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A N Oleĭnik

Publications and source records attributed to A N Oleĭnik.

At least 19 recordsLinked to original sources
PubMed2006

[Adenosine deaminase in the complex diagnosis of different forms of extrapulmonary tuberculosis].

The paper summarizes the results of studies of the activity of adenosine deaminase (ADA) in biological fluids (including that during tuberculin tests) as a tool for the differential diagnosis of different forms of extrapulmonary tuberculosis, such as pleuritis, synovitis, meningitis, tuberculosis of female genitals and peripheral lymph nodes, and uveitis. The threshold for the activity of ADA or the magnitude of its increase in antigenic stimulation, which provides the optimum ratio of the sensitivity to specificity of the tests and their maximum diagnostic efficiency, are given. The optimization of diagnosis of tuberculous synovitis is shown to facilitate the study of ADA activity concomitantly with the determination of the level of antituberculosis antibodies. The tests under discussion are economically sound and yield results in several hours and, in case of a provocative test, in 3 days.

Adenosine Deaminase↗
PubMed2003

[Comparative analysis of a new modification of segmental tuberculin test with the routine Koch test].

A focal reaction plays the leading role in the assessment of segmental tests (ST). The sensitivity of ST is 72.4% and that of the Koch test is 64.5%, their specificity is 94.1 and 80.0%, respectively. A 10% or more increase in adenosine deaminase during peritoneal fluid ST indicates to the exacerbation of genital tuberculosis. Analysis of the cellular composition of peritoneal fluid from the Douglas space is proposed as a criterion for a focal reaction. There are ultrasound symptoms which accompany the exacerbation of an inflammatory process in the genitals in response to ST and which are indicative of a positive focal reaction. The minimum tuberculin load and lack of contraindications allow ST to be introduced into the practical work of tuberculosis facilities.

Adenosine Deaminase↗
PubMed2003

[Active genital tuberculosis with peritoneal involvement in women].

The paper presents the results of a study of clinical and laboratory features in patients with active genital tuberculosis with peritoneal involvement. It has been shown that patients with active genital tuberculosis involving the peritoneum show a more pronounced clinical picture and changes recorded by laboratory studies than those with a restrictive process. A growth of the number of patients with specific peritonitis, an unwarranted increase in the volume of surgical interventions, lack of systemic data on this category of patients under the present condition make it necessary to make further studies of this problem.

Adolescent↗
PubMed2002

[Polymerase chain reaction and ligase chain reaction in the diagnosis of gynecological tuberculosis].

The polymerase chain reaction (PCR) and the ligase chain reaction (LCR) were evaluated and compared on 55 gynecological samples collected from women with active gynecological tuberculosis (Group 1), gynecological diseases other than tuberculosis (Group 2), and active tuberculosis elsewhere in the body without evidence for gynecological tuberculosis (Group 3). Acid fast staining and culture of Mycobacteria appeared to be ineffective in all specimens. The sensitivity of both amplification methods was 94.7% (one of the 19 patients with non-tuberculosis). The LCx method showed a very high inhibition by specimens (64.1% of negative samples versus 16.7% for PCR and LCx could be useful tools in the diagnosis of gynecological tuberculosis.

Adult↗
PubMed2002

[Clinical picture of genital tuberculosis in different forms of its pathogen].

Improvement of bacteriological diagnosis is of great value for the clinical picture of genital tuberculosis. The purpose of the study is to reveal the clinical features of genital tuberculosis in L-forms of Mycobacterium tuberculosis (MBT) versus traditional bacteriological methods and polymerase chain reaction (PCR) test with MBT DNA. A hundred and fourteen patients with verified active genital tuberculosis were examined. They were divided into 3 groups: 1) 36 patients with L-forms of MBT in the endometrial scrapes; 2) 32 with bacteriologically verified GT; 3) 46 with positive PCR test. A control group (Group 4) comprised 120 patients with NGD. Among the patients with L-forms there were prevalent females aged 21-40 years (83.4%). These patients had a history of spontaneous abortions more frequently than patients from other groups, in a third was found to have MBT with their L-variants. Signs of intoxication were observed in 47.2%. Oviductal obliteration and specific changes typical of tuberculosis were revealed on a hysterogram in 63.9%, other forms of prior and current extragenital tuberculosis were detected in a half of cases, traces of prior pulmonary tuberculosis were observed in 15%, 63.9% of the patients with L-forms and in 87% of those with positive PCR test were found to have pathological changes in the endometrium, which is indirectly indicative of its lesion. Thus, detection of L-forms of MBT in the endometrial scrapes leads to the conclusion that this is an active sluggish hematogenic tuberculous process, which is evidenced by a complex clinical and laboratory study.

