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Biomedical subjects

A Muchtar

Publications and source records attributed to A Muchtar.

4 recordsLinked to original sources
PubMed1990

Pharmacokinetic and pharmacodynamic properties of controlled release (CR/ZOK) metoprolol in healthy Oriental subjects: a comparison with conventional formulations of metoprolol and atenolol.

The steady state pharmacokinetics and pharmacodynamics of metoprolol controlled release tablets 100 mg CR/ZOK, was compared with those of metoprolol conventional tablets 100 mg (CT) and atenolol 50 mg (ATL) in ten healthy Oriental men. The study was of double-blind, cross-over placebo controlled design. The three study drugs and placebo were given in a random order once daily for 4 consecutive days with 1-week wash-out between each period. Treadmill exercise tests were performed and blood samples were obtained at fixed intervals after the fourth dose of each treatment. There was less fluctuation in the plasma level-time profile after CR/ZOK than CT and ATL. Plasma concentrations were significantly higher on CR/ZOK than CT at 24 hours after dosing. The relative bioavailability of CR/ZOK to CT was 69.0%. CR/ZOK achieved relatively more uniform beta-blocking effect over the dose interval. Compared to CT and ATL, the peak effect after CR/ZOK was less pronounced and the beta-blockade after 24 hours more effective.

Adult↗
PubMed1990

A dose-ranging study of phenylpropanolamine on nasal airflow.

A double-blind randomized placebo-controlled study comparing the effect of 2-dose levels of phenylpropanolamine (PPA) for acute rhinitis was performed in 180 outpatients. PPA was given in a fixed dose combination with paracetamol, chlorpheniramine and vitamin C. Two doses of each drug were given with a 4-h interval. Based on objective evaluation of nasal airflow using a Connell rhinometer, it was shown that PPA 25 mg was significantly more effective than the active placebo and PPA 15 mg. The decongestant effect of PPA 25 mg was markedly seen after 1 h, becoming maximal after 1.5 h, and was maintained for 2 h, after which the effect decreased until just before the second dose was given. The second dose gave a similar result as the first dose. PPA 15 mg was less effective and of shorter duration than the 25 mg dose, but gave sufficient improvement of nasal congestion.

Dose-Response Relationship, Drug↗