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Biomedical subjects

A N Bogdanov

Publications and source records attributed to A N Bogdanov.

At least 19 recordsLinked to original sources

Spontaneous skyrmion ground states in magnetic metals.

Since the 1950s, Heisenberg and others have addressed the problem of how to explain the appearance of countable particles in continuous fields. Stable localized field configurations were searched for an ingredient for a general field theory of elementary particles, but the majority of nonlinear field models were unable to predict them. As an exception, Skyrme succeeded in describing nuclear particles as localized states, so-called 'skyrmions'. Skyrmions are a characteristic of nonlinear continuum models ranging from microscopic to cosmological scales. Skyrmionic states have been found under non-equilibrium conditions, or when stabilized by external fields or the proliferation of topological defects. Examples are Turing patterns in classical liquids, spin textures in quantum Hall magnets, or the blue phases in liquid crystals. However, it has generally been assumed that skyrmions cannot form spontaneous ground states, such as ferromagnetic or antiferromagnetic order, in magnetic materials. Here, we show theoretically that this assumption is wrong and that skyrmion textures may form spontaneously in condensed-matter systems with chiral interactions without the assistance of external fields or the proliferation of defects. We show this within a phenomenological continuum model based on a few material-specific parameters that can be determined experimentally. Our model has a condition not considered before: we allow for softened amplitude variations of the magnetization, characteristic of, for instance, metallic magnets. Our model implies that spontaneous skyrmion lattice ground states may exist generally in a large number of materials, notably at surfaces and in thin films, as well as in bulk compounds, where a lack of space inversion symmetry leads to chiral interactions.

Journal Article↗

Skyrmions in nematic liquid crystals.

Analytical solutions for static two-dimensional axisymmetric localized states minimizing the Frank free energy for nematic liquid crystals have been derived. These solitonic structures (skyrmions) include the well-known Belavin-Polyakov solutions as a special case for equal elastic constants. The structure and the equilibrium parameters of these nematic skyrmions crucially depend on values of the elastic constants. Stability limits of these structures and the possibility to observe them in nematic liquid crystals are discussed.

Journal Article↗

Chiral symmetry breaking in magnetic thin films and multilayers.

A phenomenological theory of chiral symmetry breaking in magnetic nanostructures is developed considering induced, inhomogeneous chiral interactions (Dzyaloshinsky-Moriya-type). Application of the theory to films and multilayers with in-plane and out-of-plane magnetization predicts modulated and two-dimensional localized patterns (vortices). These new classes of magnetic patterns are intrinsically stable and localized on nanometer scale. Various experimental observations agree qualitatively with structures derived from this theory.

Journal Article↗

[Electro-impulse therapy in combined treatment of patients with thyrotoxic goiter complicated by cardiac fibrillation].

Cardiac fibrillation was revealed at admission in 260 (5.2%) of 4996 patients who were to undergo subtotal resection of thyroid gland for toxic goiter. In 114 (43.8%) patients sinus rhythm was restored with drugs in preoperative period. Electroimpulse therapy was carried out in other 146 patients which was effective in 89% cases. Efficacy of electroimpulse therapy depended mainly on the arrhythmia duration. Restoration of sinus rhythm before operation in patients with toxic goiter improves conditions of preoperative preparation and decreases the risk of surgical treatment. There were no lethal outcomes.

Adult↗

[The clinico-morphological characteristics of malignant non-Hodgkin's lymphomas].

It was established that most patients with non-Hodgkin malignant lymphomas against the background of secondary immunodeficiency show an activation of the saprophytic bacterial and mycotic flora that results in the development of different infectious complications essentially, thus, influencing the course and prognosis of the disease. A dependence was established between the malignancy grade of non-Hodgkins lymphomas and frequency of development of non-infectious complications.

Adult↗

[Secondary pneumonia in subjects with acute leukemia].

UNLABELLED: Of 105 patients with acute leukoses secondary pneumonias were found in 47.6%. A dependence was found of the frequency of pneumonia on the severity of initial hyperleukocytosis and duration of post-cytostatic agranulocytosis. The efficiency of routine criteria of diagnosis was 66% and increased significantly in microbiological and cytological investigation of the bronchoalveolar lavage fluid. TREATMENT: combined antibacterial therapy, antifungal, desintoxicating agents; in severe cases--endobronchial administration of monogroup leucocytic mass.