Adult↗
PubMed2001

[Features of surgery on female genital tuberculosis].

The paper gives the outcomes of treatment in 4983 patients treated at the Gynecology Clinic of the Saint Petersburg Research Institute of Phthisiopulmonology in 1977 to 1999. Surgical interventions different in their scope were made in 949 (19%) females. Analyzing 526 females of them indicated that organ-saving operations were performed in most cases (80.2%). Indications for surgery and the time of preoperative etiotropic therapy were defined. Emphasis is laid on that the introduction of laparoscopy into practical phthiosiologic gynecology will solve many problems associated not only with a surgical appliance, but also with the diagnosis of genital tuberculosis.

Female↗
PubMed1998

[Diagnostic values of polymerase chain reaction test in females with genital tuberculosis].

The previously offered procedure for detecting. Mycobacterium tuberculosis, which is based on the polymerase chain reaction (PCR), has been tested for diagnosing genital tuberculosis in females. PCR was used to examine endometrial curettage specimens in 44 patients with different nosological entities, which showed a high sensitivity (80%) and a high specificity in the diagnosis of genital tuberculosis.

DNA, Bacterial↗
PubMed1995

[Clinical aspects of genital tuberculosis in young women].

The review of 108 case histories of active genital tuberculosis (GT) in young women provided the following information: the symptoms emerged acutely in 30%, GT ran under the mask of nonspecific salpingo-oophoritis in 44%, GT was associated with pain, general toxicity, blood picture changes in 50, 30 and 66% of patients, respectively. In 70.7% of young women tuberculosis affected uterine tubes only, whereas in women over 30 years old the infection more frequently occurred in the uterus. 63% of GT females were treated surgically.

Acute Disease↗
PubMed1989

[Peritoneosorption in the treatment of diffuse peritonitis in children].

The article deals with the results of experimental study on 225 inbred albino rats and experience in the treatment of 143 children with terminal and toxic phases of diffuse peritonitis by correction of the pH of the abdominal cavity medium with standard trisamine solution with one-stage and prolonged peritoneosorption by hemodes under conditions of closed and open management of the abdominal cavity.

Animals↗
PubMed1985

[Effect of ethyl alcohol on bile production and lipid peroxidation in tetracycline-induced liver lesions].

The experiments with male albino rats showed that in toxic doses tetracycline induced affections of the liver evident from activation of transferases and alkaline phosphatases in the blood serum, inhibition of bile secretion, synthesis and secretion of bile acids and excretion of bilirubin and cholesterol with the bile. Moreover, the content of the products of lipid peroxidation in liver homogenates increased. Acute intoxication with ethyl alcohol also induced hepatic disorders. However, they were less pronounced. The intoxication was accompanied by inhibition of cholopoiesis associated with increasing free radical oxidation of lipids. On combined use of tetracycline and ethyl alcohol no potentiation or summation of their hepatotoxicity was observed.

Alcoholic Intoxication↗
PubMed1983

[Mechanism of the pro-oxidant activity of tetracycline].

It was shown on male rats that like ethanol tetracycline increased lipid peroxidation (LPO) in the hepatocyte membranes, evident from increased levels of diene conjugates and malone dialdehyde in the liver homogenates, especially on their combination. The signal amplitude of the EPR-forms of cytochrome P-450 and Cu-, Mo- and Fe-containing proteins did not change, while the content of the EPR-forms of the free radicals increased. High efficiency of antioxidants, such as tocopherol acetate, sodium selenite and tincture of Astragalus L. is indirect evidence of the role of the free radicals in initiation of LPO in tetracycline affections of the liver.

Animals↗
PubMed1983

[Alcohol and drugs].

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Alcoholic Intoxication↗