Severe hypotony following cataract extraction in a patient on latanoprost.
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Aged↗
Biomedical subjects
A Morrell
Publications and source records attributed to A Morrell.
Creating a hospital-based nursing research fellowship program for staff nurses.
Staff nurses are expected to participate in nursing research and to use study findings. Insufficient institutional support and uncertainties about how to participate in the research process can prevent staff nurses from meeting these expectations. We describe a newly developed nursing research fellowship program designed for staff nurses who practice in an acute care setting. An overview of the entire curriculum and the outcomes of the first year of the program are described.
Curriculum↗
Successful medical therapy of Acanthamoeba keratitis with topical chlorhexidine and propamidine.
INTRODUCTION: Following laboratory studies on new potential chemotherapy for Acanthamoeba keratitis, when chlorhexidine and propamidine provided an additive in vitro effect, a series of 12 patients with culture-proven Acanthamoeba keratitis from three UK centres was monitored during and after therapy. METHODS: In all cases the clinical diagnosis was confirmed by amoebal culture. In some instances identification of the protozoa by direct microscopy of corneal tissue was possible. The medication was provided topically in drop form until the keratitis had resolved. In vitro sensitivity to chlorhexidine and propamidine was performed on all isolates and compared with sensitivity to a range of other drugs used for treatment of the infection. RESULTS: In vitro drug testing confirmed that trophozoites and cysts of all 12 Acanthamoeba isolates were fully sensitive to chlorhexidine and propamidine. Therapy was satisfactory for controlling and eradicating the acanthamoebal infection in all patients. Three patients developed discrete stromal infiltration at the site of infection that resolved 1 week after commencing therapy, with or without use of steroids. Two patients developed a late inflammatory effect in the stromal scar at 6 months, which resolved with steroids. No clinical evidence of chlorhexidine toxicity was found in any patients. CONCLUSIONS: The combination of topical chlorhexidine and propamidine was very effective for treating Acanthamoeba keratitis provided the drugs were continued for a sufficient period. No drug toxicity or resistance of Acanthamoeba isolates was observed in the 12 treated patients.
Acanthamoeba↗
Ocular chromatic aberration and age.
The amount of longitudinal chromatic aberration in groups of younger and older subjects is compared in three separate studies, using a laser speckle optometer, Badal optometers with monochromatic illumination, and monochromatic retinoscopy. No evidence is found for any systematic change in chromatic aberration with age.
Adult↗
A bichromatic laser optometer.
A laser refractive technique involving the simultaneous viewing of red (633 nm) and green (514 nm) speckle patterns has been investigated. The speckle patterns are displayed on adjacent, contra-rotating drums with a common axis, the refractive status being determined by matching the apparent speckle speeds for the two wavelengths. The refractive corrections found are compared with those determined by making either red or green speckles appear stationary, and with the independently determined results of conventional subjective refractive procedures. It is concluded that, although the bichrome technique is feasible, most subjects found the conventional laser method, involving red speckles alone, easier to use and that the associated results were slightly more reproducible.
Adult↗