Biomedical subjects
A N WEINBERG
Publications and source records attributed to A N WEINBERG.
Studies on cell lines developed from the tissues of patients with galactosemia.
Cell lines were developed from biopsies on galactosemic and non-galactosemic patients. It was shown that one can discriminate between lines from the two types of donors by their relative growth in glucose and galactose and by their ability to oxidize galactose-1-C(14). The latter method was successful in distinguishing a heterozygous cell line from the normal ones. Sensitivity of galactosemic cells to galactose was suggested by some of the experiments. The kinetics of growth were in some ways reminiscent of a similar phenomenon in the transferase mutants of E. coli, though in the human cells the effect was much less marked.
The effect of high galactose diets on urinary excretion of amino acids in the rat.
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Effects of anterior pituitary hormones on glucose metabolism by rat mammary gland in vitro.
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Detection of congenital galactosemia and the carrier state using galactose C14 and blood cells.
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Effect of galactose-1-phosphate on glucose oxidation by normal and galactosemic leukocytes.
During incubation with galactose, galactosemic leukocytes accumulated more galactose-l-phosphate than did normal leukocytes. Concomitant determination of glucose oxidation, with C(14) glucose, revealed no inhibition of the hexosemonophosphate pathway. These results are at variance with recent studies in rat lens tissue, which suggests that intracellular galactose-1-phosphate depressed glucose-6-phosphate dehydrogenase activity and the oxidative pathway.
The chromosome complement in true hermaphroditism.
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Properties of galactosemic cells in culture.
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