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Biomedical subjects

A N Britov

Publications and source records attributed to A N Britov.

At least 19 recordsLinked to original sources
PubMed1992

[Testing of arterial hypertension with physical exercise PWCx ].

The relation of physical fitness (PF) to blood pressure (BP) and arterial hypertension risk factors was studied in a representative sample by PWCX exercise testing. The relations were studied at the initial stage, during exercise and recovery by using the multivariance stepwise regression analysis. This complex approach allowed the independent relation of PF to BP to be found. In normotensive males, systolic BP determined 4% PF variability after the first exercise, while in hypertensive males, the second exercise heart rate and age determined 27 and 9% PF variability, respectively. In normotensive females, the first exercise heart rate determined 62% PF variability, in hypertensive females, the second exercise systolic BP and age determined 4 and 2% PF variability, respectively. The value x shows the relation of PF to heart rate and BP in the restorative period and is an additional significant parameter of PF and the functional status of the cardiovascular system.

Adult↗
PubMed1992

[Relationship of physical work capacity, blood pressure and other hypertension risk factors with the rate of erythrocyte Na/Li countertransport].

The relationship of physical working capacity (PWC), blood pressure and other arterial hypertension risk factors to the rate of red blood cell Na+/Li+ countertransport was examined in a representative sample comprising 60 individuals (22 males and 38 females) whose age was 35-54 years. Regression analyses demonstrated that there was no significant relationship between PWC and the rate of red blood cell Na+/Li+ countertransport, but a significant correlation was found between the rate of Na+/Li+ countertransport and "double product" (DP) as an indirect indicator of PWC and heart rate. Thus, there is a heart rate- and DP-mediated correlation between the rate of red blood cell Na+/Li+ countertransport and the level of PWC. The magnitude of a decrease in the rate of red blood cell Na+/Li+ countertransport depends inversely on the dynamics of heart rate in males and females and directly on the dynamics of DP in females. Hence, there is a direct relationship between the magnitude of a reduction in the rate of red blood cell Na+/Li+ countertransport and that of PWC increment during exercise.

Adult↗
PubMed1992

[The results of conducting a program for the supplementary education of medical workers in the problems of preventing and treating arterial hypertension (a population study)].

A programme on supplementary health education of medical staff from city polyclinics in the prevention and treatment of arterial hypertension was launched in one of the Moscow districts for 3 years. Another district was used as a comparison subject. Representative samples of residents aged 35-64 years from the two districts were screened before and after implementation of the programme. The WHO International MONICA programme was used to evaluate the efficiency of the programme proposed by the authors. The intervention district showed an improvement of hypertensives' awareness of the disease and a double increase in the number of patients with a high compliance. In the comparison district, these parameters remained unchanged. According to the criteria developed in the MONICA programme, there was a downward tendency in the incidence of myocardial infarction and stroke and these diseases-related deaths in the intervention district, whereas this was not observed in the district under comparison.

Adult↗
PubMed1992

[Physical activity and physical work capacity of patients with initial manifestations of cerebrovascular disorders in arterial hypertension].

The routine protocol of general and neurological examinations and some special questionnaires were used to examine physical activity (FA) and physical working capacity (FWC) in a random population from one of the Moscow districts which included 1200 persons (males and females aged 30-64 years). The majority of the examinees were those who had slight and moderate exercises, mainly sitting work, did few or no physical exercises. The proportion of persons with low physical activity increased with age both among males and females. The ratios generally remained despite the presence of early signs of abnormal blood supply. Bicycle ergometer testings showed a significant reduction in the physical working capacity of the patients with abnormal brain blood supply, in a greater extent, in arterial hypertension. Decreased functional activity and functional working capacity may regarded as one of the risk factors for cerebrovascular disorders, in arterial hypertension in particular, and should be borne in mind in implementing preventive measures.

Adult↗
PubMed1991

[Blood pressure changes induced by various exercise regimes in patients with "mild" arterial hypertension].

How two regimes of exercise training affect blood pressure changes was examined in 70 individuals with mild arterial hypertension. Prolonged controlled exercise training were shown to be an effective tool of non-drug correction of elevated blood pressure, the exercises aimed at developing aerobic tolerance being more beneficial. The magnitude of changes (increase) of working capacity may be an indicator for the effectiveness of exercise training programmes.

Adult↗
PubMed1991

[The results of using pseudoplasmapheresis in bronchial asthma (a preliminary report)].

The authors provide the results of the treatment of 15 patients with infectious bronchial asthma by plasmapheresis (PA). All the patients received PA in accordance with the techniques developed by the authors. These techniques simulate standard procedures using a plasticized container and a refrigerator centrifuge. As a result of the studies carried out, it has been concluded that the clinical efficacy of false PA is similar to that of routine PA as regards the clinical manifestations of bronchial asthma. Apparently, the elimination effect and the effect of red blood cells plasma withdrawal are of no material importance in the mechanism by which PA influences bronchial asthma. The psychosomatic causes, effects of temporary blood loss, blood contact with polymeric materials, and the influence of temporary blood cooling may be under discussion.

