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Biomedical subjects

A N Cherniaev

Publications and source records attributed to A N Cherniaev.

5 recordsLinked to original sources
PubMedDate not supplied

[Reactions of granulation tissue fibroblasts in regenerating skin to chronic hypoxia].

An investigation of the effect of chronic hypoxia on fibroblasts of the granulation tissue of a regenerating wound showed that an appreciable portion of fibroblasts degenerated and died. Some of the cells retained their capability to synthesize collagen but its excretion outside the cell was disordered. It also demonstrated an inhibition of fibrillogenesis and thus delayed regeneration of an experimental lesion.

Animals↗
PubMedDate not supplied

[The effect of somatotropin on the healing of skin wounds under hypoxic conditions].

Using cytological, histological, histochemical and histoautoradiographic methods, it was demonstrated that skin recovery in the hypoxic state can be stimulated by somatotropin (STH). STH was shown to stimulate wound healing at every stage: cell migration to the injured area was accelerated, microbial phagocytosis and proliferation of epithelial and connective tissue cells were activated. This led to faster granulation and epithelialization of the wounded surface. The de novo formed epithelium showed a higher activity of succinate dehydrogenase and the granulation tissue - a higher activity of alkaline phosphatase. The hormone treatment reduced destruction of cell elements, newly formed vessels and fibrous structures of the wound which was caused by the hypoxic effect.

Animals↗