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Biomedical subjects

A N Cheredeev

Publications and source records attributed to A N Cheredeev.

At least 19 recordsLinked to original sources
PubMed1999

[Immunological prognosis of the effectiveness of soybean diet].

During 50 days a group of 23 volunteers received lunches prepared on the basis of textured proteins of soy beans. Each lunch included 50 g of proteins. Laboratory investigation was carried on dynamic values of lipid metabolism, cell-mediated, humoral and local immunity. A total of more than 30 tests were made. The analysis of immunological reactivity in volunteers has revealed the immunomodulatory activity of soy bean protein similar to the reference modulator with known quantitative estimation of effects on cell mediated, humoral and local immunity. Statistic analysis of preliminary individual laboratory results and plotting of prognostic curves allowed to develop an original method of volunteer selection for whom soy bean diet may bring positive or negative results.

Adjuvants, Immunologic↗
PubMed1991

[The interpretation of laboratory parameters in evaluating the immune status of man].

At least 3 physiologic parameters appear to be useful for the assessment of the immunity status of a patient. These parameters are as follows: immunocyte ability to activation, proliferation, and differentiation; these characteristics may be directly examined with the use of novel products of immunobiotechnology. The suggested approach essentially simplifies interpretation of the findings obtained in studies of human immunity system. Besides lymphocytes, special attention is paid to immunoregulatory monocytes, macrophages, and granulocytes. Since these cells are known to secrete quite a number of mediators, an imbalance of their production and reception may contribute to the pathogenesis of many a disease.

Humans↗
PubMed1989

[T-lymphocyte induced normalization of transformed malignant fibroblasts: lymphokine with normalization factor activity].

Normalizing influence of different lymphocyte populations and their soluble factors on L-929 transformed malignant fibroblasts (L cells) has been examined. It was demonstrated that splenic T-lymphocytes caused stable (heritable) normalization of receptor apparatus, biophysical and proliferative characteristics of L cells. Lymphokine with the activity of normalization factor (NF) was purified from 24-hour immunocyte conditioned medium. Stability of the normalization phenomenon was caused by NF induced synthesis of functionally analogous factor in L cells. The results obtained indicate the existence of non-cytotoxic mechanisms of tumour growth immunological control. The isolated lymphokine possessed also the activity of early embryonal cell differentiation factor. It is suggested that lymphokines with the activity of NF are physiological regulators of nonlymphoid cell differentiation.

Animals↗