Adult↗
PubMed1991

[Erythrocyte Na+/Li+ countertransport and arterial hypertension: data of a cross-sectional population study].

The relation of red blood cell Na+/Li+ countertransport rate to the prevalence of arterial hypertension (AH) and blood pressure was evaluated in 720 individuals aged 23-60 years. In all age groups, the rate of red blood cell Na+/Li+ countertransport was significantly higher in males than in females. Age, alcohol use, obesity in males and age, obesity, and Na+/Li+ countertransport rate in females are factors that predispose to AH, as evidenced by multivariate logistic analysis. The latter parameter is associated with obesity and diastolic blood pressure and unassociated with age, alcohol use, and smoke, as suggested by regression analysis. The distribution of Na+/Li+ countertransport rate values in the population after standardization for ruling out the impact of obesity is erroneous and shifted to the right. This allows it to be presented as a sum of two normal distributions. However, their analysis has failed to reveal statistically significant differences in blood pressure values of AH incidence. The rate of Na+/Li+ countertransport may be regarded as a biological population risk factor for AH, which is, however, less than such factors as age, obesity, and excessive alcohol use.

Adult↗
PubMed1991

[The role of the rate of sodium-lithium countertransport of the erythrocytes in arterial hypertension].

The present work is concerned with the role of the velocity of Na+/Li(+)-countertransport of red blood cells (as an indicator of the function of cellular membranes) in the development of arterial hypertension under conditions of a populational study. A relationship is demonstrated between the velocity of Na+/Li(+)-countertransport and the sex, arterial pressure, body mass index, and blood serum triglycerides. The high velocity of Na+/Li(+)-countertransport is encountered in 25% of the population, being responsible for about 30% of all cases of arterial hypertension. Taking into consideration the modern multifactorial theory of the genesis of arterial hypertension, the high velocity of Na+/Li(+)-countertransport should be viewed as a definite disease pattern (one of several) and as a risk factor of arterial hypertension in women (the data of the prospective part of the study).

Adult↗
PubMed1991

[The effect of different physical training regimens on the dynamics of arterial pressure and physical work capacity in persons with "mild" arterial hypertension].

The influence of three different modes of physical training (PT) on high arterial pressure was estimated in persons suffering from "mild" arterial hypertension. 154 men and women aged 35-54 years were entered into the study. In accordance with two different methods of estimating the initial physical work fitness (PWF), the test subjects were distributed into 4 groups. In these groups, the percentage of aerobic training aimed at the development of stamina was progressively raised. The dynamics of the initial PWF served as a criterion for the efficacy of PT. It has been demonstrated that firstly, both methods of estimating PWF are suitable enough for characterization of the dynamics of PWF, secondly, the decrease of arterial pressure is directly dependent on the effectiveness of the PT programs reflecting the dynamics of PWF, and, thirdly, PT aimed at the development of the general (aerobic) stamina is the most effective nonmedicamentous approach to the reduction of arterial hypertension.

Adult↗
PubMed1991

[Evaluation of the effectiveness of the program of primary prevention of arterial hypertension at an industrial plant based on a prospective epidemiological study].

Whether the primary arterial hypertension prevention programme can be applied among employees of a Novosibirsk industrial enterprise within the framework of the second stage of the USSR Cooperative Study of Arterial Hypertension Control, is studied. For this, the authors used sodium-restricted diet concurrent with non-drug therapy (physio-, balneo-, reflexotherapy and acupuncture), and active sanitary education. The 2-year prospective follow-up showed a sufficiently high efficiency of health measures: the incidence of borderline hypertension was reduced by 10.5% at the end of the study, blood pressures could be maintained at the level of the borderline and subnormal values in most patients with persistent hypertension, the patients at risk developed no persistent hypertension, cases. In a 20% blind sample from the matched population, the changes in the frequency of various blood pressures were insignificant during this period.

Adult↗
PubMed1991

[Erythrocyte sodium-lithium countertransporter level as a risk factor of hypertension (prospective study data)].

A 3-year prospective study was undertaken to evaluate the relation of red blood cell Na+/Li+ countertransport rates to the incidence of arterial hypertension. A total of 227 subjects (males and females aged 24-54 years)--a 20% representative sample of organized population--was followed up. The annual incidence of arterial hypertension was 4.3 among males and 2.7 among females. The baseline blood pressures and obesity in males and rates of Na+/Li+ countertransport in females were demonstrated to be factors associated with the incidence of arterial hypertension. The rate of red blood cell Na+/Li+ countertransport can be regarded as an independent biological risk factor for arterial hypertension.

