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Biomedical subjects

A Nachtigal

Publications and source records attributed to A Nachtigal.

7 recordsLinked to original sources
PubMed2002

Bone Browser a decision-aid for the radiological diagnosis of bone tumors.

Bone Browser, a decision-aid for radiological diagnosis of bone tumors, was developed in cooperation with the Radiology Department of the Rambam Medical Center, Haifa. The system offers case specific advice from an expert system (ES), general information on the lesion area and allows for recording and retrieving cases. The ES utilizes both rule-based and probabilistic inferencing methodologies to arrive at a differential diagnosis (DD). The knowledge base was validated on 105 cases with known outcome. Clinical evaluation consisted of 59 new cases whose final diagnosis was not known to the evaluators. The correct diagnosis was included in the system's DD in 85% of the cases, which is comparable to the diagnostic accuracy of senior radiologists (88%). The system proved to be helpful to the expert, diagnosing cases missed by the radiologists and suggesting additional diagnoses not listed by the radiologists, raising their diagnostic capability to 91%.

Adolescent↗
PubMed1999

Vertebral involvement in SAPHO syndrome: MRI findings.

We report on the MRI findings in the vertebrae and surrounding soft tissues in two patients with the SAPHO syndrome (Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis). The MRI findings include abnormal bone marrow signal, either focal or diffuse, of the vertebral bodies and posterior elements; hyperintense paravertebral soft tissue swelling and abnormal signal of the intervertebral discs. These changes are consistent with discitis and osteitis.

Acquired Hyperostosis Syndrome↗
PubMed1997

Arthritis as the presenting symptom of diverticulitis.

We describe a patient in whom peripheral arthritis was the presenting symptom of diverticulitis. The joint inflammation resolved only after treatment for the gastrointestinal disease. The pathogenesis, clinical aspects and management of this condition are discussed.

Arthritis↗
PubMed1995

Spontaneous fracture of the sternum simulating myocardial infarction.

Spontaneous fractures of the sternum are rare but worth knowing as they may simulate acute cardiac and pulmonary emergencies. A case of an insufficiency sternal fracture mimicking myocardial infarction and subsequent anginal pain is presented. The risk factors of this condition, its clinical features and the diagnostic procedures are discussed. Spontaneous fractures of the sternum should be considered as a diagnostic possibility for unexplained chest pains in the elderly.

Diagnosis, Differential↗
PubMed1995

Tumor-induced osteomalacia.

Tumor-induced (oncogenic) osteomalacia is a rare clinicopathologic entity in which the clinical signs and symptoms of osteomalacia and the specific laboratory abnormalities of hypophosphatemia, hyperphosphaturia, and low serum levels of 1,25(OH)2 vitamin D are associated with the finding of a neoplastic process in the patient. To date, less than 100 cases of oncogenic osteomalacia have been described. We report a new case of adult-onset hypophosphatemic osteomalacia leading to the discovery of an asymptomatic phosphaturic mesenchymal lung tumor. Complete resection of the pulmonary neoplasia was followed by rapid normalization of the laboratory findings and clinical remission. The clinical, laboratory, and histopathologic spectrum of tumor-induced osteomalacia is presented, and the postulated mechanism of this condition is discussed in light of the relevant literature. The presence of occult neoplasms should be considered in cases of unexplained adult osteomalacia, with the physician's efforts being rewarded by the dramatic cure that follows excision of the tumor.

Adult↗