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Biomedical subjects

A N Shishkin

Publications and source records attributed to A N Shishkin.

At least 19 recordsLinked to original sources
PubMed1996

[The role of immediate-type allergic reactions in the pathogenesis of the nephrotic syndrome].

The study was made of 52 patients with various morphological forms of glomerulonephritis and history of allergy versus 22 healthy subjects. Mean age of the patients was 28.5 +/- 7.2 years. High IgE levels occurred in 37 cases (71.1%). Most of the patients had lipoid nephrosis. Normal levels of IgE were more frequently associated with steroid-resistant nephrotic syndrome characterized by a progressive decline of renal function and severe damage to the glomeruli. A correlation existed between high IgE level and activation of antistreptococcal immunity. Two cases are reported of nephrotic syndrome onset following immediate allergic reaction to food allergen (1 case) and insect sting (1 case).

Adolescent↗
PubMed1994

[The immunogenetic risk factors in the nephrotic syndrome].

An immunogenetic investigation was conducted of 82 patients with renal disease. 48 of them had nephrotic syndrome (NS) of different origin (glomerulonephritis, amyloidosis, diabetic glomerulosclerosis). The findings were compared to those obtained at control population studies of 619 healthy residents of St. Petersburg. A statistically significant increase in the incidence of HLA antigens A-10, B-13, B-35, B-41, DR-2, DR-7 and high homozygosity were found in NS patients. Antigen A-2 occurred statistically less frequently. A relative risk (RR) to develop the disease was in all cases > 2. Typing of NS patients and those with high diagnostic titers of antistreptolysin-O revealed in them a significantly higher occurrence (r < 0.01) of A-10 and B-40 antigens compared to controls and NS-free patients. HLA antigens appeared related to morphological variants of glomerulonephritis running with NS. The study results suggest association between genetic, etiological factors and body's response to injury. Feasibility of NS prognosis is reviewed.

Adolescent↗
PubMed1992

[The clinico-laboratory dynamics in the reaferon treatment of glomerulonephritis patients with the nephrotic syndrome].

Overall 40 chronic glomerulonephritis patients with nephrotic syndrome were treated by reaferon. All the patients underwent clinical and laboratory examinations and nephric biopsy. As a result of the treatment, all the patients demonstrated an increase of the level of glomerular filtration, stabilization of protein and lipid metabolism along with the lowering of diurnal proteinuria. Reaferon exerted a beneficial effect on cellular factors of immunity. In some cases, the use of reaferon can be a definite alternative of the conventional treatment methods.

Adolescent↗
PubMed1992

[Lipidemia in the nephrotic syndrome and the atherogenicity of the plasma].

The nephrotic syndrome is characterized by proteinuria, hypoalbuminemia and hypercholesterolemia. Hypercholesterolemia is in some cases a risk factor for atherosclerosis in this group of patients. The lipid plasma spectrum was studied in 45 patients with the nephrotic syndrome. Most pronounced changes of the lipid composition of the plasma were revealed in patients with systemic lupus erythematosus and a special form of mesangio-proliferative glomerulonephritis which is characterized by a torpid course and rapid development of chronic renal failure. Plasma atherogenicity was calculated according to the index of plasma atherogenicity. A high atherogenicity index was revealed in patients with an association of the nephrotic syndrome and arterial hypertension. Plasma atherogenicity is determined mainly by the level of high-density-lipoprotein cholesterol.

Adult↗
PubMed1992

[Anti-infectious immunity and bacteriuria in patients with the nephrotic syndrome].

The study was made of antiviral antibodies to respiratory viruses, mycoplasma, O-streptolysin, of qualitative and quantitative characteristics of bacteriuria in 52 patients with nephrotic syndrome (NS) due to glomerulonephritis against 18 NS control subjects without glomerulonephritis. Significant differences between the groups appeared in the titers of antibodies to Coxsackie and influenza A viruses. O-streptolysin. Persistence of viral latent infection in NS is suggested as well as a trigger role of viruses in the disease onset and that of other urinary inflammatory affections whose incidence is now on the increase.

Adolescent↗
PubMed1990

[Serodiagnosis of patients with glomerulonephritis].

