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Biomedical subjects

A Moutet

Publications and source records attributed to A Moutet.

4 recordsLinked to original sources

[Management of 29 children with thyroid cancer following the Chernobyl accident].

As a consequence of the Chernobyl nuclear power plant accident, a considerable increase of thyroid cancer among contaminated children has been reported in Ukraine, Belarus and Russia. A group of 29 children aged from 5 months to 10 years (mean 4.7 years) at the time of the accident, with a papillary thyroid cancer, have been examined at the Pitié-Salpêtrière hospital in Paris. The cancer was discovered by systematic ultrasonography in only 25% of cases. No reliable dosimetric estimation was achieved. The initial surgical treatment was performed in Ukraine. Cervical lymph node and pulmonary metastases were present in 24 and 11 cases respectively. A complementary surgical treatment was necessary for 9 children and one to four radioiodine treatments were given to 24 children. With a mean delay of 7 years after the cancer discovery, an apparent cure or a remission was obtained for 20 children, 6 children have cervical lymph node metastases requiring a surgical treatment and 3 have evolving lung metastases. The management of the great number of foreseeable cases of thyroid cancer requires an improved systematic screening, a large number of rooms dedicated to high activity radioiodine treatments, funds for disposable material and training missions.

Child↗

Pregnancy in women with immune thrombocytopenic purpura.

Thirty-six women with immune thrombocytopenic purpura were studied during 37 pregnancies, and maternal characteristics with predictive value for the fetal platelet count were determined. Nine neonates were thrombocytopenic, with a platelet count of less than 50 x 10(9)/L in eight. Four of these nine neonates delivered to a subgroup of 31 mothers were studied prospectively; the frequency of thrombocytopenia in neonates of women with immune thrombocytopenic purpura was thus 13%. Only two of these nine neonates presented with hemorrhagic syndromes (two, petechial purpura; one, intracranial bleeding). The frequency of neonatal thrombocytopenia was higher in mothers with deep thrombocytopenia and in those who had not responded to corticosteroid treatment following diagnosis. No prognostic value could be assigned to the other maternal characteristics studied, such as a history of splenectomy, maternal treatment at the time of delivery, or the presence of platelet autoantibodies evaluated either with the platelet immunofluorescence test or the platelet Western blot immunoassay.

Autoantibodies↗

[Pulmonary aspergilloma appearing early].

A 62-year old smoker and alcoholic woman with chronic obstructive lung disease was admitted for suppurative pneumonia with cavitation and developed an intracavitary aspergilloma less than 2 months after the first signs of pneumonia. In view of the short time elapsed between the aspergilloma and the onset of suppurative pneumonia, 2 possibilities are discussed: either an aspergilloma developed unusually early in the cavity of a recent pulmonary abscess, or the patient had a chronic necrotizing pulmonary aspergillosis diagnosed at an early stage, which would account for all the manifestations observed.

Aspergillosis↗