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Biomedical subjects

A Misumi

Publications and source records attributed to A Misumi.

46 records · Page 3Linked to original sources
PubMed1979

Postoperative evaluation of the exocrine function of the pancreas after pancreaticoduodenectomy.

The exocrine function of the residual pancreas of eight patients who underwent pancreaticoduodenectomy was studied with the 131I-triolein absorption test and by 75Se-selenomethionine scintiscanning. In six patients, a pancreaticojejunostomy was performed, while in the other two patients, the pancreatic duct of the residual pancreas was ligated. The fecal 131I-triolein excretory rate in the duct ligation group was more than 50 per cent, while, in all but one patient in the duct anastomosis group, it was less than 10 per cent. Pancreatic scintiscanning in the duct ligation group was negative before and after operation. All of the patients with anastomosis of the duct had an image of the pancreas before operation. However, postoperatively, scintiscanning of the pancreas was negative in two patients and became negative late in the postoperative period in four others without any decline of fat absorption. The cause for this postoperative change in scintiscanning of the pancreas and the discrepancy of this finding with that obtained with the 131I-triolein absorption test remains to be studied.

Duodenum↗
PubMed1978

Evaluation of fibergastroscopic biopsy in the diagnosis of gastric cancer: a study of 339 cases.

Three hundred and sixty-five biopsies under direct vision, using a fibergastroscope, were performed on 339 patients with gastric cancer from 1966 to 1975. Diagnostic accuracy improved with an increased in the number of biopsy specimens and reached 100% when 6 or more biopsy specimens were obtained. Positive specimens were obtained with 48.5% of the biopsied tissue from the center of the lesion (A), 52.2% from the inner margin of the lesion (B1), 19.6% from the outer margin of the lesion (B2), and 1.6% from the area around the lesion (C). The combined result of the biopsies from A and B1 was highly positive in 49 out of 51 cases (96.1%). Diagnostic accuracy of the early cancer reached 96.9%. This was significantly higher than that of advanced cancer (80.3%). False negative biopsies were found in 51 (16.3%) of the 313 patients who were gastrectomized and diagnosed by histological examinations. Twenty-three of the 27 patients, who were diagnosed as benign either by x-ray or endoscopic examination, and 4 of the 5 patients who were diagnosed as benign under both examinations, were found to have positive results by biopsy. Positive biopsy examination was particularly helpful with patients showing on inconclusive or benign diagnosis by x-ray and/or endoscopic examinations.

Biopsy↗
PubMed1977

Percutaneous transhepatic bile drainage.

Percutaneous transhepatic bile drainage was performed in 13 patients with obstructive jaundice, using a combination of the PTC technique and a Seldinger angiography catheter. In 11 cases, the outflow of bile through the catheter was satisfactory and complications were few. Since the risk of the procedure is low and it can be done without laparotomy, it is an ideal technic for biliary decompression before attempting to do a resection. Also, repeated cholangiography through a catheter which is left in place is helpful as a diagnostic aid before and after surgery.

Aged↗
PubMedDate not supplied

A biometrical study on esophageal invasion of carcinoma of the upper stomach. Part II: Radiographic evaluation of esophageal invasion on the basis of its occurring point and size.

Esophageal invasion of upper stomach cancer was analized on the resected specimen based on its occurring point and size. The distance of esophageal invasion was calculated by subtracting the distance between the occurring point and esophagogastric junction (EJG) from the radius of the cancer on the preoperative X-ray films. Fifty-six (76.7%) out of 73 resected cancers of the upper stomach invaded the esophagus. The average distance of invasion was 19.8 +/- 12.7 mm; the longest distance was 64.0 mm. The shorter was the distance of the occurring point from the EGJ, the longer was the esophageal invasion. The calculated distance of esophageal invasion of the cancer was correlated significantly with its histological distance (p less than 0.01). The distance of esophageal invasion can be seen with acceptable accuracy on the X-ray films preoperatively, even when the proximal edge of esophageal invasion is not clear on the films.

Adenocarcinoma↗
PubMedDate not supplied

A biometrical study on esophageal invasion of carcinoma of the upper stomach. Part I: Determination of occurring point of the cancer and analysis of its horizontal extension.

In order to detect the occurring point of gastric cancer, and to determine its horizontal extension from this point, we performed a histological examination of 30 resected specimens of upper stomach cancer and 31 of middle and lower stomach cancers. The center of the horizontal extension (Oh) and that of the vertical extension (Ov) were calculated using a paper model. The mean distance between Ov and Oh (Ov-Oh D) was as little as 5.7 +/- 5.0 mm, and the ratio of Ov-Oh D to the size of the lesion was as low as 8.3 +/- 6.7%. There was a linear correlation between the oral and anal radii of the cancer. There was also a linear correlation between anterior and posterior radii of the cancer. In conclusion, either the Oh or the Ov can be considered as the occurring point, and the cancer grows concentrically around this point.

Adenocarcinoma↗
PubMedDate not supplied

The effect of iron on experimental colorectal carcinogenesis.

The effect of parenteral and oral iron was examined in the rat 1,2 dimethylhydrazine (DMH) colorectal carcinogenesis model in a series of experiments. Parenteral supplementation of iron was found to augment tumor yield (p = 0.012) and oral iron was found to augment tumor incidence (p = 0.03, when control groups were combined). In addition, phytic acid, a significant component of dietary fiber was found to reverse the augmenting effect of oral iron on tumor yield and incidence (p = 0.09 for both). Furthermore, in a short term DMH nuclear toxicity assay, analysis of the karyorrhectic index (KI), there was no difference in the KI between oral iron and phytate dietary groups (p = 0.53 for the left colon and p = 0.2 for the right colon), implying that iron's effect on colorectal tumor induction takes place during the promotional phase of carcinogenesis and not during initiation. These experiments support the epidemiologic observation that dietary iron may augment colorectal cancer risk and that the mechanism by which dietary fiber diminishes colorectal cancer risk may be the chelation of dietary iron by the phytic acid component of dietary fiber.

1,2-Dimethylhydrazine↗
PubMedDate not supplied

Transabdominal operation for carcinoma of the gastric cardia: application of pulling-up retractor and EEA stapler.

In order to ascertain the advantages of the combined use of the pulling-up retractor and EEA stapler, we reviewed 88 patients who underwent surgery for upper stomach cancer between 1978 and 1986. The length of resected esophagus was significantly longer in patients operated on using an abdominal approach with this combination, as in those using a thoracoabdominal approach, than in those who were operated on using an abdominal approach with only the retractor or without the instruments (p less than 0.05). A relatively high incidence of leakage occurred at the anastomosis of the esophagus to the stomach or jejunum following operation using a transabdominal approach without the instruments. Pulmonary complication tended to be decreased in the non-thoracotomized patients compared to the thoracotomized patients. Postoperative radiogram following the combined use showed an esophagogastrostomy at a high level in the mediastinum. Our combination technique enables lymphadenectomy in the lower mediastinum and a sufficiently long enough resection of the esophagus without fatal complications.

Anastomosis, Surgical↗