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Biomedical subjects

A Mohsen

Publications and source records attributed to A Mohsen.

14 recordsLinked to original sources
PubMed1997

Brucellosis in fish.

Brucellosis is a zoonotic infectious disease that represents serious economic and health problems. It has been extensively studied in different species of livestock but literary references to fish brucellosis are scarce. Therefore, the purpose of the research hereby presented was to investigate the serologic-bacteriologic response of Nile catfish to experimental infection with brucellosis. Thirty predatory catfishes were used. They were divided into two groups. The first was subjected to s. c. infection with Brucella melitensis biovar 3, the other to s. c. application of physiological solution. Three fishes from each group were killed once a week within 5 weeks to subject them to serologic-bacteriologic examinations. It was found that brucella antibodies were detected in the blood of infected fishes after 7 days post-inoculation. The antibody titre was maintained throughout the period of observation. The organism was also recovered from visceral organs of infected fishes. On the other hand, none of control fishes showed any serologic or bacteriologic response. These results suggest that fish could be considered as a suspectable species to brucellosis. Subsequently, further studies are needed to clarify the possible role of fish in the disease transmission.

Animals↗
PubMed1996

4',17-dioxo-5'H-estra-1(10),4-dieno[3,2-b]furan: synthesis, binding affinity to the estrogen receptor, uterotrophic and antiimplantation activities.

4',17-Dioxo-5'H-estra-1(10),4-dieno[3,2-b]furan (3) has been prepared by several routes starting from 2-bromoacetylestrone (2). Performance of the reaction with thiourea at elevated temperature provided compound 3 in good yield. When other reagents such as thiosemicarbazide, morpholine, sodium hydroxide or sodium hydride were treated with 2-bromoacetylestrone at room temperature, the furano derivative 3 was also obtained as the sole product. This new type of structural modification provided an estrogen nucleus deprived of the 3-hydroxyl function which was previously thought to be an essential requisite for binding to the estrogen receptor (ER). When evaluated in vitro for binding to the ER and in vivo for uterotrophic and antifertility activities, the furano derivative 3 was capable of inhibiting [3H]E2 binding by 16% while still eliciting high uterotrophic (99%) and postcoital antiimplantation (100%) activities relative to estradiol.

Animals↗
PubMed1992

Synthesis and evaluation for uterotrophic and antiimplantation activities of 2-substituted estradiol derivatives.

Two novel series of 2-substituted estradiol derivatives have been synthesized and evaluated for uterotrophic and antiimplantation activities. Among the compounds tested in the rat, 2-acetylestradiol 17 beta-acetate (1), 2-(3'-dimethylamino-1'-propionyl)estradiol 3,17 beta-diacetate (7), 2-(3'-diethylamino-1'-propionyl)estradiol 3,17 beta-diacetate (8), 2-(3'-piperidino-1'-propionyl)estradiol 3,17 beta-diacetate (9), 1'-(2-estradiol 3,17 beta-diacetate-3'-diethylaminopropionyl thiosemicarbazone (12), and 1'-(2-estradiol 3,17 beta-diacetate)-3'-morpholinopropionyl thiosemicarbazone (14) displayed estrogenic activity. At dosages of 4 microliters/rat/day, none of the tested compounds elicited antiimplantation activity. All compounds shared a similar characteristic: nuclear substitution at the C-2 position of the steroid nucleus, a property previously thought to be markedly inhibitory for estrogenic activity.

Animals↗
PubMed1990

Effect of Rift Valley fever virus on pregnant and non-pregnant local Barki ewes after artificial infection.

Studies were conducted into effects of Rift Valley fever virus on oestrous and vaginal cytology in non-pregnant ewes. 6 pregnant and 8 non-pregnant local Barki ewes were subcutaneously inoculated with different doses of virus isolated from Sharkia Province. Observed were irregularities in the oestrous cycle (20-28 days inoculation) and anoestrum. The anoestrum smears included large non-cornified epithelial cells with large well stains centrally located nuclei together with a large number of bacteria. Abortion and retention of placenta occurred in pregnant ewes with prolonged puerperal heat up to 70 days. Inoculation of virus was followed by thermal response. Re-isolation of virus in BHK cells was possible from aborted foetuses and placenta.

