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Biomedical subjects

A Németh

Publications and source records attributed to A Németh.

At least 91 records · Page 5Linked to original sources
PubMed1985

Screening of children with high familial risk of arteriosclerosis.

Serum total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), very low density lipoprotein cholesterol (VLDL-C) and total triglyceride levels were determined in children with high risk arteriosclerotic family history. Significantly higher TC and lower HDL-C levels were found in children whose parents' first arteriosclerotic sign had appeared before 40 years of age. There were no similar significant alterations observed in children whose parents' first arteriosclerotic symptom appeared after the forties. Screening therefore seems to be necessary in the offsprings of patients if the first sign of arteriosclerosis has been detected before 40 years of age.

Adolescent↗
PubMed1985

Neonatal pulmonary haemorrhage, birthweight, gestational age and intrauterine growth.

The relation between neonatal pulmonary haemorrhage and its underlying cause was studied by reviewing the clinical data and necropsy records of 315 newborn babies who had died between day 0 and 31 of life. Necropsy revealed massive and focal pulmonary haemorrhage in 6.9% and 19.3% of the infants, respectively. It has been concluded that pulmonary haemorrhage is a complication of various neonatal diseases related to hypoxia and/or infection, which occur in preterm infants with a much higher frequency than in term babies. Among patients with pulmonary haemorrhage, males and low birthweight babies predominated.

Birth Weight↗
PubMed1984

A pancreatic-polypeptide-producing tumor of the stomach.

A gastric tumor was found in a 64-year-old woman who later developed flushing, tachycardia, headache, and lacrymation. The plasma pancreatic polypeptide (PP) level was 700 times normal values, and the majority of the tumor cells were immunoreactive to PP antiserum. Symptoms were alleviated, and PP levels fell after embolization of the hepatic artery for liver metastases. This is the first reported case of gastric PP-producing endocrine tumor.

Apudoma↗
PubMed1984

Urinary excretion of tetrahydroxylated bile acids in children with alpha 1-antitrypsin deficiency and neonatal cholestasis.

Urinary excretion of bile acids was investigated in seven infants with alpha 1-antitrypsin deficiency and neonatal cholestasis. The infants were followed prospectively and the bile acid analysis was repeated after 2-8 years in four of the patients. Bile acid excretion during 24 h was quantified by gas-liquid chromatography and the bile acids were identified by gas-liquid chromatography-mass spectrometry. In contrast to healthy controls, all the patients excreted tetrahydroxylated bile acids during cholestasis and in the postcholestatic period. The patients who developed cirrhosis during the observation period had lower concentration of tetrahydroxylated bile acids than those with a more favourable course. Our findings suggest that tetrahydroxylation of bile acids might be an alternative pathway for elimination of bile acids in cholestasis of infancy, and that those infants exhibiting a good capacity of polyhydroxylation might have a better prognosis.

Bile Acids and Salts↗
PubMed1984

The effect of gastric cytoprotective drugs (atropine, cimetidine, vitamin-A) on the indomethacin induced intestinal ulcers in rats.

The effect of various gastric cytoprotective drugs was studied on the development of indomethacin induced intestinal ulcers. CFY strain rats weighing 200-250 g were used. Indomethacin in a single dose of 20 mg/kg was given intragastrically in 1.5 ml. The animals received atropine (0.025-0.2-1.0 mg/kg), cimetidine (2.5-10-50 mg/kg) or vitamin-A(0.1-1.0-10 mg/kg) intraperitoneally in a single dose 15 min before the administration of indomethacin. In another study the animals received the same doses of atropine twice a day for 3 days. The small intestine was examined for lesions consisting of: (a) palpable nodules on the mesenteric attachement: (b) ulcers in the jejunum and ileum: (c) adhesions as a consequence of ulcer perforation. Neither histamin H2 receptor antagonists, anticholinergics, nor vitamin-A affected the number and the severity of the indomethacin induced intestinal ulcers. These results suggest that, whereas atropine, cimetidine and vitamin-A have a cytoprotecting effect in the stomach, it appears that they have no role in intestinal cytoprotection.

Animals↗
PubMed1983

Alpha-1-antitrypsin deficiency and juvenile liver disease. Ultrastructural observations compared with light microscopy and routine liver tests.

