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Biomedical subjects

A Mounier-Kuhn

Publications and source records attributed to A Mounier-Kuhn.

At least 19 recordsLinked to original sources
PubMed1985

Althesin interaction with human plasma steroid binding globulins.

The binding affinities of two steroid anaesthetics, alphaxalone (Alfx) and alphadolone acetate (Alfd), for testosterone-oestradiol-binding globulin (TeBG) and corticosteroid-binding globulin (CBG) were measured in human serum. In 8 male patients, the effect of i.v. administration of Althesin (a mixture of Alfx and Alfd) on the transport of testosterone (T) and cortisol (F) was studied. Both Alfx and Alfd bind to TeBG and CBG with a relatively high affinity (10(6)M-1). A significant change in the percentage of unbound T was observed during Althesin infusion, with no change in total T concentration or in the TeBG binding parameters. The results suggest that by interaction with TeBG binding sites Alfx and/or Alfd displaced T bound to TeBG, and transiently increased the percentage of unbound T. A significant increase in the concentration of F was observed during althesin infusion, while the percentage of unbound F and the CBG binding parameters were unchanged. The dose of Alfx and Alfd used was not sufficient to alter the transport of F during brief althesin anaesthesia in men.

Adolescent↗
PubMed1976

[Treatment of respiratory distress caused by laryngeal obstruction].

Respiratory distress due to laryngeal obstruction produces a more or less dramatic syndrome depending on the cause of the obstruction and its evolution in time. Treatment should be immediate in order to avoid death or cerebral and cardiac sequelae. It consists, above all, of restoring the patency of the respiratory tract, the short-circuit obtained by intubation or tracheotomy should, in no case, leave any laryngeal sequelae. The authors present their personal series based on a study of respiratory distress due to laryngeal obstruction in the child. These observations were obtained from a large series of 480 cases of laryngeal dyspnea observed over the last 5 years on the E.N.T. unit of the Edouard Herriot Hospital in Lyons. They contrast a very small number of sub-glottic laryngitis cases requiring intubation or tracheotomy to a very large number of cases of subglottic laryngitis, even with respiratory distress, which recovered with well designed medical treatment. Foreign bodies, of which they report eleven cases, all required emergency surgery. They emphasize the severity of this cause. As far as papillomas and angiomas are concerned, they require emergency treatment, either straightaway or after a trial of medical treatment.

Adult↗
PubMed1976

[Emergency treatment of tracheal and bronchial foreign bodies].

Basing their report on personal experience of more than 300 tracheal or bronchial foreign bodies, the authors emphasize: -the difficulty of extraction, even in very expert hands. -the absolute necessity of a fully trained operator, and experienced anaesthetist and appropriate material. Apart from acute respiratory distress, they consider preferable to defer operation for a few hours, under strict supervision, in order to make available all these optimal conditions.

Anesthesia, General↗