PubMed Health⌕ Search

Biomedical subjects

A N Strizhakov

Publications and source records attributed to A N Strizhakov.

At least 19 recordsLinked to original sources
PubMed2006

[The pathogenesis, early diagnosis, and pharmacocorrection of fetal condition disturbances in high risk pregnancy].

A longitudinal retrospective study of 803 women and a prospective study of 739 women were carried out. A complex system of the examination of women with a high placental insufficiency risk, starting from the first trimester, was developed; the appropriateness of the application of new technologies of placental system and fetal examination were substantiated. The authors offer optimal regimens of pharmacocorrection of fetal condition disturbances and the activation of compensatory and adaptive reactions of the fetoplacental complex in placental insufficiency of various origins. The optimal obstetric tactics, the possibilities of therapy and pregnancy prolongation, and indications to operative delivery were defined on the basis of the features of placental dysfunction pathogenesis and a thorough analysis of the features of placental insufficiency in women with a high risk of perinatal complications.

Adolescent↗
PubMed2004

[Clinical significance of examinations of hemodynamics of mother and fetus in physiological and complicated pregnancy].

Summarized in the paper is the experience of defining the clinical significance of examination of hemodynamics of mother and fetus in physiological and complicated pregnancy. The normative parameters of blood circulation in the vessels of mother and their central hemodynamics are described. An interrelation between the changes of central hemodynamics of mother and fetus are shown in the development of gestosis and placental insufficiency. The orientation, succession and changes of blood circulation in the arteries and venous vessels of fetus are demonstrated in chromosomal anomalies, congenital malformation, premature pregnancy, gestosis, fetoplacental insufficiency and postmaturity. It was proven as prognostically valuable to study the parameters of blood circulation of mother and fetus not only in diagnostically complicated pregnancy but also in evaluating the therapy efficiency, as well as in choosing a method and time for delivery and in prognosticating a perinatal outcome.

Female↗
PubMed2001

[Impaired maternal and fetal hemodynamics in the pathogenesis of gestosis].

The study was undertaken to examine the specific features of maternal and fetal hemodynamics in the pathogenesis of gestosis and to develop differential approaches to obstetric policy. For this, a total of 345 pregnant women at risk for gestosis were examined. This condition was prevented using aspirin and trental in 60 women. The findings suggest that hypokinetic central hemodynamics with increased total peripheral vascular resistance and with impaired blood flow in the uterine and spiral arteries are a valid predictor of gestosis. Changes in maternal hemodynamics are revealed just in the late first to early second trimester of gestation. The use of aspirin and trental in patients with hypokinetic central hemodynamics and impaired blood flow in the uterine and spiral arteries reduced the incidence of gestosis by 2.5 times, delayed intrauterine fetal development by 3 times.

Adolescent↗
PubMed1999

[Pathogenesis of systemic hemodynamic disorders and choice of optimal obstetrical strategy in pregnant patients with gestosis].

A total of 810 pregnant women were examined in order to elucidate the pathogenesis of hemodynamic disorders in gestosis. The main group consisted of 460 patients with gestosis of different severity and the control group included 150 women with uneventful pregnancy. Central and regional hemodynamics in normal pregnancy were studied in detail by modern diagnostic methods (echocardiography and dopplerometry) and the relationship between the detected shifts and the function of the utero-placento-fetal circulation was shown. The predominant type of central hemodynamics in gestosis is the hypokinetic. Disorders in renal and cerebral circulation contribute to the pathogenesis of severe gestosis. Pathogenetic variants of hemodynamics shifts in gestosis are analyzed and recommendations on the follow-up of pregnancy are offered. Indications for preterm delivery in the interests of the mother and fetus are defined.

Adult↗
PubMed1996

[Central and regional hemodynamics during the physiological course of pregnancy and the systemic circulatory disorders in gestoses].

