

We describe a case of classic trichothiodystrophy occurring as an isolated disorder. This is the second reported case of trichothiodystrophy unassociated with systemic disorders, in contradistinction to other cases where there have been profound associated neuro-ectodermal abnormalities. The hair has shown the pathognomonic polarizing light-microscopic findings and the sulphur content has been confirmed to be reduced to approximately 50% by energy dispersive X-ray micro-analysis. Formal light-microscopic studies of hair cross-sectional shape using a Hardy microtome have confirmed the previous finding of a very thin or absent cuticle. An additional previously unreported finding was a 'scalloped' contour in a majority of hairs. The previously described ribbon shape could not be confirmed. Follow-up observation of the patient has shown clinical improvement with time.

Alopecia↗
PubMed1990

The use of chlorambucil in the treatment of bullous pemphigoid.

Twenty-six patients with bullous pemphigoid were treated with a combination of chlorambucil and a systemic corticosteroid; 23 completed treatment. The corticosteroid requirement during therapy was reduced by 50% compared with that reported for corticosteroid and azathioprine, and the mean total duration of therapy was only 5 months. The side effects of chlorambucil have not been significant, but in 30% of the patients a mild transient thrombocytopenia developed. In one patient a more significant marrow suppression developed. Despite complete recovery, chlorambucil treatment was discontinued in this patient. There was no evidence that either the disease treated in this way or the treatment itself had an adverse effect on survival during therapy or for the mean follow-up period of 36 months. Patients who responded less well to treatment tended to be younger, and their disease was more severe in that a higher dosage was required for initial control. Patients in whom thrombocytopenia developed were older and had lower pretreatment platelet levels.

Age Factors↗
PubMed1990

Epidermal dendritic S100 positive cells in necrobiosis lipoidica and granuloma annulare.

Using an antibody to S100 protein, the number of dendritic cells above the basal layer in the epidermis was assessed in necrobiosis lipoidica and granuloma annulare. A statistically significantly higher number of these cells was found within the epidermis in necrobiosis lipoidica compared with granuloma annulare and normal skin. The numbers were similar to those seen in sarcoidosis and tuberculous reactions in the skin, which raises the possibility of an immune pathogenesis for necrobiosis lipoidica.

Cell Count↗
PubMed1990

Lichen planus in children--a review of six cases.

We present the features of six children who have been seen amongst 154 consecutive new patients with lichen planus in our outpatients clinic. All but one of the children had unusual forms of the disease and there was a family history of lichen planus in three. Lichen planus is rare in childhood and often assumes atypical clinical patterns.

Adolescent↗
PubMed1989

Prolidase deficiency: a case report and literature review.

We describe a patient in whom chronic leg ulceration was due to prolidase deficiency. The clinical features of this condition are described and we discuss the metabolic abnormality and the treatment regimes which have been employed. We also report the further finding of erosive cystitis, which we consider should be added to the list of clinical features of prolidase deficiency.

Adolescent↗
PubMed1988

Ectopic cutaneous schistosomiasis and schistosomal ocular inflammatory disease.

We describe a patient with unilateral ectopic cutaneous schistosomiasis as a feature of Schistosoma mansoni infection. In addition to skin lesions he also suffered from schistosomal ocular inflammatory disease. The infection appeared to have been acquired during a visit to Tanzania. Ectopic cutaneous lesions usually affect the perineal area or trunk, and our patient is unusual in the localization of his skin lesions to the forehead.

Adolescent↗
PubMed1988

Erythropoietic protoporphyria exacerbated by oral iron therapy.

Four patients with erythropoietic protoporphyria (EPP) are reported, in whom oral iron produced clear-cut clinical and biochemical deterioration. This suggests that there are two biochemically and genetically distinct sub-groups of EPP patients distinguished by their dramatically different response to oral iron.

Adult↗