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Biomedical subjects

A Mundy

Publications and source records attributed to A Mundy.

6 recordsLinked to original sources

Hospital-acquired urinary tract infection.

Nosocomial urinary tract infections (UTIs) account for up to 40% of all hospital-acquired infections. The associated morbidity and mortality are a major drain on hospital resources. Patients with indwelling urinary catheters, patients undergoing urological manipulations, long-stay elderly male patients and patients with debilitating diseases are at high risk of developing nosocomial UTIs. The organisms responsible usually originate from patients' endogenous intestinal flora, but occasionally from a moist site in the hospital environment. Nosocomial pathogens causing UTIs tend to have a higher antibiotic resistance than simple UTIs. Infection control policies are important in limiting the number of hospital-acquired UTIs. Other important points include catheterisation using an aseptic technique and sterile equipment and the use of closed drainage systems. UTIs should be treated only after a urine sample has been sent and the advice of a microbiologist sought. In the future catheters impregnated with antibiotics, and the use of newer materials, may lead to further reductions in the incidence of nosocomial UTIs.

Anti-Bacterial Agents↗

[Artificial urinary sphincter].

OBJECTIVE: To review the literature on artificial urinary sphincters, to describe their function, technique of implantation, indications, results and complications, and to analyze the possible utility of the prosthesis in the treatment of stress incontinence. METHODS: Medline (Index Medicus Online) and Embase (Excerpta Medica Online) were accessed to review the literature on artificial urinary sphincters published from 1974 (when the first artificial urinary sphincter was described by Foley) to October 1999. Of 322 articles identified, only those that described the patient selection criteria, type of prosthesis utilized, results and complications, and mean follow-up were considered. Articles describing historical aspects and new prototypes were also reviewed. Papers by the authors of the present article were excluded to avoid the bias of author preference. The bias of the language barrier, which occurs when articles published in Spanish, English and French are reviewed, was minimum. RESULTS: The AMS-800 is the only model available today. The results achieved are excellent if the indication is correct and perioperative management is careful and exact. The ideal candidate is one with genuine stress urinary incontinence and normal bladder function, although hyper or hyporeflexia is not an absolute contraindication if corrected before, during or after insertion of the prosthesis. The surgical technique is relatively simple and the only difficulty consists in the choice of the appropriate cuff and reservoir. The complications include urethral atrophy, erosion, infection and bladder instability, and are less frequent in women with stress urinary incontinence type III and in men incontinent after prostate surgery, and more frequent in patients with incontinence following pelvic trauma, incontinence due to congenital malformation and those with a neurogenic bladder. The mechanical failures of the prosthesis have diminished with its improved design. New hydraulic and non-hydraulic prototypes have been designed to reduce the complications, but the results are as yet unavailable. CONCLUSIONS: Today, patients with stress urinary incontinence have more possibilities to recover continence. If incontinence persists after all the available medical and surgical options have been attempted, one possibility still remains: the artificial urinary sphincter.

Female↗

Dynamic multi-planar EPI of the urinary bladder during voiding with simultaneous detrusor pressure measurement.

Magnetic resonance imaging gives high quality images of the urinary bladder with excellent contrast. We report here the first application of dynamic, multi-slice, echo planar imaging to a study of urinary bladder emptying. Changes in urinary bladder volumes and rates of urine expulsion from the bladder have been measured simultaneously with bladder pressure. The method shows promise for clinical applications involving compromised bladder function, for reappraising bladder contraction strength-volume relationships, and for investigating the rate of change of length, three-dimensional shape, and wall tension in different parts of the bladder during micturition.

Echo-Planar Imaging↗