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Biomedical subjects

A N Boĭko

Publications and source records attributed to A N Boĭko.

At least 19 recordsLinked to original sources
PubMed1993

[The characteristics of the immune status of patients with Alzheimer's disease].

Disorders seen in patients with Alzheimer's disease are also related to the pathology of immunity. In order to study it in a more detailed manner, some immunity parameters were examined in 30 patients with Alzheimer's disease, 15 patients with Huntington's chorea which may have similar mechanisms of immunologic defects, and 15 healthy donors. A study was also made of the capacity of peripheral blood lymphocytes to respond to polyclonal mitogens in blast transformation test and according to the production of immunoglobulins in vitro. The subpopulation composition of these cells was investigated as well. A significant rise of the count of C 8+ lymphocytes, depression of proliferative response, low spontaneous and high Phytolacca mitogen-stimulated immunoglobulin production have been revealed. The changes recorded in Huntington's chorea had the same nature of development. The disorders revealed allow a conclusion about an important role that may be played by the immune system in these degenerative diseases of the brain.

Alzheimer Disease↗
PubMed1992

[Clinico-immunological monitoring of the condition of patients with multiple sclerosis].

The clinico-immunologic monitoring of 50 patients suffering from genuine multiple sclerosis by means of the clinical, neurophysiological and immunologic methods and NMR tomography attests to the relationship between changes in the clinical and immunologic characteristics. The changes in the immunologic characteristics were found to anticipate the clinical ones. The authors provide evidence for the possibility and necessity of the clinico-immunologic monitoring of the patients' status for predicting the further course of the disease.

Acoustic Stimulation↗
PubMed1992

[Results of clinico-immunological testing of myelopid in chronic forms of multiple sclerosis].

Forty patients with a verified diagnosis of multiple sclerosis (MS), the majority of whom had the secondary progressive form of the disease, received a short-term treatment with myelopid (MP). After this 10 patients were given a long-term treatment with MP. The clinical trial was carried out by the double blind method using placebo. The patients' status was estimated by special evaluation scales (clinical), immunoassays (the content of T lymphocyte subpopulations, reaction of blast transformation of leukocytes to mitogens under different conditions of cultivation including that in the presence of 0.3 micrograms/ml MP, by assessment of the production and activity of interleukin-2), by the method of evoked potentials and NMR tomography. 60% of the patients manifested an improvement of the clinical status after the short-term MP treatment, which was accompanied by positive dynamics of evoked potentials and a decrease of the functional activity of the cells in the reaction of blast transformation of leukocytes. In such patients, MS ran a more favourable course during 0.5-1.5 years of observation. In 8 patients with the immunologic signs of the pathological process activation, the clinical status worsened after MP. The correlation and regression analyses allowed one to specify the clinico-immunologic indications and contraindications for MP administration. The clinico-immunologic changes noted were not recorded after placebo. In the patients receiving the long-term treatment, one could see a further decline of the functional activity of the cells in the reaction of blast transformation of leukocytes, a rise of the content of T suppressors/killers in the blood, a favourable clinical course of MS.(ABSTRACT TRUNCATED AT 250 WORDS)

Activins↗
PubMed1990

[Characteristics of the set-up of the lymphocyte blast transformation reaction using whole blood].

The authors analyze the specific features of the technique of lymphocyte blastogenesis test (LBGT) with whole blood and of interpreting its results in examinations of healthy donors, patients with hypogammaglobulinemia, chronic bronchitis or pneumonia, and bronchial asthma. The suggested LBGT variant is a sensitive and reproducible technique fit for assessing the immunity status, making use of small volumes (up to 0.1 ml) of the blood; it is recommended for clinical examinations and mass immunologic screenings.

Adult↗
PubMed1990

[Study of cellular immunity and the opioid peptide system in patients with multiple sclerosis].

Twenty-five patients with chronic progressing multiple sclerosis were examined for the content of beta-endorphin in blood serum, supernatants of activated lymphocytes and CSF by RIA. At the same time the parameters of cellular immunity were appraised. Different relations were discovered between cellular immunity and the content of beta-endorphin in biological fluids which may play a material part in the pathogenesis of multiple sclerosis.

Adult↗
PubMed1990

[Diagnosis and surgical treatment of recurrent goiter].

Operations were conducted on 1,055 patients with postoperative recurrent goiter, in 211 of them the disease had recurred repeatedly. Thyrotoxicosis was diagnosed in 331 and nontoxic adenomatous goiter in 724 patients. Autoimmune thyroiditis was revealed in 77 of 237 patients with an autoimmune process in the thyroid gland. Carcinoma of the thyroid was recognised in 68 cases. The authors show the necessity for complex clinical, anamnestic, laboratory, radioisotope, ultrasonic, radiological, and aspiration cytologic examinations. An operation is indicated in severe thyrotoxicosis and all forms of adenomatous goiter. It is technically difficult to perform an operation for a second time. Those performed for adenomatous forms of goiter must be accompanied by an emergency histologic examination. Two methods for repeated operations are described. Correcting hormonotherapy after reoperations is a practicable means for preventing repeated recurrences. Quite favourable late results of surgical treatment are shown.

Adolescent↗
PubMed1989

[Characteristics of cellular immunity in multiple sclerosis].

In 30 patients with definite multiple sclerosis a combined clinicoimmunological investigation was performed. The results of estimation of T-lymphocyte subpopulations by means of flow cytometry and monoclonal antibodies; of proliferative responses to PHA, PWM and Con A, to PHA with autoserum; of synthesis and reception of IL-2 containing material is discussed. A hypothesis of a cyclic course of the immunopathologic process is suggested (autoimmune and immunodeficiency stages).

Adult↗