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Biomedical subjects

A N Gjorgov

Publications and source records attributed to A N Gjorgov.

15 recordsLinked to original sources
PubMed2000

The epidemiology of lip, oral cavity and pharyngeal cancers in Kuwait 1979-1988.

Of the 10 539 cases of cancer recorded in the Kuwait Cancer Registry in the 10 years 1979-1988, 784 (7.4%) involved the lip, oral cavity or pharynx. Nearly half of these were of the nasopharynx or salivary glands, and the incidence of salivary gland cancer appears to be increasing. The aetiology may be related to poor oral hygiene and tobacco-smoking.

Adolescent↗
PubMed1998

Experimental studies: randomized clinical trials.

There are two major approaches to medical investigations: observational studies and experimental trials. The classical application of the experimental design to studies of human populations is the randomized clinical trial of the efficacy of a new drug or treatment. A further application of the experimental studies is to the testing of hypotheses about the etiology of a disease, already tested and corroborated from various forms of observational studies. Ethical considerations and requirements for consent of the experimental subjects are of primary concern in the clinical trials, and those concerns set the first and final limits for implementing a trial. General moral principles in research with human and animal beings, defined by the "Nuremberg Code," deal with strict criteria for approval, endorsement and evaluation of a clinical trial.

Animals↗
PubMed1998

Breast cancer and barrier contraception: postulated and corroborated potential for prevention.

A case-control study and a number of ecological surveys have been conducted in order to test the hypothesis that a reduced exposure to human semen factors during the reproductive lives is an etiological risk factor in the development of breast cancer in married women. The results of the retrospective study, carried out jointly at two universities in the USA during 1974-1978, corroborate the postulated association between the use of barrier contraception (condom or withdrawal) and the breast cancer development in women. The sequential surveys of the last 20 years provided ecological evidence of the predicted and anticipated natural experiment, the epidemic rise of breast cancer internationally during the decades of 1980s and 1990s, and further corroborated the potential for a primary (non-chemical) prevention of breast cancer in the community.

Breast Neoplasms↗
PubMed1995

Stop the natural experimental trial in breast cancer because of rising incidence: summarizing the evidence.

A survey has been conducted during the past decade (starting in 1980) of reported new cases of women with breast cancer, in order to assess the interim evidence of the natural experiment of the effect of increased use of condoms on the risk of breast cancer in the US. Age-adjusted incidence rates of breast cancer (to the world standard population) per 100,000 population, and trends of changes, in percentages, were used. Prior to the 1980s, breast cancer incidence was in decline in seven out of 13 centres in the country. Following the recommendations to use condoms in 'safer sex' campaigns, increases of breast cancer incidence were recorded during the 1980s, as a reflection of a global phenomenon. Between the 5 year periods of 1978-82 and 1983-87, the population of the nine Surveillance, Epidemiology and End Results programme (SEER) centres (about 10% of the American population), increased by 2.9%, the number of breast cancer cases increased by 25.0%; the average annual breast cancer crude incidence rose by 21.5% (from 100.8 to 122.5 per 100,000). The increase in the average annual number of breast cancer cases during the period 1983-87 (the period of increased condom usage) was 4.5 times greater than that during the preceding period, 1978-82. During the 1980s, breast cancer trends rose significantly in the US among White women (P < 0.00001) and other ethnic groups (P < 0.005). The difference between the expected, 21%, and observed, 79%, probability of adverse effects occurring in the natural experimental trial was statistically significant (P = 0.0001).(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1993

Emerging worldwide trends of breast cancer incidence in the 1970s and 1980s: data from 23 cancer registration centres.

The aim of the study was to estimate the change in breast cancer incidence around the world in the last two decades, to investigate a hypothesized rise (of epidemic proportions) in incidence of the disease, and to assess the potential for its prevention. This was done by examining data from 23 registries worldwide. The anticipated widespread and epidemic proportions of the increases in breast cancer incidence were consistent with the proposed hypothesis. The results are discussed in these terms, and alternative actions for the prevention of the epidemic extent of breast cancer in the community are suggested.

Adolescent↗
PubMed1989

Exercise time relationship to coronary risk factors in Kuwaiti adult males 1985-1986.

Two hundred and sixty-nine apparently healthy Kuwaiti men, aged 20-49, from 800 randomly selected Kuwaiti families, were examined for cardiovascular fitness and risk factors for coronary heart diseases (CHD). The risk factors were examined by exercise stress test on Quinton-2000 ECG monitor and treadmill Q-model 24-26, Bruce protocol, along with Ergo-oxyscreen, by laboratory tests of fasting blood lipid levels, and by interview using a questionnaire. The sample was stratified into three age groups, 20-29, 30-39, and 40-49. For the entire sample, the results showed that a number of the investigated factors were significantly correlated with the duration of treadmill exercise time. Univariate analysis indicated that performance was inversely correlated with age, cholesterol levels, cholesterol:HDL ratio, triglycerides and uric acid, weight, body-build indexes, body density, resting heart rate, blood pressure (BP), personal history of CHD, and smoking habits. Most of the observed significant correlations were particularly pronounced in the younger age groups, 20-39 years. In this group, significant results in the analysis of variance were found between the treadmill performance time and a number of risk factors, including: cholesterol levels, age, cholesterol:HDL ratios, triglycerides, uric acid, heart rate, elevated systolic blood pressure, and obesity.

Adult↗
PubMed1978

Barrier contraceptive practice and male infertility as related factors to breast cancer in married women. Preliminary results.

A case-control study was conducted in order to test the hypothesis that a reduced exposure to human seminal factors in the early reproductive life of women is a risk factor in breast cancer. The relative risk of exposure to the hypothetical semen-factor deficiency is 4.7 times greater for breast-cancer patients than for the controls. The risk of developing breast cancer within the same population in the U.S.A. is estimated as 5 times greater for women who use barrier methods (condom and other) than for women who use non-barrier contraceptive methods (diaphragm and other). The reduction of the incidence of breast cancer by eliminating the barrier contraceptive techniques would be not less than 50% in married women in the population.

Adult↗
PubMedDate not supplied

Barrier contraceptive practice and male infertility as related factors to breast cancer in married women.

A case-control study was conducted in order to test the hypothesis that a reduced exposure to human seminal factors in the early reproductive life of women is a risk factor in breast cancer. The relative risk of exposure to the hypothetical semen-factor deficiency is 4.7 times greater for breast-cancer patients than for the controls. When the contraceptive methods alone are taken into account, the relative risk increases up to 5.3. About 16 percent of the women using barrier methods (condom, and other) and 3.4 percent of women using non-barrier contraceptive methods (diaphragm, pill, IUDs, rhythm, tubal ligation, and other) would develop breast cancer. The risk of developing breast cancer within the same population in the U.S. is 5 times greater in women who use barrier methods than in women who use non-barrier contraceptive methods. The reduction in the incidence of breast cancer by eliminating the barrier contraceptive techniques would be not less than 50 percent in married women in the entire population. The possibility of preventive measures within an adequate family planning program is emphasized.

Adult↗