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Biomedical subjects

A Mirka

Publications and source records attributed to A Mirka.

6 recordsLinked to original sources

Clinical application of dynamic posturography for evaluating sensory integration and vestibular dysfunction.

The assessment of sensory organization in balance control by dynamic posturography is unique compared with clinical maneuvers and other vestibular or neurologic testing. It was designed to isolate the relative contributions of visual, somatosensory, and vestibular feedback, and thus to assess the overall function of the balance control system in adaptively selecting between available sensory information for orientation cues to serve as a reference to earth vertical. Rather than serving as a test for specific pathologic conditions, the utility of posturography is in screening for balance disorders and in functionally defining different types of sensory deficits or central disorders. This functional information can be used to define restrictions or high-risk environments for patients, to guide rehabilitative balance therapy, and to monitor progression of recovery from a disease process.

Adolescent↗

Prednisone-induced worsening of neuromuscular function in myasthenia gravis.

In patients with myasthenia gravis who received single doses of prednisone orally (40 to 100 mg), we found acute inhibition of neuromuscular function as manifest by increased decremental responses to repetitive nerve stimulation, reduced twitch tension, and lowered maximum voluntary contraction strength. The time course of these changes correlated with plasma methylprednisolone levels, implying direct drug effects on neuromuscular function.

Action Potentials↗

Components of postural dyscontrol in the elderly: a review.

The concept of a generalized aging effect on a generalized balance mechanism is discussed, and an alternative, multicomponent approach to understanding the heterogeneity of postural dyscontrol in the elderly is presented. Neural sensorimotor components of normal postural control mechanisms are identified and discussed. The effects of Parkinson's disease, hemiplegia, cerebellar degeneration, peripheral vestibular loss, and other disorders on the components of postural control are summarized. Quantitative posturography is advocated to detect preclinical manifestation of multiple musculoskeletal and neuromuscular pathologies and reduced compensatory abilities in posturally unstable elderly adults.

Aged↗