Adult↗
PubMed1990

[Incidence of alcohol drinking and the structure of causes of death in men 40-54 years of age].

A total of 5,555 workers from 6 industrial enterprises in Cheboksary were screened. The most prevalent cause of death appeared to be violent death which encompassed deaths caused by accidents, poisonings, injuries, suicides and comprised 35.4 percent of the overall pattern of mortality causes. In 76.8 percent of cases violent death was caused by alcohol abuse. Deaths from alcohol poisoning during a 9-year period comprised 11.3 percent of total causes of death. The second place by prevalence was given to ischemic heart disease, including sudden coronary death (20.9%) and moreover almost in each case death was developing as a result of alcohol abuse. In 1986 after the adoption of the Decree of the Central Committee of the CPSU in May 1985 "On the measures to combat heavy drinking and alcoholism", the incidence of violent deaths caused by alcohol abuse, as compared with midyear rates for previous 8 years decreased by 4.7 times (p less than 0.01) which contributed to the development of a marked trend towards the decline in general mortality rates by 31.4 percent. The results obtained showed that despite certain shortcomings, measures targeted to combat heavy drinking and alcohol abuse promoted the prevention of death among men of productive age.

Adult↗
PubMed1990

Results of an epidemiological study of the prevalence of arterial hypertension among employees of selected plants in Moscow and Plzen. A cooperative study.

The quality of medical care provided especially to patients with arterial hypertension employed in three industrial plants (ZIL Automobile Works, Moscow, Mytishchi Machine Works, and Skoda Works, Plzen, Czechoslovakia) was investigated in random samples of male and female employees aged 35-64 years. The lowest prevalence of hypertension (AH) was found in Skoda Works (26.4 +/- 1.3%). A standardized cooperative epidemiological study detected a low percentage of treated AH cases and insufficient efficacy of treatment in all three plants, especially among young male hypertensives. The epidemiological status of AH in the ZIL and Mytishchi Works was less favourable compared with that in Skoda Works. Epidemiological data represent an indispensable basis for developing a scientific approach to primary and secondary prevention of AH.

Adult↗
PubMed1990

[The relation of arterial pressure and the rate of Na-Li countertransport in a representative subsample of the population of Moscow residents].

A study was made of the relationship between Na-Li countertransport and arterial blood pressure in 95 persons selected at random from the representative sample (n = 1716) of the population of one of the districts of Moscow. Of these, 34 persons turned out to be normotensive, 15 had borderline hypertension, 44 stable essential hypertension, and 2 persons presented with secondary hypertension. A positive correlation was found between countertransport and age and weight, determining 20.4% of interindividual variability of countertransport values. The mean value of countertransport in the hypertension group appeared much higher than in the normotensive group, both without and with regard to the correlating parameters. Repeated examinations demonstrated that the countertransport value in each person remained unchanged for two years. A nonlinear correlation was discovered between countertransport and arterial blood pressure. The rate of countertransport is not related to arterial blood pressure (low and high values). A dramatic change in the countertransport values occurred within a narrow borderline range of arterial blood pressure.

Biological Transport↗
PubMed1989

[Effectiveness of anti-alcoholism propaganda in preventing hypertension].

Questionnaire survey of 934 residents of various regions of the European part of the USSR and the results of the experimental impact of health education media under polyclinical conditions showed that awareness of alcohol-related risk could be achieved only due to doctor's assistance.

Adolescent↗
PubMed1989

[A new approach to evaluating the prevalence of electro- cardiographic high-amplitude R and S waves during mass screening].

Relationships between the prevalence of electrocardiographic high-amplitude R and S waves, the stroke index, mean hemodynamic arterial BP and left-ventricular myocardial thickness (MT) were examined in a population of 411 individuals, aged 35-64 years. The prevalence of those waves is shown to have independent functional relationships with the stroke index and mean hemodynamic BP, irrespective of left-ventricular myocardial morphology. This functional approach is used to explain the causes of low sensitivity of electrocardiographic signs of left-ventricular myocardial hypertrophy when used for diagnostic purposes at population screenings.

Adult↗
PubMed1989

[Methodological problems of evaluation of electrolyte intake in the clinical and population studies].

The paper deals with methodological problems of electrolyte intake in clinical and population-based studies. Marked inter- and intraindividual fluctuations were found to substantially affect the reliability of assessing the intake of electrolytes, which should be borne in mind in practice. Specifically, individual-based reliable characteristics of electrolyte intake (excretion) may be obtained after examining at least 8 daily urinary collections. The adequate validity of group electrolyte intake may be attained when a group consists of at least 8 persons. It is shown that it is feasible to employ the definite urine amounts to gain an insight into electrolyte intake.

Adult↗