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A N Kudrin

Publications and source records attributed to A N Kudrin.

At least 37 records · Page 2Linked to original sources
PubMed1983

[Alcohol and drugs].

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Alcoholic Intoxication↗
PubMed1982

[Use of the inhibition of myocardial lipid peroxidation for use therapy and prevention of experimental transitory coronary failure].

This work was done on 116 white random-bred male rats using the experimental model of transient coronary insufficiency of varying duration and showed that activation of free-radical peroxidation of myocardial lipids is one of the main pathogenetic factors in the mechanism of development of the ischaemia and reperfusion damage of the heart in transient coronary insufficiency. Inhibition of lipid peroxidation after preliminary administration to the animals of sodium selenite and myophedrine significantly enhanced the heart's resistance to reversible ischaemia. It is suggested that the use of antioxidants is an effective method of pathogenetic therapy and prevention of transient coronary insufficiency.

Animals↗
PubMed1981

[Pathogenetic role of lipid peroxidation and the protective role of sodium selenite in ischemia and myocardial reperfusion].

The data obtained in experiments on 89 random bred male white rats indicate an important pathogenetic role of lipid peroxidation activation during ischemia of the myocardium and its further reperfusion. Inhibition of lipid peroxidation by sodium selenite was accompanied by increased resistance of the heart to its reversible ischemia. The evidence obtained documents a new principle of pathogenetic therapy of transitory coronary insufficiency with lipid peroxidation inhibitors, particularly sodium selenite. The data presented may be of importance for clinical practice since transitory myocardial ischemia in animals represents an experimental model of the forms of coronary heart disease of man which are accompanied by transient reduction of the coronary blood flow.

Animals↗
PubMed1981

[Mechanisms of free radical liquid peroxidation activation during regional ischemia and subsequent reperfusion of the heart].

Experiments on 115 noninbred male rats demonstrated that activation of lipid free-radical peroxidation during transitory coronary insufficiency was observed both in myocardial ischemia and subsequent reperfusion of the heart. The increase in lipid chemiluminescence during the recovery of the coronary blood flow was more pronounced after long-term myocardial ischemia. It was shown that activation of lipid peroxidation during reperfusion was accompanied by the increment of the myocardial content of the peroxidants--adrenaline, oxygen and calcium ions. It is suggested that activation of lipid free-radical peroxidation may be one of the principal factors responsible for the increased myocardial alteration during reversible ischemia, as well as during temporary failure of the coronary blood flow seen in the coronary heart disease of man.

Animals↗