Abortion, Veterinary↗
PubMed1990

Synthesis of 3-aryl-2-substituted-4(3H)-quinazolines as potential antimicrobial agents.

Three new series of 4(3H)-quinazolinone derivatives were synthesized, namely: [3-Aryl-4(3H)-quinazolinon-2-yl]-methylenehydrazino-(N- substituted)-thiocarbamides, 3-Aryl-2-(3-substituted-4-phenyl-2,3-dihydrothiazol-2-ylidenehy drazonomethyl)-4 (3H)-quinazolinones and 3-Aryl-2-(3-substituted-4-oxothiazolidin-2-ylidenehydrazonometh yl)-4(3H)-quinazolinones. The antimicrobial activities of the synthesized compounds were also studied.

Anti-Bacterial Agents↗
PubMed1985

Novel thiazolidine-2,4-dione-4-thiosemicarbazone and 4-[(3,4-diaryl-3H-thiazol-2-yl)azo]thiazolidin-2-one derivatives: synthesis and evaluation for antimicrobial and anticancer properties.

Two novel series of 3-benzylthiazolidine-2,4-dione-4-thiosemicarbazones (V - IX) and 3-benzyl-4-[(3,4-diaryl-3H-thiazol-2-yl)azo]thiazolidin-2-on es (X - XXII) were synthesized as potential antimicrobial and anticancer agents. The products were found to be inactive against a variety of microorganisms and the preliminary antileukemic evaluation of some representative compounds against P 388 lymphocytic leukemia indicated insignificant activity.

Animals↗
PubMed1978

Steroidal derivatives. Part 1: some novel steroidal thiosemicarbazones. Their synthesis, anticancer and endocrinological activities.

The synthesis of several novel thiosemicarbazone derivatives of steroids, including estrogens and androgens, is described. Evaluation of the products in P 388 Lymphocytic Leukemia indicated no anticancer activity. The endocrinological screening showed that estrogenicity is slightly reduced but not abolished in the thiosemicarbazones derived from estrone-3-methyl ether (compounds 1, 2 and 4). The androgenic activity of the thiosemicarbazones derived from testosterone (compounds 7--9) was more pronounced than that of testosterone. Among the same thiosemicarbazone derivatives 7--9, only o-tolyl derivative 8 exhibited anabolic activity.

Animals↗
PubMed1975

Novel synthesis of 2-substituted aminobenzimidazoles from thiourea derivatives.

The use of different alkyl halides as effective cyclodesulfurizing agents was thoroughly studied. N-phenyl-,N'-[o-aminophenyl]-thiourea when treated with different alkyl halides gave rise to 2-phenyl-aminobenzimidazole. The optimum conditions for such cyclodesulfurization reaction were established by using eight equivalents of the alkyl halide, ethyl alcohol as solvent, and 8 h reflux. The reaction was also successfully applied to N-o-tolyl (benzyl or n-butyl)-N'-[o-aminophenyli1-thioureas to give rise to the corresponding 2-substituted aminobenzimidazoles.

Amines↗
PubMed1975

New facile synthesis of 2-substituted aminobenzimidazoles.

In this investigation, the cyclodesulphurization of N-o-aminophenyl-N'-phenylthiourea to produce 2-phenylaminobenzimidazole under the influence of dimethylsulphate was thoroughly studied under different reaction conditions. The mechanism of such reaction was also suggested.

Amines↗
PubMedDate not supplied

Bleeding from an epiphrenic oesophageal diverticulum.

A 49-year-old woman with a 2-month history of mild dysphagia and three episodes of haematemesis was found at endoscopy and barium swallow to have an epiphrenic oesophageal diverticulum containing an ulcerating crypt, but no ectopic gastric epithelium. Diverticulectomy and lower oesophageal myotomy gave a good result.

Adult↗