Biomedical subjects

A N Zosimov

Publications and source records attributed to A N Zosimov.

15 recordsLinked to original sources

PubMed2004

[Diagnostic value of immuno-hormonal relationships in adolescents in early primary tuberculosis infection].

The immunological and hormonal links of homeostasis and the pattern of their relationships were studied in 137 adolescents with early primary tuberculous infection (EPTI) and 79 adolescents uninfected with tuberculosis (control). There was a significant increase in the specific functional activity of T lymphocytes and a reduction in their nonspecific functional activity as compared with the controls, as well as an elevation of the levels of thyroxine, cortisol, and insulin. In EPTI, there was an unbalanced enhancement of the activity of cortisol and insulin with the relative deficiency of the latter, which is indicative of overstrain of nonspecific adaptation reactions. In EPTI, integration of immune-hormonal liaison has been established to occur with the radical (90%) change of the body's functional system. Highly reliable two-dimensional indicators have been proposed for the diagnosis of EPTI in adolescents.

Adolescent↗

PubMed1995

[Immunological and hematological criteria of the prognostication of the effectiveness of tuberculosis chemoprophylaxis in children].

Immunological indices and hemograms were studied in 80 children early in the course of primary tuberculous infection to ascertain prognostic criteria of chemoprophylaxis efficacy. Of prognostic importance appeared: to be the Mantoux test with 2 TU PPD-L; T-lymphocyte, T-helpers, active T-lymphocytes, leukocyte, eosinophil count; leukocyte migration inhibition test with pulmonary antigen and BCG; hemogram assessment according to Garkavi and its dynamic changes 1 month after chemoprophylaxis. Basing on these prognostic criteria relevant algorithms have been derived.

Algorithms↗

PubMed1994

[Specific risk factors of the development of early period of primary tuberculous infection in children].

The role of the tuberculosis contact and specific BCG immunoprophylaxis in the onset of early primary tuberculosis is investigated. Primary infection from tuberculous and healthy families depended on BCG quality, the number of BCG vaccination marks and postvaccination time. Upon the comparison of informative value of specific and nonspecific factors it was found that specific factors are leading in pathogenesis of present-day primary tuberculosis infection.

Adolescent↗

PubMed1993

[The complex assessment of the health status of children in the early period of primary tuberculous infection taking health groups into account].

Children belonging to different health groups aged 4-14 (n = 350) with a turn in tuberculin reactions were examined for a relation of their health status to the onset, course and chemotherapy outcomes of early tuberculous infection. Health groups 3 and 4 appeared risk factors by a turn in tuberculin reactions. An inverse relationship was revealed between children's health and their immune status, whereas general condition of the examinees and efficacy of their chemotherapy correlated directly.

Adolescent↗

PubMed1993

[Correlation of dermatoglyphic and cellular immunity parameters in children with early stage of primary tuberculosis].

Immunological status and dermatoglyphic characteristics were compared in 55 children aged 4-14 with a turn in tuberculin reactions. A correlation was established between genetic and immunological factors, this pointing to the fact that dermatoglyphics is a component of genotype indicative of natural resistance of children to tuberculosis. Synchronization between immunological and genetic values is less intensive in children with immunological disorders against those without them. The findings support the hypophysis on an evolutional role of M. tuberculosis as natural selection factors as well as setting up genetically determined mechanisms of natural resistance to tuberculosis.

Adolescent↗

PubMed1991

[The role of phenotypic factors in predicting the effectiveness of pharmacological prevention of tuberculosis in children].

The role of genetic markers such as dermatoglyphics, sex and INH inactivation in predicting the efficiency of tuberculosis chemoprophylaxis has been studied in 76 children (41 boys and 35 girls) with a tuberculin reaction reversal. The dermatoglyphic signs and the type of INH inactivation were found to be related to the efficiency of chemoprophylaxis. This makes it possible to use the child's phenotype for prognosis and better individual approach to tuberculosis chemoprophylaxis. An association has been found between the INH inactivation type and dermatoglyphics.

Child↗

PubMed1988