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Biomedical subjects

A Mohan

Publications and source records attributed to A Mohan.

87 records · Page 5Linked to original sources
PubMedDate not supplied

Effect of additional oral ofloxacin administration in the treatment of multidrug-resistant tuberculosis.

The effect of additional oral ofloxacin administration was evaluated in 19 HIV-negative patients with multidrug-resistant tuberculosis (MDR-TB). Their mean duration of illness was 3.6 years. Based on chest roentgenograms, 13 patients had advanced disease and 6 had moderate disease. In addition to 'second-line drugs', patients were treated with oral ofloxacin; high dose 800 mg per day (12 patients), low dose 400 mg per day (2 patients) and intermittent twice a week regimen of 800 mg a day (5 patients). With treatment, there was a significant clinical improvement. Sputum smear conversion occurred in 18 patients (mean duration 15 weeks) and this sputum smear negativity persisted for a mean duration of 7 months. Chest roentgenograms revealed regression of lesions in 18 patients. Reversible side effects were encountered in four patients. Results of present study suggest that additional administration of oral ofloxacin is both effective and safe for the treatment of MDR-TB.

Administration, Oral↗
PubMedDate not supplied

Acute respiratory distress syndrome (ARDS) in miliary tuberculosis: a twelve year experience.

Miliary tuberculosis [MTB] is an uncommon but important treatable cause of acute respiratory distress syndrome [ARDS]. In this communication, six patients with MTB who developed ARDS in the course of their illness are described. The difficulties encountered in diagnosing MTB as a primary cause of ARDS are highlighted. The pathogenetic mechanisms of ARDS in MTB are briefly reviewed.

Adolescent↗
PubMedDate not supplied

Pulmonary nocardiosis.

A case of pulmonary nocardiosis is described in a patient who had alcoholic cirrhosis of liver and portal hypertension. The patient also had diffuse proliferative glomerulonephritis and was on prednisolone treatment.

Anti-Bacterial Agents↗
PubMedDate not supplied

Peak expiratory flow rate in school-going children.

Peak expiratory flow rate (PEFR) was measured with mini Wright's peak flow meter in 783 children (aged 6-17 years) from a school in urban Delhi and 523 children (aged 6-15 years) from another school in Nellore, Andhra Pradesh. In all the children, age in completed years, sex, height, weight, chest circumference at full inspiration and maximum chest expansion were recorded. Age, sex, height and weight were independent predictors of PEFR in children from Nellore. Age, sex and height, were independent predictors of PEFR in boys from Delhi while height alone was an independent predictor of PEFR in Delhi girls. Common prediction equations for predicting PEFR in boys and girls have been developed for both regions based on age and height. For the same height and age, boys had higher PEFR than girls. In the females, the PEFR seemed to have a plateaux effect after the age of 14 years; such an effect was, however, not seen in the boys in the age range studied. The PEFRs of children from both parts of the country were similar, and were lower than those reported for American white children.

Adolescent↗
PubMedDate not supplied

Clinical presentation of tuberculosis in patients with AIDS: an Indian experience.

A retrospective series of 25 patients with AIDS and tuberculosis is presented. Their clinical presentation, absolute lymphocyte count, CD4+ and CD8+ lymphocyte counts, treatment details and outcome are detailed. Commonest method of acquiring HIV infection was through heterosexual contact (10 of the 25; 40%) and blood transfusion (10 of the 25; 40%). More than 50% of the patients (14 of the 25) had extrapulmonary tuberculosis. Eighteen of the 19 patients for whom values were available had CD4+ lymphocyte count < 200/mm3. Four of the 18 patients for whom follow-up details were available died.

AIDS-Related Opportunistic Infections↗