Biomedical subjects

A N Ivanokov

Publications and source records attributed to A N Ivanokov.

7 recordsLinked to original sources

PubMed1985

[Use of polyamine in the complex treatment of multiple sclerosis].

Free amino acids were studied in the blood plasma of 37 patients with multiple sclerosis with different variants of its course. Hypoaminoacidemia and disaminoacidemia in all the patients justified the conduction of the corrective treatment with the Soviet drug polyamine manufactured from balanced crystalline amino acids. The results of treatment of 21 patients with multiple sclerosis are presented. Normalization of the metabolism of free amino acids correlated with the clinical improvement of the patients's status.

Adult↗

PubMed1984

[Experience in using T-activin in multiple sclerosis patients].

Forty patients with multiple sclerosis of a differing course, duration and severity were treated in this series. T-activin was employed as an immunocorrective agent (AFT-6 fraction). The immunological status was assessed in all patients observed prior to, during and after the treatment. Good clinical response was noted in patients with a secondary progressive course; the effect of a short course of treatment with T-activin on the state of patients with a prolonged progressive course or at the stage of stabilization in the presence of severe organic symptomatology was less prominent. AFT-6 showed a beneficial effect on the immunological status of patients, largely on the T-immunity system. Following the treatment, most patients displayed the normalization of the total lymphocyte count and of the proportional content of T-cells with their activity rising.

Adult↗

PubMed1984

[Spectrum of plasma free amino acids in multiple sclerosis patients].

Study of the amino acid spectrum in the blood plasma of 45 patients with multiple sclerosis (MS) demonstrated marked deaminoacidemia with a tendency toward hypoaminoacidemia in all those studied. Characteristic significant changes in the chromatogram of free amino acids were detected at the stages of rapid and slow disease progression, during disease remissions and at the stage of stabilization. The disclosed disorders of the composition of free amino acids contribute to the better understanding of the disease pathogenesis and may serve as a differential-diagnostic criterion in various forms of the MS course. They also make it possible to outline rational directions in the comprehensive management of MS.

Adolescent↗

PubMed1983

[Functional status of the adrenal cortex in patients with multiple sclerosis].

The spectrum of daily urine C21-corticosteroids was examined in 50 patients by thin-layer chromatography on silica gel. There were 28 men and 22 women aged 16--50 years with a disease standing from 1 to 26 years. Twenty-two healthy persons of the same age formed the control group. Appropriate indices were calculated to have a deeper insight into adrenocortical function. The dependence of gluco- and promineralocorticoid activity and of corticosteroid biosynthesis and metabolism on the disease course and acuity was revealed. The data obtained made it possible to elaborate the most rational treatment tactics in patients with disseminated sclerosis and to define the opportunities of glucocorticoid use taking into consideration the adrenocortical response to the pathological process.

17-Hydroxycorticosteroids↗

PubMed1983

[Clinico-electrophysiologic studies of multiple sclerosis patients].

Clinical-electrophysiological examination of 108 patients with demyelinated diseases of the nervous system, which included electromyography, electroneuromyography and study of trunk evoked potentials, allowed the authors to identify criteria of the differential and topical diagnosis in multiple sclerosis, multiple encephalomyelitis and encephalomyelopolyradiculoneuritis. Data provided by a combined electrophysiological examination employing the above listed techniques expand our understanding of individual elements of the pathogenesis of demyelinated diseases involving the nervous system.

Adolescent↗

PubMed1981

[Plasma and erythrocyte free amino acid concentration in patients in the acute period of an ischemic stroke].

Acute disturbances of the cerebral circulation occupy the leading place in the structure of neurovascular diseases. Studies on metabolic processes in the patients, body in the acute period of the stroke and, particularly, the metabolism of free amino acids enable one to expand our knowledge of the pathogenetic essence of the stroke and its differential diagnosis, and thus to decide on the therapeutic measures to be taken for correcting the disturbed metabolism. Of great interest in this connection are dynamic determinations of the levels and the spectrum of free amino acids in biological fluids.

Acute Disease↗

PubMed1979

[Hydroxyproline and acid glycosaminoglycans in acute cerebral circulatory disorders].

In patients with acute disorders of cerebral circulation dynamic examinations of hydroxyproline excretion, total content of glycosamineglycans (GAGs) and content of the latters' fractions were carried out. During the first week of the disease the total content of the GAGs in the urine daily portion was found to be increased, this increase being statistically significant and correlating with the size of the expected brain lesion. The fractional spectrum of the GAGs changed towards greater content of sulphonated fractions. By the 3d--5th week of the disease the hydroxyproline concentration in the urine sharply rose, an evidence of the intense organizational processes within the ischemic focus by that time.

Aged↗