Acute Disease↗

[Comparative clinical characteristics of ischemic stroke with reversible and stable neurological deficit].

Fifty-four patients with minor and 54 with complete brain stroke were examined for the effect of the patients' age, nature of the underlying disease, its course, acuity of development, initial intensity, and successive dynamics of focal symptoms on the course of brain stroke. It has been discovered that the patients' sex or age, or the nature of the underlying disease do not produce any effect on the development of minor or complete brain stroke. The tendency towards decrease of the intensity of focal symptoms within the first 24 hours since the disease onset and early hospitalization of the patients was of paramount importance in cases with a complete regression of focal symptoms. The highest percentage of minor brain strokes was recorded if the patients were hospitalized within 12 hours since the disease manifestation.

Adult↗

[Epidemiology and risk factors of ischemic stroke in the Middle Ob region].

Based on the methods of the Brain Stroke Register, a study was made of epidemiology and risk factors (RF) of ischemic brain stroke (IBS) in one of the cities of the Middle Ob region, numbering 220 thousand population. Based on 615 cases of IBS, a noticeable rise of the disease incidence was revealed in a group of subjects aged 40-49 years as was a high level of the morbidity and mortality among persons over 60 years. Studies into RF discovered a high portion of arterial hypertension (75.1%), atherosclerosis (44.3%), aggravated heredity (28.6%), coronary heart disease (27.9%), alcohol abuse (17.9%). In 90.8% of cases, IBS developed in the presence of unfavorable fluctuations in atmospheric pressure, relative humidity, temperature, and the rate of air movement.

Adult↗

[Vertebrobasilar stroke].

As many as 112 residents of a town in the North of the Tyumen region were examined for the clinical course of vertebral basilar stroke (VBS). The latter ones occurred in 22.9% of patients with ischemic stroke, treated at the neurological hospital. The age of 66% of patients did not exceed 60 years. In 40% of cases, VBS developed within the first 5 years of the living in the Tyumen region and were dependent to a definite measure on the regional meteofactors.

Adult↗

[Receptor characteristics of the duodenal mucosa in peptic ulcer: a new approach to the individual selection of the therapy].

The radioligand-receptor method was used to assay the M-cholinereceptors and opioid binding centers in biopsy specimens of the duodenal mucosa from 40 patients with duodenal ulcer as compared with the results of subsequent therapy by means of gastrocepin (20 patients) and dalargin (20 patients). Analysis of the isothermal curve of 3H-QNB-binding with duodenal mucosa membranes within Skatchard's coordinates showed the presence of 2 subtypes of muscarinic receptors blocked (M1) and not blocked (M2) by gastrocepin. The majority of the patients in both groups demonstrated a significant decrease of the dissociation constant as compared to the control (20 patients). In patients with high receptor sensitivity to gastrocepin and dalargin, ulcer cicatrization was noted during the treatment in all the cases. Meanwhile the treatment proved little effective in patients with appreciably decreased receptor sensitivity to the drugs under consideration. The data obtained indicate the possibility of predicting the results of duodenal ulcer treatment by means of the radioreceptor analysis, providing the basis for the individualized treatment choice.

Adolescent↗

[Experience with the treatment of duodenal ulcer using H2-histamine receptor blockers].

The authors compared the efficacy of the blockers of H2-histamine receptors with the conventional multimodality treatment in patients with peptic ulcer of the duodenum and explored the effect of cimetidine on the secretory and motor functions of the stomach and on the endocrine status of the patients. It was established that cimetidine made the healing of duodenal ulcers more rapid as compared with the use of the multimodality therapy. It was also found that the drug efficacy was mainly related to the suppression of hydrochloric acid secretion in the stomach and to the recovery of motor activity of the stomach and duodenum. It is demonstrated that cimetidine has a broad-range action on the endocrine system, which should be taken into consideration in administering cimetidine.

Adolescent↗