Biomedical subjects

A Muñóz Villa

Publications and source records attributed to A Muñóz Villa.

3 recordsLinked to original sources

PubMed1980

[Wilms' tumor: a series of 79 cases (author's transl)].

79 cases of Wilms' tumor with age at diagnosis between 0 and eight years, are reported. 76 of them are evaluable for therapeutic results. 54 (71%) are alive and disease-free, with a mean survival of 53 months. Group A (35 patients) received pre-surgical treatment with radiotherapy and the survival rate is 77%. Group B (32 patients) were not treated before surgery and the survival rate is 84%. Both groups received post-surgical treatment with radiotherapy and chemotherapy (vincristine and actinomycin D). Patients in group C, chronologically the oldest, did not receive chemotherapy and its survival rate was 20%. Prognostical significance of age, sex, site, clinical stage and histology are examined. Classical concepts on histological classifications are revised and present criteria are shown, along with its' therapeutic and prognostic implications.

Child, Preschool↗

PubMedDate not supplied

[Long-term survival in childhood acute lymphocitic leukemia (author's transl)].

Long-term results in the treatment of 116 patients of acute lymphocitic leukemia with ages between six months and seven years are reported. A first group A, formed by 76 patients, was treated with prednisone and vincristine as induction protocol and maintenance therapy with 6-mercaptopurine or methotrexate. No neuromeningeal prophylaxis was made, except some cases in which intratecal methotrexate was applied. 27 patients are alive, 21 of them (27,6%) remain in complete remission for more than three years. A second group B, formed by 40 patients, was treated more recently; with an induction protocol composed by prednisone, vincristine and L-asparaginase. All patients in this group received cranial irradiation and intratecal methotrexate. 31 patients are alive (77,5%), 13 of them (32,5%) remain in complete remission for more than two years. The evolution period in this group B is shorter, but some features are exposed which suggest the possibility of long-term better results.

Asparaginase↗

PubMedDate not supplied

[Leukemia and hypercalcemia (author's transl)].

Two cases of childhood leukemia with hypercalcemia are reported. In the first case who died by acute granulocytic leukemia, autopsy showed a generalized calcinosis. The other case was an acute lymphocitic leukemia with hypercalcemia and destructive lessions of bones with pathologic fractures. Response to chemotherapy was good. Literature about mechanismes which can induce hypercalcemia in malignancy is reviewed.

Antineoplastic Agents↗