Sixteen children (aged between 1 month and 20 years) with alpha-1-antitrypsin deficiency (PiZ) were investigated by liver biopsy on one or more occasions. Eight patients had suffered from neonatal cholestasis, and two of them were investigated during the cholestatic period as well. The clinical status and liver function tests were compared with the light and electron microscopical findings. According to the light microscopical analyses at the latest investigation, the cholestatic and noncholestatic patients were classified as healthy, fibrotic or cirrhotic cases. All livers displayed periodic acid-Schiff positive, diastase-resistant globules in some but not all periportally located hepatocytes. By electron microscopy accumulation of retained secretory material was found in all PiZ patients. This accumulation was most conspicuous in the smooth endoplasmic reticulum of hepatocytes. alpha-1-antitrypsin deficiency seems to affect some, but not all hepatocytes. In the affected cells disappearance or hypotrophy of the Golgi complex could be observed. The intracellular transport of very low density lipoproteins (VLDL) was apparently not affected. The migration block in alpha-1-antitrypsin deficiency seems to occur before transportation to the Golgi complex. The extent of the involvement was not strictly age-dependent. There was no ultrastructural evidence of subclinical cholestasis as a possible triggering factor in the development of cirrhosis.

Adolescent↗
PubMed1983

Application of the immunoperoxidase technique to formalin fixed, paraffin embedded kidney biopsies.

Different immunohistological methods were compared in 30 renal biopsy cases. The direct immunoperoxidase method gave identical results with immunofluorescence in 88% concerning IgG and C3, while IgA, IgM and fibrinogen have been identically detected by the PAP method in 82%. The non-identical results of the direct method consisted, with one exception, of negative readings, while the non-identical PAP readings were positive with two exceptions. Thus the trypsin-immunoperoxidase method proved to be well applicable on paraffin embedded formalin fixed material. In 10 cases the HRP-labelled direct method was applied also to fresh, frozen sections. It gave almost entirely identical results to immunofluorescence.

Biopsy↗
PubMed1982

The effect of triiodothyronine-prednisolone treatment on the development of digestive enzymes in the suckling pig.

Thirty suckling pigs of 4 litters were divided into an experimental and a control group. The experimental piglets were treated perorally from 14 to 20 days of age with rising doses of triiodothyronine, which were combined with prednisolone for the last 3 days. On the day following the conclusion of the treatment (at 3 weeks of age) the piglets were killed by bleeding for the determination of digestive enzymes. The experimental piglets showed a significant increase of intestinal trypsin (p less than 0.01) and pancreatic amylase (P less than 0.05) activities over the control; a significant decrease of gastric chymosin activity (P less than 0.05) was caused by the great inter-group differences within one litter. Ten of the 11 parameters tested indicated precocious maturation of the digestive enzymes of the experimental piglets, however, most of these differences were not significant. Further studies are required for the possible utilization of this finding in the early weaning practice.

Animal Population Groups↗
PubMed1982

Early membrane retrieval following exocytosis in rat mast cells.

The fate of the surplus membrane following exocytosis of mast cell granules was studied by the extracellular tracer Ruthenium red (Ru red). Isolated rat peritoneal mast cells were stimulated with 4 micrograms/ml polylysine, washed and maintained in a culture medium for 80 min. Mast cells were observed both with the light microscope after adding Ru red in physiological solution and with the electron microscope after fixation in Ru red-containing fixatives. Whereas all exocytotic cavities were found to be stained with Ru red immediately after stimulation, a gradual lack of staining was observed in the subsequent period. The exits of the cavities were sealed by membrane fusions which resulted in closed vacuoles containing exocytosed granule remnants. These vacuoles often fused with each other to form a few giant vacuoles. The overwhelming majority of the vacuoles were observed to be closed 30 to 80 min after stimulation. In one experiment a quantitative analysis was performed to assess the degree of membrane recapture by sealing of the exocytotic cavities. A considerable portion of the plasma membrane area was retrieved in this way as early as between 15 and 30 min after stimulation. We conclude that the dominant mechanism of membrane retrieval in the early period following exocytosis is the recapture of large membrane areas by sealing of exocytotic cavities.

Animals↗