Ninety-one patients with physiological pregnancy and gestosis were studied. This included examinations of maternal central hemodynamics and Doppler study of blood flow in the system of carotids, renal artery and its branches, uterine and umbilical arteries. The volumetric maternal central hemodynamic parameters were found to increase concurrently with a reduction in peripheral vascular resistance during physiological pregnancy, which is associated with the emergence and development of a fetoplacental complex. In gestosis, there are decreases in the volumetric maternal central hemodynamic parameters and increases in peripheral vascular resistance in all the vessels under study. Clear diagnostic criteria for predicting and diagnosing gestotic complications, such as preeclampsia and eclampsia, and fetoplacental failure in time have been defined. A contribution of echocardiographic and Doppler studies is shown in the evaluation of the severity of gestosis and the efficiency of the therapy used.

Adult↗
PubMed1995

[The clinical importance of the dopplerometric study of the blood flow in the normal iliac, uterine and ovarian arteries, in myoma and in endometriosis interna of the corpus uteri].

Dopplerometric investigation of pelvic arteries was carried out in 30 women without gynecologic diseases, in 51 patients with internal endometriosis, and 48 ones with uterine myomas. Internal endometriosis of the uterus was found to be characterized by specific qualitative changes in spectral curves of bloodstream velocity in the internal iliac and uterine arteries. Moreover, progressive changes in spectral curves related to dissemination of endometrioid heterotopias were revealed. In patients with uterine myomas combined with internal endometriosis disorders of peripheral circulation typical of endometriosis predominated.

Adult↗
PubMed1995

[The interferon inducer neovir (kamedon) in the combined treatment of chronic inflammatory diseases of the adnexa uteri of chlamydial etiology (a clinical electron-microscopic study)].

One of the major factors of nonspecific immunity i.e. the state of the host interferon system was studied with a purpose of its correction in the treatment of inflammatory diseases of the uterine appendages of the chlamydial etiology. In all the female patients with chronic inflammatory diseases of the uterine appendages of the chlamydial etiology there was observed a disorder in the function of the interferon system link: a decrease in the concentration of blood serum interferon and a lower capacity of the blood cells to produce alpha- and gamma-interferons. The findings were used as a theoretical ground for the inclusion of neovir, an inductor of alpha-interferon to the treatment of such patients. After the completion of the treatment course with the use of neovir the index of the serum interferon proved to be higher than the normal by 2.4 log2IU and the indices of alpha- and gamma-interferons were lower than the normal only by 0.1 and 1.3 log2IU respectively. Therefore, the mechanism of the neovir action included activation of the function of the interferon endogenic system. The morphometrical analysis of the number of the cytoplasmic granules of the polymorphonuclear leukocytes in the peripheral blood before, during and after the therapy with neovir and pefloxacin showed that neovir not only promoted restoration of the digestion function of the neutrophilic leukocytes but also markedly activated it which provided a success of the phagocytic attack.

Acridines↗
PubMed1995

[Myometrectomy--a method of choice for the therapy of adenomyosis patients in the reproductive period].

Seventy-six patients with adenomyosis were examined using computer-aided hysterosalpingography and transvaginal ultrasonic scanning in the "pseudocolor" mode. Organ-sparing operation, myometrectomy (removal of the involved myometrium with preservation of the uterus) was performed in 8 patients aged 18 to 34. In the postoperative period, conservative therapy was administered. Fifty percent of patients became pregnant within a year after the operation.

Adolescent↗
PubMed1994

[Current concepts in observation and treatment of patients with internal endometriosis of the uterus].

The paper outlines the issues of improving and systematizing clinical instrumental diagnostic and therapeutical techniques for internal endometriosis. The results of examining 220 patients with internal endometriosis, out of whom 116 were further operated on, have been prospectively and retrospectively studies. Based on the histological findings of the gross specimens intraoperatively removed, the authors analyzed the predictive value of clinical and instrumental diagnostic criteria, including those of transvaginal echography, Doppler echometry of the arteries supplying the uterus, those of hysteroscopy and the computer hysterosalping graphic technique developed by them. The ovarian morphological and receptor apparatuses were studied in internal endometriosis. The examination and treatment system for patients with internal endometriosis is presented in the paper.

Adolescent↗
PubMed1994

[Role of immune disorders in the pathogenesis of suppurative inflammatory diseases of the adnexa uteri].

