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Biomedical subjects

A Mo

Publications and source records attributed to A Mo.

22 records · Page 2Linked to original sources
PubMed1979

Esterification of cholesterol in human small intestine: the importance of acyl-CoA:cholesterol acyltransferase.

Human intestinal mucosa contains acyl-CoA:cholesterol acyltransferase activity. The enzyme has been studied by using oleylcarnitine, CoA and carnitine palmitoyltransferase as an oleyl-CoA regenerating system. The enzyme was found in the particulate fraction of the cells, it had a pH optimum between 7.2 and 8.2, and was inhibited by taurocholate. The specific enzymic activity in biopsies from intestinal mucosa of normal men was found to be 3.6 +/- 1.37 nmol cholesteryl ester formed mg protein-1 h-1, an activity which can account for all cholesteryl esters in intestinal lymph. Low enzymic activity was found in biopsies from patients with small intestinal disorders. Two pancreatectomized patients had values within the normal range.

Acyltransferases↗
PubMed1979

Effect of plasma H+-ion concentration on pancreatic HCO-3 secretion.

The relationship between the rate of pancreatic HCO-3 secretion and plasma H+-ion concentration was investigated in 15 pentothal anesthetized, secretin infused pigs (1.8 C.U./kg b.w. h-1, intravenously) during acute metabolic and respiratory acid-base disturbances. Pancreatic HCO-3 secretion increasd to 196 +/- 10% of control during alkalosis and fell to 41 +/- 4% of control during acidosis. Partial metabolic compensation of respiratory acidosis restored HCO-3 secretion to 87 +/- 6% of control. A proportional relationship was found between HCO-3 secretion and plasma pH. Different, proportional relationships were found between HCO-3 secretion and plasma HCO-3 concentration during metabolic and respiratory acid-base changes. HCO-3 secretion was independent of H+-ion concentration in pancreatic juice. Plasma H+-ion concentration, therefore, seems to determine the rate of pancreatic HCO-3 secretion. This finding supports the hypothesis that a proton pump is responsible for pancreatic HCO-3 secretion.

Acid-Base Equilibrium↗
PubMedDate not supplied

[Metastasis to the penis from carcinoma of the rectum. A clinical case].

Penile metastases are extremely uncommon, with less than 300 reported cases. The primary sites of the responsible carcinoma have been bladder, rectum, prostate, kidney, testis, lung, nasopharynx and melanoma in that order. We report a case confirming the same data: no therapy has been shown to be helpful, the prognosis is very poor, with an average survival of less than one year. On the other hand we pointed out the importance of CT scan as a diagnostic tool for assessing the spread of neoplasm.

Adenocarcinoma↗