Biomedical subjects

A N Zhou

Publications and source records attributed to A N Zhou.

4 recordsLinked to original sources

PubMed2005

Effects of an acetone extract of Boswellia carterii Birdw. (Burseraceae) gum resin on adjuvant-induced arthritis in lewis rats.

Ruxiang (Gummi olibanum), the dried gum resin of Boswellia carterii (BC), has been used in traditional Chinese medicine to alleviate pain and inflammation for thousands of years. In this random, blinded study, the anti-arthritic effects of a BC extract were observed and compared to vehicle control in a Lewis rat adjuvant arthritis model (n=8/group). Arthritis was induced by injecting CFA subcutaneously into the base of the tail, and the extract was administered orally (i.g.) for 10 consecutive days beginning on day 16 after the injection. Arthritic scores, paw edema, and the local tissue pro-inflammatory cytokines tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1beta) were assessed. Toxicity and adverse effects of the extract were evaluated. At 0.90 g/kg per day, BC significantly decreased arthritic scores between days 20 and 25 (p<0.05) and reduced paw edema on days 18, 20 and 22 compared to control (p<0.05). It also significantly suppressed local tissue TNF-alpha and IL-1beta (p<0.05). No major adverse effects were observed in animals during the repeated-dose treatment profile although mild fur discoloration was noted. The data show that BC extract has significant anti-arthritic and anti-inflammation effects and suggest that these effects may be mediated via the suppression of pro-inflammatory cytokines.

Animals↗

PubMed1999

MMPI changes associated with therapeutic intervention: a migraine control study.

The investigation of personality traits of migraineurs with the Minnesota Multiphasic Personality Inventory (MMPI) is important research, but so far has led to diverse conclusions. This study aimed to investigate the influences of treatment intervention on the personality of migraineurs. Twenty-three Chinese patients (5 men, 18 women) with migraine (2 with aura, 21 without aura) were given the Chinese edition of the MMPI, before and after treatment, and were compared with 30 nonheadache healthy control subjects (6 men, 24 women). Statistical analyses were made among the three groups. The results revealed that patients in the pretreatment group with migraine had significantly higher scores on subtests of neuroticism (hypochondriasis, depression, hysteria) and schizophrenia. After treatment, the scores on subtests of hysteria, psychasthenia, and schizophrenia were remarkably lower (P < .05); the MMPI profile of the posttreatment group was within the reference range, but the scores of the neurotic scales were still higher than those of the healthy control group (P < .01). These results suggest that after treatment, disturbances in thinking, sentiment, and behavior were eliminated, and anxiety symptoms remarkably reduced, but some "migraine personality" characteristics remained and could influence the long-term results of treatment to some extent. It is suggested that management of migraine should include psychological intervention.

Adolescent↗

PubMed1999

MMPI manifestations of Chinese migraine syndromes: a control study.

The investigation of personality traits of patients suffering from migraine headache with the Minnesota Multiphasic Personality Inventory (MMPI) is an important line of research, and differentiating syndromes in treating this disease is one of the characteristics of Chinese Medicine (CM). This study presents the MMPI-(Chinese edition) responses of 80 Chinese subjects with migraine and 40 non-headache healthy control subjects. Among them, migraine fire syndrome (MF) group consisted of 45 subjects (10 men, 35 women); migraine Qi stasis syndrome (MQ) group, 35 subjects (8 men, 27 women). The healthy control group was divided into healthy Qi stasis syndrome (HQ) group, 9 subjects (2 men, 7 women); and healthy normal (HN) group, 31 subjects (7 men, 24 women) according to CM diagnostic criteria. Statistical analysis was performed by pairs among four groups. The results revealed that both MF and MQ groups' MMPI profiles were significantly higher than that of the Normal (HN) group, and formed a 1.2.3.7 type slope. Profile deviation in the MQ group was slight, but in the MF group was serious and accompanied by a significant rising scores in F, paranoia (6), schizophrenia (8) and social introversion (0) subtests; HQ group's MMPI profile had a similar deviation as in the MQ group. The results suggest that CM migraine syndromes have an exact expression on MMPI profile, and that MMPI as an effective diagnostic method could be applied for CM syndrome discrimination. The "deviation of migraineurs' personality" may not be a special characteristic held only by migraineurs. The existence of different syndromes in migraine is one of the reasons that different scholars have reported different results on migraine by means of MMPI.

Adolescent↗

PubMed1995

An MMPI control study: Chinese migraineurs during frequent headache attack intervals.

The investigation of personality traits of migraineurs with the Minnesota Multiphasic Personality Inventory (MMPI) is an important line of research, but so far has led to diverse conclusions. In this study, the MMPI (Chinese edition) responses of 50 Chinese subjects (10 men, 40 women) with migraine (4 migraine with aura, 46 without aura), during frequent headache attacks were compared with 30 nonheadache healthy control subjects (6 men, 24 women). Statistical analysis was made between the two groups. The results revealed that subjects in the migraine group had significantly higher scores on subtests of neurotic, (hypochondriasis, depression, hysteria, and psychasthenia), schizophrenia, and social introversion (P < 0.05 to 0.001). Utilizing the American T-score, we found the migraine group's MMPI profile was a typical 1.2.3.7 model. These results suggest migraineurs with frequent headache attacks have multiphasic personality abnormalities and partial cerebral function disturbances.

Adolescent↗