A comprehensive clinical and morphologic examination of 160 nephrologic inpatients included titration of antibodies to respiratory viruses and to HBsAg and of streptolysin O. A correlation was detected between immunity status parameters and the presence and severity of proteinuria in the patients with chronic glomerulonephritis. Besides routine clinical and laboratory examinations, thorough serologic and virologic studies are necessary for this patient population, for such studies will help determine the trigger mechanism of the disease and thus predict the possible development of the condition.

Antibodies, Bacterial↗
PubMed1990

[Clinical, immunological and morphological evaluation of nephrotic syndrome].

The results are available of combined examination of the kidneys in 84 patients with manifest nephrotic syndrome varying in etiology: 57 had glomerulonephritis, 18 amyloidosis, 9 diabetic nephropathy. The study covered lipid metabolism, immunological status, lifetime morphological investigation of the kidneys. The latter procedure proved advantageous over biochemical and immunological studies in deciding upon nosological diagnosis of nephrotic syndrome and its prognosis. Destruction of podocytic miner processes revealed in all the syndrome cases can serve a uniform morphological substrate underlying massive proteinuria.

Adult↗
PubMed1990

[The role of the kidney lymphatic capillaries in the pathogenesis of the nephrotic syndrome].

As many as 16 patients with nephrotic syndrome (NS) of varying etiology and 10 patients without the NS were examined for ultrastructure of lymph capillaries of the kidney. Many-staged changes, from regenerative to destructive ones, associated with proteinuria growth and formation of the NS were revealed in lymph capillaries of the kidney. Patients with the NS of long standing manifested irreversible destructive processes--destruction of the capillary walls, karyopyknosis and cytoplasm coagulation. Microcirculatory disorders may be regarded as one of the mechanisms implicated in nephropathy progress.

Biopsy↗
PubMed1989

[The nephrotic syndrome in elderly patients].

The most frequent cause of development of the nephrotic syndrome in the elderly is secondary amyloidosis of the kidneys (71%). Most patients showed an association of the nephrotic syndrome with arterial hypertension (74%) and renal failure (59%). As compared with a control group of patients under 40, the elderly revealed concomitant diseases, greater severity and frequency of vascular and interstitial changes during morphological examination.

Adult↗
PubMed1989

[Nephropathies with HBsAg deposition in the kidneys].

Among the 646 kidney biopsies HBsAg deposition in the kidney was found in 14 cases. The clinical course of nephropathy was determined by the morphological variant of the affection. No parallelism was found between HBsAg discovery in the blood and kidney biopsy specimens. HBsAg can be a risk factor for nephropathy development.

Adolescent↗
PubMed1989

[The ultrastructure of the lymphatic capillaries of the human kidneys with various lesions].

Puncture biopsy of the kidneys was carried out in 15 patients with different renal lesions. General clinical, laboratory, light microscopy and electron microscopy of the biopsy specimens were employed. Electron microscopy revealed varying changes in the endotheliocytes of the lymphatic capillaries (increased functional activity, destruction of the lymphatic capillary wall). The diagnostic and prognostic value of the findings is discussed.

Adolescent↗
PubMed1988

[Nephrotic syndrome in mesangioproliferative glomerulonephritis].

Some features of the nephrotic syndrome (NS) were studied in 38 patients with mesangial proliferative glomerylonephritis (MSPGN). Clinicomorphological correlations were deduced, 10-year survival rates were determined. NS in MSPGN can be observed both in diffuse and focal variants, results in clinicomorphological remissions and is not attended by renal functional disorders in most of the patients. The best therapeutic results were achieved with glucocorticosteroids. The 10-year survival rate was 88%. It is assumed that NS main morphological substrate in MSPGN is, first of all, podocytic small outgrowths destruction.

Adolescent↗
PubMed1987

[Repeated intravital morphological studies of the kidneys in patients with glomerulonephritis].

A clinicomorphological study was conducted over time in 62 patients with different morphological types of glomerulonephritis. An increase in vascular, interstitial and sclerotic changes was noted morphologically in most patients, the worst dynamics was observed in membranoproliferative glomerulonephritis. Disease progression was associated with 2 processes; sclerosis of all elements of the renal tissue or active inflammation.

Adolescent↗