Biomedical subjects

A N Posma

Publications and source records attributed to A N Posma.

7 recordsLinked to original sources

PubMed2005

[Skin cancer and other skin disorders in patients following solid organ transplantation].

Solid organ transplant patients have an increased risk of cutaneous squamous cell carcinomas compared to the immunocompetent population, and often develop multiple and sometimes aggressive tumours. There are few published studies or reviews, which provide guidance to the clinician in the management of these patients. In the prevention of skin cancer in organ transplant patients, patient education about the harmful effects of ultraviolet radiation, sun protection, and the early recognition of (pre)malignant skin lesions should be emphasised. Furthermore, close follow-up by a dermatologist and treatment of (pre)malignant lesions in an early stage are necessary. Chemoprevention of skin cancer can be achieved through systemic retinoids. Reduction of the dose of immunosuppressive agents can be considered. Excision is the first treatment of choice for squamous cell and basal cell carcinomas. In selected rumours curettage and electrodessication can be performed.

Basal Cell Carcinoma↗

PubMed2003

Diffuse neurofibroma on the lower back.

Diffuse neurofibroma is an uncommon form of neurofibroma, which occurs principally in children and young adults. This tumor presents most often in the head and neck region. We have seen a young girl with a diffuse neurofibroma on the lower back that was successfully excised.

Back↗

PubMed2000

Basal cell carcinoma on the dorsum of the hand: report of 11 cases.

BACKGROUND: Basal cell carcinoma (BCC) is the most common cutaneous malignancy, although the appearance on the dorsum of the hand appears to be rare. OBJECTIVES: The purpose of this study was to identify and describe patients with BCC of the dorsum of the hand in a large cohort of BCC patients and to provide a review of the literature. METHODS: Eleven patients with a BCC on the dorsum of the hand were identified. Information on age at diagnosis, sex, treatment and follow up, presence of additional malignancies, etc., was gathered from medical records. RESULTS: Between January 1985 and December 1995, 2990 BCCs were registered, of which 11 were located on the dorsal aspect of the hand (0.37%). Nine patients were male and most patients had a history of multiple skin malignancies. Most of the BCCs were nodular or had a nodular component. Solar elastosis was frequently seen. The percentage of 0.37% compares well with BCC located on the dorsum of the hand in other studies, but also with other parts of the body per skin surface area (except the face and neck area). CONCLUSIONS: The density of BCC on the dorsum of the hand is much lower than in the face and neck area but compares well with other parts of the body.

Adult↗

PubMed1997

The cutaneous innervation of the female breast and nipple-areola complex: implications for surgery.

Many surgical procedures performed in the thoracic region can easily damage cutaneous nerves important for the sensory innervation of the female breast. A better understanding of the distribution of these cutaneous nerves will help prevent impaired sensation after breast surgery. Therefore an anatomical study was performed on the cutaneous innervation of 12 breasts of 7 female cadavers. Special emphasis was placed on the nipple-areola complex. The origin, course and final destination of each cutaneous nerve was established and the contribution of each branch was determined by the area it innervated. Differences were evaluated using analysis of variance. The cutaneous innervation of the female breast is derived medially from the anterior cutaneous branches of the Ist-VIth intercostal nerves and laterally from the lateral cutaneous branches of the IInd-VIIth intercostal nerves. The nipple-areola complex is consistently supplied by the anterior and lateral cutaneous branches of the IVth intercostal nerve, with additional innervation by cutaneous branches of the IIIrd and Vth intercostal nerves. This study shows an equal importance of both the anterior and the lateral cutaneous branches of the intercostal nerves. During surgical procedures one should try to avoid damage to the anterior and lateral cutaneous branches of the IIIrd, IVth and Vth intercostal nerves, with special attention to the IVth intercostal nerve which is the consistent nerve to the nipple-areola complex.

Aged↗

PubMed1995

Treatment of recurrent squamous cell carcinoma of the hand in immunosuppressed patients.

Since 1981, 14 patients with kidney transplants have been treated for recurrent squamous cell carcinoma of the skin of the dorsum of the hand by total skin resection. Frozen sections of the base of the tumor sites were carried out and the denuded area was resurfaced with split-skin grafts harvested from non-sun-exposed areas on the buttock and upper thigh. During follow-up examinations, no recurrence was seen in the grafted areas. The appearance was good and hand function was satisfactory.

Adult↗

PubMed1994

Resurfacing the back of the hand as treatment and prevention of multiple skin cancers in kidney transplant recipients.

BACKGROUND: Skin cancer is a serious problem in renal transplant recipients. In some patients numerous skin cancers develop on the back of the hand. Instead of repeated excisions, a more radical procedure may be necessary. For these patients a new surgical therapy is available: resurfacing the back of the hand. OBJECTIVE: Our purpose was to clinically evaluate this new procedure. METHODS: Eleven kidney transplant recipients who underwent resurfacing of the back of the hand were analyzed in a retrospective follow-up study. With this surgical procedure the skin of the entire dorsum of the hand is excised and split-skin grafts harvested from thigh and buttock skin are then placed. Information was gathered from the medical records and questionnaires, and by physical examination. RESULTS: The mean follow-up time was 4.7 years. No recurrences of skin cancer were observed in the transplanted skin. The cosmetic appearance was acceptable, and there were few side effects. CONCLUSION: Resurfacing the back of the hand can be a successful treatment for carefully selected patients with multiple skin cancers on the back of the hand and can be used prophylactically in patients with severely actinically damaged skin.

Adult↗

PubMed1988

The innervated tensor fasciae latae flap in patients with meningomyelocele.

An anatomical study concerning the sensory innervation of the tensor fascia lata (TFL) area was performed in 51 cadavers. Consequently, an innervated TFL flap was developed with an extended anteromedial border, by comparison with the classic TFL flap. This flap was used in surgery on 6 patients with meningomyelocele at L3 or lower level for unilateral ischial pressure sores. During follow-up, no recurrences were seen either on the operated side or on the contralateral side.

Fascia Lata↗