PubMed Health⌕ Search

Biomedical subjects

A Moulin

Publications and source records attributed to A Moulin.

5 recordsLinked to original sources
PubMed1979

[Pneumococcal capsular types of clinical specimens. Lyon: 1972-1977 and 1978 (author's transl)].

878 strains of Streptococcus pneumoniae were tested during two periods : 667 strains from 1972 to 1977 and 211 strains during 1978. Strains were isolated from spinal fluids, blood, peritoneal fluids, urines, exudate from respiratory tract except sputum. In polymicrobial specimens, only the predominant species were serotyped. From 1972 to 1977, 53,3% of strains are typed and 6 serotypes and pools are prevalent among 68,5% of typed strains, the most frequent are : 6 - D - 18 - 19. During the second period (1978) 82,5% of strains are typed, 9 serotypes are prevalent among 68,5% of typed strains, the most frequent are : 6 - 19 - 23 - 3. During 1978, 27,6% of strains are isolated from child wards, others from adults wards. A comparison of the relative frequencies of the serotypes in the two wards shows that the following 10 serotypes are the most frequent: 6 - 19 - 23 - 3 - 18 - 1 - 8 - 9 - 14 - 4.

Adult↗
PubMedDate not supplied

The surgical treatment of fractures of the upper end of the humerus by blind pinning (author's transl).

During a period of five years, the authors have treated 250 fractures of the upper end of the humerus. Fifty-one were treated by blind pinning. Six to eight Kirschner wires are passed up to the head of the humerus under X-ray control through a hole made on the posterior aspect of the lower end of the humerus just above the olecranon fossa. The functional results were satisfactory in 70% of cases. The indications for pinning were for severely displaced fractures, comminuted fractures, either impacted or not, or slipping of the upper humeral epiphysis. The results were less satisfactory in cases with an elevated greater tuberosity. The technique cannot be applied to fracture-dislocations.

Adolescent↗
PubMedDate not supplied

Structural and functional mapping of immunoglobulin V-regions.

V-regions of immunoglobulins chains contain 3 types of positions, which are equally represented: invariant and sub-group characteristic, which account for the "framework" and hypervariable positions, responsible for antigen recognition. The 3 types of positions are grouped and fall within a very few discrete stretches. Sub-group characteristic segments containing one of the 2 cysteyl residues of the V-regions may be isolated by high voltage paper electrophoresis and provide a basis to type for sub-groups in the VK and in the VH human systems. This allowed to characterize a large set of human myeloma proteins that were used in a series of competitive hybridizations which indicated that sub-groups had no influence on preferential reassociations, which occurred in 80% of the cases. This preference seems to rely mostly on individual structural differences, which may be linked to heterogeneity at the framework level. Distinction between framework heterogeneity and hypervariable regions heterogeneity may be approached by raising antibodies against a mouse myeloma protein, MOPC 173, of known sequence, by means of syngeneic and allogeneic immunizations, using Balb/c and A/J mice. Junction of distinct portions of immunoglobulin chains such as the V and the C regions raises the possibility that some recognition signals may operate at the DNA level. Since rotational symmetry regions in the DNA are known to act as such signals, it is discussed whether such regions can be expected from the amino acid sequence data, especially in the vicinity of the "switch" peptide.

Amino Acid Sequence↗