Clinical and immunological studies were carried out in 60 patients with tubal pyoinflammatory diseases and in 20 healthy controls of a reproductive age. The immunity status was studied using IKO monoclonal antibodies to differentiation antigens of peripheral blood mononuclears. An acute purulent process was found to be characterized by an adaptive increase in the count of mononuclears carrying the markers of B lymphocytes (CD22, IgM mu-chain), of activated cells (CD38, HLA-D(r)), and of the total number of positive correlations between immunocompetent cells. A persistent course of tubal inflammation is connected with hyperproduction of antibodies and immune complexes, increased expression of HLA-Dr antigens in combination with congenital or acquired insufficiency of T-helper/inductors and suppressors/cytotoxic T-cells. An important factor in the development of a chronic suppurative process is triggering of immunocomplex mechanisms associated with fixation of IgG, IgM, and the complement in the walls of small vessels in the uterine tubes, with a high level of circulating immune complexes, and appearance of plasma cells containing IgG and IgM in the tissues of uterine tubes.

Adolescent↗
PubMed1994

[Endometrial and ovarian morphology in internal uterine endometriosis].

The ovaries and endometrium were examined in 66 patients with internal uterine endometriosis with various degrees of the process dissemination. A high incidence of combinations of uterine endometriosis with hyperplastic processes in the ovaries was revealed (72.7%) and a relatively low incidence of uterine body mucosa involvement (31.7%). The degree of endometriosis dissemination in the myometrium and the incidence of ovarian hyperplasia were in direct proportion. The authors emphasize the usefulness of morphologic studies of the ovaries in patients with internal uterine endometriosis.

Adult↗
PubMed1993

[Uterine-placental-fetal blood flow and fetal cardiac activity during the ginipral treatment of premature labor].

Effects of intravenous and oral hinipral on the uteroplacentofetal blood flow and fetal heart work were studied in tocolytic therapy of preterm labor in 27 pregnant women at terms 25-35 weeks. Intravenous infusions of hinipral resulted in a significant reduction of the systolic-diastolic ratio in the umbilical artery, with the blood flow in the uterine arteries persisting stable, and in a significant reduction of the fetal heart rate and increase of fetal heart rhythm variability, as evidenced by cardiotocogram. In oral tocolysis the reduction of the umbilical artery was related to the pregnancy term; fetal heart rate and heart rhythm variability were within the normal range over the course of the investigation. The results evidence no negative effects of the drug on the uteroplacentofetal blood flow and fetal cardiovascular system both in oral and parenteral forms of tocolysis.

Abortion, Threatened↗
PubMed1993

[The clinico-diagnostic importance of evaluating the blood flow in the mother-placenta-fetus system in EPH gestosis].

A dynamic dopplerometry of the blood flow in the mother-placenta-fetus system, carried out in 79 women with EPH gestosis, revealed a direct correlation between uteroplacental and fetoplacental blood flow disturbances and gestosis, hypertension, edematous syndrome, and proteinuria severity. Comprehensive assessment of the blood flow in both uterine arteries and umbilical artery are preferable. When third-degree circulatory disturbances are revealed in the mother-placenta-fetus system, cesarean section is recommended. Comprehensive dopplerometric assessment of uterine and umbilical arteries blood flow may be regarded as an objective indicator of gestosis severity, whatever its clinical manifestations.

Adult↗
PubMed1992

[Doppler-metric and Doppler echocardiographic study of the nature and stage of disorders of fetal hemodynamics in intrauterine fetal growth retardation].

Pregnancy course, labor outcome, and doppler-metric findings were analyzed in 174 women, 98 with normal pregnancy (controls) and 76 with small-for-date fetuses when examined on weeks 28-41; the aim of the study was to analyze the pattern of hemodynamic disorders in small-for-date fetuses. A classification of fetal hemodynamic disorders has been developed, that distinguishes three types of disorders differing in severity: first degree--disordered fetoplacental circulation not reaching the critical values and satisfactory fetal hemodynamics; second degree--compensated disorders of fetal hemodynamics; third degree--critical state of fetal hemodynamics. Use of this classification in clinical practice will help define rational strategy of pregnancy follow-up.

Echocardiography, Doppler↗