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Biomedical subjects

A N Oborin

Publications and source records attributed to A N Oborin.

At least 19 recordsLinked to original sources
PubMed1997

[Transfusional action of a new hyperosmotic solution "sorbilact" in the therapy of late experimental hemorrhagic shock].

In experiments on dogs, in whom a severe hemorrhagic shock was simulated the central cardiodynamics functions have been restored, the metabolic acidosis eliminated thrombocytic link of homeostasis normalized, the animals life span increased significantly under the influence of sorbilact intravenous infusion in the dose 10 ml/kg. Probable mechanisms of sorbilact therapeutic effect are considered.

Animals↗
PubMed1994

[Effects of intravenous transfusion of lactosorbal on the course and outcome of experimental hemorrhagic shock].

Severe hemorrhagic shock was simulated in experiment on 5 dogs. The intravenous transfusion of a complex action hemocorrector Lactosorbal in the dose of 10 ml/kg provided the cardio- and haemodynamics indexes restoration, carbohydrate metabolism and acid-base equilibrium normalization, what promoted an experimental animals survival. Possible mechanisms of therapeutic action of preparation were considered.

Animals↗
PubMed1992

[The correction of functional disorders of the hemostatic system and of the rheological properties of the blood in dogs in the late period of hemorrhagic shock by the intravenous transfusion of lactoprotein].

In 9 dogs with severe hemorrhagic shock, the effect of hemocorrector "Lactoprotein" on the indices of coagulative hemostasis and rheologic blood properties was studied. It was established that in intravenous transfusion of lactoprotein at a dose of 10 ml/kg permitting to lead the animals out from the state of shock, the syndromes of disseminated intravascular coagulation and high viscosity of the blood were cupped off. However, by the end of 48 hours of observation, fibrinogen level in the blood of the animals increased sharply, while antithrombin-III concentration and hematocrit decreased. Together with recommendation to use lactoprotein in the complex of shock therapy at all the stages of medical evacuation, the conclusion about necessity to perform at the early postshock period the differential component hemo- and anticoagulative therapy has been made.

Albumins↗
PubMed1992

[Contents of prostaglandins F2alpha, I2 (prostacyclin) and thromboxane A2 in the dog liver during development of hemorrhagic shock].

Contents of prostaglandins (PGs) F2 alpha, I2 and thromboxane (TH) A2 in the liver of 6 dogs has been studied in dynamics of hemorrhagic shock development. The results show that acute haemorrhage (31.9 +/- 1.6 ml/kg) stimulates the synthesis and release of all the eicosanoids studied. Nevertheless, in the progression of shock a significant difference was noticed between the high TXA2 and PGF2 alpha rates and comparatively lower rise of PGI2 production. The late stage of shock (201 +/- 44 minutes after haemorrhage) was characterized by a further rise in TXA2 and PGF2 alpha rates with simultaneous lowering of PGI2 as a result of vascular endothelium affection which is the main source for prostacyclin synthesis. In view of the antagonism of PGI2 to TXA2 and PGF2 alpha and its cytoprotective effects, the results of present investigation give the experimental background for using prostacyclin or its synthetic analogues in a complex therapy of acute liver failure in clinic.

Animals↗
PubMed1991

[Leukotrienes and shock].

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4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyraz↗
PubMed1986

[Effect of the intra-aortic administration of prostaglandin E2 on kidney functions in acute kidney failure of blood transfusion origin].

It has been shown that intraaortal prostaglandin E2 injection to dogs arrested acute renal failure of hemotransfusion genesis, which was expressed in normalization of minute and diurnal diuresis, glomerular filtration rate, tubular reabsorption, maximal tubular secretion, renal plasma flow, urea and creatinine levels. The data obtained serve as an experimental basis for prostaglandin E2 application in the treatment of acute renal failure.

Acute Kidney Injury↗