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Biomedical subjects

A Modica

Publications and source records attributed to A Modica.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

[Effect of prostaglandins on the cardiovascular system].

Ever since the effect of prostaglandins on vasal tone and cardiac function was discovered, an impressive series of studies has been conducted on their relations with the cardiovascular system. These studies have been extended to the prostaglandin system compounds discovered in more recent times. Of these, particular importance is being attached to prostacycline, though to be implicated in the physiological control of platelet clumping and also in that of renin secretion. Further investigation of the part played by prostacycline and other prostaglandins in cardiovascular disease has given unusually promising interim results.

Animals↗
PubMedDate not supplied

[The biological effects of the CO2 laser studied in experimental intestinal resections].

An histological and E.M. study has been performed on rat's intestinal tract resection to evaluate CO2 laser effects. Necrotic effect of laser is evident up to 120 micron. While the intestinal tissue results normal at 480 micron from resection line. Muscular and fibrous components appear more resistant to damage while E.M. presents a new organization of its components forming a new compact and continue tissue. This new organization may be involved in the protection of the subepithelial spaces, and may have an important role in intestinal anastomosis scar process.

Animals↗
PubMedDate not supplied

Nature and potential of the reactive response to mouse mammary adenocarcinoma cells engineered with interleukin-2, interleukin-4 or interferon-gamma genes.

A spontaneous mammary adenocarcinoma of BALB/c mice was transduced with the murine interleukin (IL)-2, IL-4, and interferon (IFN)-gamma genes. The ability of clones releasing IL-2, IL-4 or IFN-gamma to form tumors after s.c. challenge was compared to the TS/A parental cells (TS/A-pc) and to cells transduced with the neomycin resistance gene alone. Cytokine-gene-transduced clones activated a strong inflammatory reaction. The elicited by IL-2 and IL-4-gene-transduced cells efficiently led to tumor rejection. This reaction depended on the activation of several cell mechanisms, those classed as nonspecific being predominant. The repertoire of reactive leukocytes recruited in the reaction varies as a function of the secreted cytokine. The growth of a secondary contralateral TS/A-pc challenge after clone rejection was significantly impaired.

Adenocarcinoma↗