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Biomedical subjects

A Mocarquer

Publications and source records attributed to A Mocarquer.

4 recordsLinked to original sources

[Pregnancy in a class-T diabetic patient].

We report the pregnancy of a 35 year old diabetic woman with a positive Australia antigen, 3 years after a successful cadaver kidney transplant. Immunosuppressive therapy with prednisone, azathioprine and cyclosporine was maintained. Pregnancy was complicated by an acute rejection episode on week 13, mild hypertension and intrahepatic cholestasis on week 22. Cesarean section and tubal ligation were performed at 32 and a half weeks. A 2020 g female infant was delivered, with Apgar scores of 8 and 9 at 1 and 5 min, respectively. Mild respiratory distress, jaundice and hypocalcemia were noted. The Australia antigen was negative. No fetal anomalies were detected. The high risk of pregnancy in a class T diabetic patient is confirmed in this case.

Acute Disease

A prospective one-year study evaluating the clinical outcome of recipients of living donor kidneys treated with cyclosporin and azathioprine.

Thirty recipients of living related donor kidneys treated either with cyclosporin or azathioprine were evaluated clinically and functionally in a 1-year prospective study. Only the azathioprine group showed either accelerated or chronic rejection (one patient each). The azathioprine patients had higher rate of infectious episodes (P = 0.05), leukopenia (P = 0.003) and steroidal side-effects (P less than 0.007). During the early post-transplant period the renal functional performance was the same in both groups. Afterwards, however, the plasma creatinine was higher in the cyclosporin group (P less than 0.01). Mean arterial pressure remained similar throughout the study in both groups. The anaemia correction was similar in both groups but the haematocrit was greater in the cyclosporin-treated subjects (P less than 0.005).

Adult

[Parasitic infections in renal transplantation patients].

We performed indirect hemagglutination tests for toxoplasmosis and Chagas disease, complement fixation test for toxoplasmosis, stool examination for parasites and Graham test for enteroparasites in 51 patients before and after renal transplant. Post transplant surveys were performed at 3, 6, 9, 12 and 18 months. 18 patients who were positive for toxoplasmosis remained so and 5 new asymptomatic cases were detected in the post transplant period (15%). Two patients who were positive for Chagas disease remained positive and asymptomatic. One patient receiving a kidney from a Chagas positive donor remains negative. Asymptomatic enteric infection was detected in 45% of patients at some time during follow up: amebic infection (25%), giardiasis (14%) and oxyuriasis (24%). Two patients showed asymptomatic cryptosporidiasis.

Chagas Disease