Inducible type of erythromycin resistance among group B streptococci isolated in Greece.
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Anti-Bacterial Agents↗
Biomedical subjects
A N Maniatis
Publications and source records attributed to A N Maniatis.
Increasing prevalence of high-level gentamicin resistance among Enterococci isolated in Greece.
High-level gentamicin-resistant enterococci (HLGRE) (MIC >512 microg/ml) were frequently recovered in the AHEPA University Hospital, Thessaloniki, Greece, during a 15-month period (67/158, 42.4%). PCR testing showed that high-level gentamicin resistance was attributable to the presence of the aac(6')-aph(2") gene, while the recently described genes aph (2")-Ic and aph(2")-Id were not detected. High-level gentamicin resistance could be transferred with varying frequency from 41 of 57 Enterococcus faecalis and 5 of 10 Enterococcus faecium isolates. All transconjugants acquired high-level resistance to streptomycin. HLGRE cause therapeutic problems in our region, since none of the clinically available aminoglycosides can be used in severe infections.
Anti-Bacterial Agents↗
Changing patterns of bacterial nosocomial infections: a nine-year study in a general hospital.
Surveillance data on 12,944 bacterial isolates derived from nosocomial infections, reported to the Department of Microbiology and Infectious Diseases of the Hellenic Air Force and VA General Hospital over a 9-year period (1986-1994), were analyzed by the use of a microbial infection control software system. Overall, the isolation rate of Escherichia coli decreased from 25.2% in 1986 to 18.2% in 1994 and Proteus spp. from 5.3 to 2.6%. Remarkably, Pseudomonas spp. increased from 7.2 to 11.3%, Enterobacter spp. from 1.6 to 5.1%, Klebsiella spp. from 5.9 to 7.8% and Enterococcus spp. from 3 to 7.4%. Interestingly, the above phenomenon was paralleled by a significant increase in resistance rate to various antibiotics. Specifically, Staphylococcus aureus and coagulase-negative staphylococci, though they did not display any significant variation in isolation rates, showed an alarming increase in resistance rate to oxacillin, from 11 and 21% in 1986 to 51 and 75% in 1994, respectively. Enterococcus spp. sensitivity to vancomycin remained unlatered at 90%. The above-mentioned serious shift towards more resistant bacteria should be a matter of consideration.
Bacteremia↗